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==Symptoms ==  
==Symptoms ==  
Symptoms vary depending on the type of disorder and the organs involved. Symptoms of cryoglobulinemia may include:
Symptoms vary depending on the type of cryoglobulinemia and the organs involved. Symptoms of cryoglobulinemia may include:
* [[Difficulty breathing]]
* [[Difficulty breathing]]
* Symptoms related to [[glomerulonephritis]] including [[hematuria|blood in urine]], [[proteinuria|foamy urine]], and [[edema]]
* Symptoms related to [[glomerulonephritis]] including [[hematuria|blood in urine]], [[proteinuria|foamy urine]], and [[edema]].
:* Renal disease occurs in 20% of patients at diagnosis and eventually develops in up to 60%, usually after the development of [[purpura]].
:* Renal involvement is more common in type II than in type III.
:* Renal involvement is more common in type II than in type III.
* [[Purpura]] or [[skin ulcer]]
* [[Purpura]] or [[skin ulcer]]
* [[Arthralgia]]
* [[Arthralgia]], specifically affecting metacarophangeal, proximal phalangeal, knees and ankles. It worsens with exposure to the cold.
* [[Myalgia]]
* [[Myalgia]]
* [[Fatigue]]
* [[Fatigue]]
* Blurring/loss of vision
* Diplopia
* Confusion
* Nonspecific constitutional symptoms
* Nonspecific constitutional symptoms



Revision as of 17:55, 23 April 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]Feham Tariq, MD [3]

Overview

History

Symptoms

Symptoms vary depending on the type of cryoglobulinemia and the organs involved. Symptoms of cryoglobulinemia may include:

  • Renal involvement is more common in type II than in type III.
  • Purpura or skin ulcer
  • Arthralgia, specifically affecting metacarophangeal, proximal phalangeal, knees and ankles. It worsens with exposure to the cold.
  • Myalgia
  • Fatigue
  • Blurring/loss of vision
  • Diplopia
  • Confusion
  • Nonspecific constitutional symptoms

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