Osteoarthritis risk factors: Difference between revisions
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Age plays an important roll in development of osteoarthritis. Higher age leads to decreasing in the tensile property of cartilage in articular cartilage in accumulation of glycation consequently it can cause mechanical failure | Age plays an important roll in development of osteoarthritis. Higher age leads to decreasing in the tensile property of cartilage in articular cartilage in accumulation of glycation consequently it can cause mechanical failure | ||
==== Genetics | ==== Genetics ==== | ||
Its been showed that genetic factors play important roles in developing of osteoarthritis. genetic factors are responsible for osteoarthritis in nearly 70%of cases. For example, osteocalcin, as a marker of bone turnover, decreases in women after their menopause which consequently women after menopause are more susceptible to knee arthritis. | Its been showed that genetic factors play important roles in developing of osteoarthritis. genetic factors are responsible for osteoarthritis in nearly 70%of cases. For example, osteocalcin, as a marker of bone turnover, decreases in women after their menopause which consequently women after menopause are more susceptible to knee arthritis. | ||
==== Diet ==== | ==== Diet ==== | ||
Using unrefined carbohydrates and Junk foods in daily diet increase the chance of chronic diseases. Meanwhile, chondrocytes as an important and powerful origin of reactive oxygen species (ROC). chondrocytes can damage cartilage collagen and synovial fluid hyaluronate. Meanwhile, micronutrients antioxidants, by providing defense against tissue injuries, are helpful to protect against osteoarthritis. | |||
=== Local risk factors for Osteoarthritis === | |||
==== Physical activity ==== | |||
Having an active physical activities and sports such as Karate | |||
In china women practicing gymnastic or kung fu (traditional | |||
Chinese martial arts) regularly were at the risk of Knee | |||
injury.25 Schematic diagram of risk factors in osteoarthritis is | |||
shown in Fig. 1. | |||
==== Joint injury and trauma ==== | |||
Articular cartilage tolerates loading from daily physical activities, | Articular cartilage tolerates loading from daily physical activities, | ||
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bone.22 | bone.22 | ||
==== Obesity ==== | |||
People with an elevated body mass index (BMI) as a measure | People with an elevated body mass index (BMI) as a measure | ||
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and damage to the knee joint.23 | and damage to the knee joint.23 | ||
==== Occupation ==== | |||
The lifting of heavy loads was found mainly in farmers, fishermen, | The lifting of heavy loads was found mainly in farmers, fishermen, | ||
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knee injury and osteoarthritis.24 | knee injury and osteoarthritis.24 | ||
*Aging | *Aging | ||
Revision as of 06:08, 29 March 2018
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Osteoarthritis Microchapters |
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Osteoarthritis risk factors On the Web |
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Risk calculators and risk factors for Osteoarthritis risk factors |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Risk Factors
Osteoarthritis is a multifactorial disease and the interactions between systemic and local factors play important role in development and prognosis of OA.
Systemic risk factors for Osteoarthritis
Gender
Previous studies reported that the frequency of osteoarthritis in women and men are 68% and 58% respectively. And it has been reported that women have a greater levels of pain and disability
Age
Age plays an important roll in development of osteoarthritis. Higher age leads to decreasing in the tensile property of cartilage in articular cartilage in accumulation of glycation consequently it can cause mechanical failure
Genetics
Its been showed that genetic factors play important roles in developing of osteoarthritis. genetic factors are responsible for osteoarthritis in nearly 70%of cases. For example, osteocalcin, as a marker of bone turnover, decreases in women after their menopause which consequently women after menopause are more susceptible to knee arthritis.
Diet
Using unrefined carbohydrates and Junk foods in daily diet increase the chance of chronic diseases. Meanwhile, chondrocytes as an important and powerful origin of reactive oxygen species (ROC). chondrocytes can damage cartilage collagen and synovial fluid hyaluronate. Meanwhile, micronutrients antioxidants, by providing defense against tissue injuries, are helpful to protect against osteoarthritis.
Local risk factors for Osteoarthritis
Physical activity
Having an active physical activities and sports such as Karate
In china women practicing gymnastic or kung fu (traditional
Chinese martial arts) regularly were at the risk of Knee
injury.25 Schematic diagram of risk factors in osteoarthritis is
shown in Fig. 1.
Joint injury and trauma
Articular cartilage tolerates loading from daily physical activities,
in joints injuries and trauma the cartilage loses its
flexibility, kills the cells and decrease the loading of the subchondral
bone.22
Obesity
People with an elevated body mass index (BMI) as a measure
of relative weight for obesity, has a positive association between
obesity and knee OA results in substantial overloading
and damage to the knee joint.23
Occupation
The lifting of heavy loads was found mainly in farmers, fishermen,
construction site workers, and general laborers.
Walking up stairs was experienced mainly by general laborers;
all of these stress activities causes the strong association between
knee injury and osteoarthritis.24
- Aging
- Obesity
- Trauma or surgery of joint
- Diabetes
- Other types of arthritis, such as gout or rheumatoid arthritis
- Congenital abnormalities