Methemoglobinemia screening: Difference between revisions
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==Overview== | ==Overview== | ||
'''Congenital (Hereditary) Methemoglobinemia''' | |||
There are three main congenital conditions that lead to methemoglobinemia: | |||
1. Cytochrome b5 reductase deficiency and pyruvate kinase deficiency | |||
2. G6PD deficiency | |||
3. Presence of abnormal hemoglobin (Hb M) | |||
'''Acquired or Acute Methemoglobinemia''' | |||
Most common cause include different oxidant drugs, toxins or chemicals | |||
==Screening== | ==Screening== | ||
Revision as of 09:53, 29 April 2018
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Methemoglobinemia Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Methemoglobinemia screening On the Web |
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American Roentgen Ray Society Images of Methemoglobinemia screening |
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Risk calculators and risk factors for Methemoglobinemia screening |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:
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Overview
Congenital (Hereditary) Methemoglobinemia
There are three main congenital conditions that lead to methemoglobinemia:
1. Cytochrome b5 reductase deficiency and pyruvate kinase deficiency
2. G6PD deficiency
3. Presence of abnormal hemoglobin (Hb M)
Acquired or Acute Methemoglobinemia
Most common cause include different oxidant drugs, toxins or chemicals
Screening
Currently we have a screening test for G6PD deficiency. It is called methemoglobin reduction test (MRT), it is not expensive and it uses cord blood of neonates to check for the enzyme deficiency. Even though it has low sensitivity around 65%, it does have acceptable specificity arounf 90%.
- ↑ "pmid19032997" J Med Assoc Thai. 2001 Jun;84 Suppl 1:S91-8. The value of methemoglobin reduction test as a screening test for neonatal glucose 6-phosphate dehydrogenase deficiency. Sanpavat S1, Nuchprayoon I, Kittikalayawong A, Ungbumnet W.