Churg-Strauss syndrome laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
===Blood work=== | ===Blood work=== | ||
* CBC with differential | * [[Complete blood count|CBC]] with differential | ||
** Leukocytosis with marked eosinophilia is present(>10% eosinophils/µL)<ref name="pmid16933465">{{cite journal |vauthors=Keogh KA, Specks U |title=Churg-Strauss syndrome: update on clinical, laboratory and therapeutic aspects |journal=Sarcoidosis Vasc Diffuse Lung Dis |volume=23 |issue=1 |pages=3–12 |date=March 2006 |pmid=16933465 |doi= |url=}}</ref><ref name="pmid2202307">{{cite journal |vauthors=Masi AT, Hunder GG, Lie JT, Michel BA, Bloch DA, Arend WP, Calabrese LH, Edworthy SM, Fauci AS, Leavitt RY |title=The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis) |journal=Arthritis Rheum. |volume=33 |issue=8 |pages=1094–100 |date=August 1990 |pmid=2202307 |doi= |url=}}</ref> | ** [[Leukocytosis]] with marked [[eosinophilia]] is present(>10% eosinophils/µL)<ref name="pmid16933465">{{cite journal |vauthors=Keogh KA, Specks U |title=Churg-Strauss syndrome: update on clinical, laboratory and therapeutic aspects |journal=Sarcoidosis Vasc Diffuse Lung Dis |volume=23 |issue=1 |pages=3–12 |date=March 2006 |pmid=16933465 |doi= |url=}}</ref><ref name="pmid2202307">{{cite journal |vauthors=Masi AT, Hunder GG, Lie JT, Michel BA, Bloch DA, Arend WP, Calabrese LH, Edworthy SM, Fauci AS, Leavitt RY |title=The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis) |journal=Arthritis Rheum. |volume=33 |issue=8 |pages=1094–100 |date=August 1990 |pmid=2202307 |doi= |url=}}</ref> | ||
** Anaemia | ** [[Anemia|Anaemia]] | ||
* Elevated BUN | * Elevated [[Blood urea nitrogen|BUN]] | ||
* Elevated serum creatinine | * Elevated [[Creatinine|serum creatinine]] | ||
* Raised ESR | * Raised [[Erythrocyte sedimentation rate|ESR]] | ||
* Elevated c-reactive protein | * Elevated [[c-reactive protein]] | ||
* Elevated troponin T<ref name="pmid23853013">{{cite journal |vauthors=McAleavey N, Millar A, Pendleton A |title=Cardiac involvement as the main presenting feature in eosinophilic granulomatosis with polyangiitis |journal=BMJ Case Rep |volume=2013 |issue= |pages= |date=July 2013 |pmid=23853013 |pmc=3736255 |doi=10.1136/bcr-2013-009394 |url=}}</ref> | * Elevated [[troponin T]]<ref name="pmid23853013">{{cite journal |vauthors=McAleavey N, Millar A, Pendleton A |title=Cardiac involvement as the main presenting feature in eosinophilic granulomatosis with polyangiitis |journal=BMJ Case Rep |volume=2013 |issue= |pages= |date=July 2013 |pmid=23853013 |pmc=3736255 |doi=10.1136/bcr-2013-009394 |url=}}</ref> | ||
===Urine analysis=== | ===Urine analysis=== | ||
* | * [[Proteinuria]] | ||
* Microscopic hematuria | * [[Microscopic hematuria]] | ||
* Red cell casts | * Red cell casts | ||
* Albuminuria | * [[Albuminuria]] | ||
* Abnormal sedimentation | * Abnormal sedimentation | ||
===Immunologic tests=== | ===Immunologic tests=== | ||
* Elevated levels of IgE<ref name="pmid20523791">{{cite journal |vauthors=Choi JH, Ahn IS, Lee HB, Park CW, Lee CH, Ahn HK |title=A case of churg-strauss syndrome |journal=Ann Dermatol |volume=21 |issue=2 |pages=213–6 |date=May 2009 |pmid=20523791 |pmc=2861222 |doi=10.5021/ad.2009.21.2.213 |url=}}</ref> | * Elevated levels of [[Immunoglobulin E|IgE]]<ref name="pmid20523791">{{cite journal |vauthors=Choi JH, Ahn IS, Lee HB, Park CW, Lee CH, Ahn HK |title=A case of churg-strauss syndrome |journal=Ann Dermatol |volume=21 |issue=2 |pages=213–6 |date=May 2009 |pmid=20523791 |pmc=2861222 |doi=10.5021/ad.2009.21.2.213 |url=}}</ref> | ||
