Sinusoidal obstruction syndrome laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
The diagnosis of sinusoidal obstruction syndrome should be considered in any patient who has undergone hematopoietic cell transplant and develops liver dysfunction. | The diagnosis of sinusoidal obstruction syndrome should be considered in any patient who has undergone [[Hematopoietic stem cell transplantation|hematopoietic stem cell transplant]] and develops [[Liver disease|liver dysfunction]]. | ||
* The following tests can be performed in patients with suspected sinusoidal obstruction syndrome (SOS):<ref name="pmid8420443">{{cite journal |vauthors=McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, Hardin BJ, Shulman HM, Clift RA |title=Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients |journal=Ann. Intern. Med. |volume=118 |issue=4 |pages=255–67 |year=1993 |pmid=8420443 |doi= |url=}}</ref><ref name="pmid7853806">{{cite journal |vauthors=Zager RA |title=Acute renal failure in the setting of bone marrow transplantation |journal=Kidney Int. |volume=46 |issue=5 |pages=1443–58 |year=1994 |pmid=7853806 |doi= |url=}}</ref><ref name="pmid12900777">{{cite journal |vauthors=Hahn T, Rondeau C, Shaukat A, Jupudy V, Miller A, Alam AR, Baer MR, Bambach B, Bernstein Z, Chanan-Khan AA, Czuczman MS, Slack J, Wetzler M, Mookerjee BK, Silva J, McCarthy PL |title=Acute renal failure requiring dialysis after allogeneic blood and marrow transplantation identifies very poor prognosis patients |journal=Bone Marrow Transplant. |volume=32 |issue=4 |pages=405–10 |year=2003 |pmid=12900777 |doi=10.1038/sj.bmt.1704144 |url=}}</ref> | * The following tests can be performed in patients with suspected sinusoidal obstruction syndrome (SOS):<ref name="pmid8420443">{{cite journal |vauthors=McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, Hardin BJ, Shulman HM, Clift RA |title=Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients |journal=Ann. Intern. Med. |volume=118 |issue=4 |pages=255–67 |year=1993 |pmid=8420443 |doi= |url=}}</ref><ref name="pmid7853806">{{cite journal |vauthors=Zager RA |title=Acute renal failure in the setting of bone marrow transplantation |journal=Kidney Int. |volume=46 |issue=5 |pages=1443–58 |year=1994 |pmid=7853806 |doi= |url=}}</ref><ref name="pmid12900777">{{cite journal |vauthors=Hahn T, Rondeau C, Shaukat A, Jupudy V, Miller A, Alam AR, Baer MR, Bambach B, Bernstein Z, Chanan-Khan AA, Czuczman MS, Slack J, Wetzler M, Mookerjee BK, Silva J, McCarthy PL |title=Acute renal failure requiring dialysis after allogeneic blood and marrow transplantation identifies very poor prognosis patients |journal=Bone Marrow Transplant. |volume=32 |issue=4 |pages=405–10 |year=2003 |pmid=12900777 |doi=10.1038/sj.bmt.1704144 |url=}}</ref> | ||
**[[Complete blood count]] | **[[Complete blood count]] | ||
**[[Prothrombin time (PT)|Prothrombin time/International Normalized Ratio (INR)]] | **[[Prothrombin time (PT)|Prothrombin time/International Normalized Ratio (INR)]] | ||
**Metabolic profile (sodium, potassium, chloride, bicarbonate, blood urea nitrogen, creatinine, glucose, calcium, magnesium, phosphate, lactate dehydrogenase) | **Metabolic profile ([[sodium]], [[potassium]], [[chloride]], [[bicarbonate]], [[blood urea nitrogen]], [[creatinine]], [[glucose]], [[calcium]], [[magnesium]], [[phosphate]], [[lactate dehydrogenase]]) | ||
**[[Liver function tests]] (aspartate aminotransferase [AST], alanine aminotransferase [ALT], alkaline phosphatase, gamma-glutamyl transpeptidase [GGT], total and direct bilirubin, albumin) | **[[Liver function tests]] ([[Aspartate transaminase|aspartate aminotransferase]] [AST], [[alanine aminotransferase]] [ALT], [[alkaline phosphatase]], [[gamma-glutamyl transpeptidase]] [GGT], total and [[Bilirubin|direct bilirubin]], [[albumin]]) | ||
**[[Viral hepatitis]] serologies (hepatitis B surface antigen, anti-hepatitis B core IgM, hepatitis B virus DNA, anti-hepatitis C virus antibodies, hepatitis C virus RNA, anti-herpes simplex virus antibodies, CMV-specific IgM antibodies) | **[[Viral hepatitis]] serologies ([[hepatitis B surface antigen]], anti-hepatitis B core IgM, hepatitis B virus DNA, anti-hepatitis C virus antibodies, hepatitis C virus RNA, anti-herpes simplex virus antibodies, CMV-specific IgM antibodies) | ||
**[[Amylases|Amylase]] and [[lipase]] | **[[Amylases|Amylase]] and [[lipase]] | ||
Latest revision as of 16:09, 28 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Husnain Shaukat, M.D [2]
Overview
The patient with suspected sinusoidal obstruction syndrome (SOS) requires the following lab studies: complete blood count, liver function tests, complete metabolic profile and viral hepatitis serologies.
Laboratory Findings
The diagnosis of sinusoidal obstruction syndrome should be considered in any patient who has undergone hematopoietic stem cell transplant and develops liver dysfunction.
- The following tests can be performed in patients with suspected sinusoidal obstruction syndrome (SOS):[1][2][3]
- Complete blood count
- Prothrombin time/International Normalized Ratio (INR)
- Metabolic profile (sodium, potassium, chloride, bicarbonate, blood urea nitrogen, creatinine, glucose, calcium, magnesium, phosphate, lactate dehydrogenase)
- Liver function tests (aspartate aminotransferase [AST], alanine aminotransferase [ALT], alkaline phosphatase, gamma-glutamyl transpeptidase [GGT], total and direct bilirubin, albumin)
- Viral hepatitis serologies (hepatitis B surface antigen, anti-hepatitis B core IgM, hepatitis B virus DNA, anti-hepatitis C virus antibodies, hepatitis C virus RNA, anti-herpes simplex virus antibodies, CMV-specific IgM antibodies)
- Amylase and lipase
References
- ↑ McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, Hardin BJ, Shulman HM, Clift RA (1993). "Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients". Ann. Intern. Med. 118 (4): 255–67. PMID 8420443.
- ↑ Zager RA (1994). "Acute renal failure in the setting of bone marrow transplantation". Kidney Int. 46 (5): 1443–58. PMID 7853806.
- ↑ Hahn T, Rondeau C, Shaukat A, Jupudy V, Miller A, Alam AR, Baer MR, Bambach B, Bernstein Z, Chanan-Khan AA, Czuczman MS, Slack J, Wetzler M, Mookerjee BK, Silva J, McCarthy PL (2003). "Acute renal failure requiring dialysis after allogeneic blood and marrow transplantation identifies very poor prognosis patients". Bone Marrow Transplant. 32 (4): 405–10. doi:10.1038/sj.bmt.1704144. PMID 12900777.