* Elevated levels of rheumatoid factor at low titer | * Elevated levels of [[rheumatoid factor]] at low titer | ||
* Hypergammaglobulinemia | * [[Hypergammaglobulinemia]] | ||
* C3, C4 levels may be normal or elevated | * [[C3 (complement)|C3]], C4 levels may be normal or elevated | ||
* Increased levels of eosinophil cationic protein<ref name="pmid23428926">{{cite journal |vauthors=Hara T, Yamaguchi K, Iwase T, Kadota M, Bando M, Ogasawara K, Bando S, Ise T, Niki T, Ueda Y, Tomita N, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Sata M |title=Eosinophilic myocarditis due to Churg-Strauss syndrome with markedly elevated eosinophil cationic protein |journal=Int Heart J |volume=54 |issue=1 |pages=51–3 |date=2013 |pmid=23428926 |doi= |url=}}</ref> | * Increased levels of [[eosinophil cationic protein]]<ref name="pmid23428926">{{cite journal |vauthors=Hara T, Yamaguchi K, Iwase T, Kadota M, Bando M, Ogasawara K, Bando S, Ise T, Niki T, Ueda Y, Tomita N, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Sata M |title=Eosinophilic myocarditis due to Churg-Strauss syndrome with markedly elevated eosinophil cationic protein |journal=Int Heart J |volume=54 |issue=1 |pages=51–3 |date=2013 |pmid=23428926 |doi= |url=}}</ref> | ||
Revision as of 23:55, 9 April 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [2]
Overview
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
OR
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
OR
[Test] is usually normal for patients with [disease name].
OR
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
OR
There are no diagnostic laboratory findings associated with [disease name].
Laboratory Findings
Blood work
- CBC with differential
- Leukocytosis with marked eosinophilia is present(>10% eosinophils/µL)[1][2]
- Anaemia
- Elevated BUN
- Elevated serum creatinine
- Raised ESR
- Elevated c-reactive protein
- Elevated troponin T[3]
Urine analysis
- Proteinuria
- Microscopic hematuria
- Red cell casts
- Albuminuria
- Abnormal sedimentation
Immunologic tests
- Elevated levels of IgE[4]
- Elevated levels of rheumatoid factor at low titer
- Hypergammaglobulinemia
- C3, C4 levels may be normal or elevated
- Increased levels of eosinophil cationic protein[5]
References
- ↑ Keogh KA, Specks U (March 2006). "Churg-Strauss syndrome: update on clinical, laboratory and therapeutic aspects". Sarcoidosis Vasc Diffuse Lung Dis. 23 (1): 3–12. PMID 16933465.
- ↑ Masi AT, Hunder GG, Lie JT, Michel BA, Bloch DA, Arend WP, Calabrese LH, Edworthy SM, Fauci AS, Leavitt RY (August 1990). "The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis)". Arthritis Rheum. 33 (8): 1094–100. PMID 2202307.
- ↑ McAleavey N, Millar A, Pendleton A (July 2013). "Cardiac involvement as the main presenting feature in eosinophilic granulomatosis with polyangiitis". BMJ Case Rep. 2013. doi:10.1136/bcr-2013-009394. PMC 3736255. PMID 23853013.
- ↑ Choi JH, Ahn IS, Lee HB, Park CW, Lee CH, Ahn HK (May 2009). "A case of churg-strauss syndrome". Ann Dermatol. 21 (2): 213–6. doi:10.5021/ad.2009.21.2.213. PMC 2861222. PMID 20523791.
- ↑ Hara T, Yamaguchi K, Iwase T, Kadota M, Bando M, Ogasawara K, Bando S, Ise T, Niki T, Ueda Y, Tomita N, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Sata M (2013). "Eosinophilic myocarditis due to Churg-Strauss syndrome with markedly elevated eosinophil cationic protein". Int Heart J. 54 (1): 51–3. PMID 23428926.