Mixed connective tissue disease laboratory tests: Difference between revisions
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==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of MCTD include antibodies against the U1RNP, [[Rheumatoid factor|rheumatoid factor (RF)]], | Laboratory findings consistent with the diagnosis of MCTD include antibodies against the U1RNP, positive [[Rheumatoid factor|rheumatoid factor (RF)]], elevated [[C-reactive protein|CRP]] levels, [[hypergammaglobulinemia]], [[anemia]], [[Leukopenia|leucopenia]], circulating [[Immune complex|immune complexes]], and [[Complement deficiency|hypocomplementemia]]. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
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*Laboratory findings consistent with the diagnosis of MCTD include:<ref name="pmid16391886">{{cite journal |vauthors=Mimura Y, Ihn H, Jinnin M, Asano Y, Yamane K, Tamaki K |title=Rheumatoid factor isotypes in mixed connective tissue disease |journal=Clin. Rheumatol. |volume=25 |issue=4 |pages=572–4 |date=July 2006 |pmid=16391886 |doi=10.1007/s10067-005-0185-y |url=}}</ref><ref name="pmid15563821">{{cite journal |vauthors=Ruiz Pombo M, Labrador Horrillo M, Selva O'Callaghan A |title=[Undifferentiated, overlapping and mixed connective tissue diseases] |language=Spanish; Castilian |journal=Med Clin (Barc) |volume=123 |issue=18 |pages=712–7 |date=November 2004 |pmid=15563821 |doi= |url=}}</ref> | *Laboratory findings consistent with the diagnosis of MCTD include:<ref name="pmid16391886">{{cite journal |vauthors=Mimura Y, Ihn H, Jinnin M, Asano Y, Yamane K, Tamaki K |title=Rheumatoid factor isotypes in mixed connective tissue disease |journal=Clin. Rheumatol. |volume=25 |issue=4 |pages=572–4 |date=July 2006 |pmid=16391886 |doi=10.1007/s10067-005-0185-y |url=}}</ref><ref name="pmid15563821">{{cite journal |vauthors=Ruiz Pombo M, Labrador Horrillo M, Selva O'Callaghan A |title=[Undifferentiated, overlapping and mixed connective tissue diseases] |language=Spanish; Castilian |journal=Med Clin (Barc) |volume=123 |issue=18 |pages=712–7 |date=November 2004 |pmid=15563821 |doi= |url=}}</ref> | ||
**Antibodies against the U1-ribonucleoprotein complex (anti U1RNP) | **Antibodies against the U1-ribonucleoprotein complex (anti U1RNP) | ||
**[[Rheumatoid factor|Rheumatoid factor (RF)]] | **[[Rheumatoid factor|Rheumatoid factor (RF)]] positive | ||
** | **Elevated [[C-reactive protein|CRP]] levels<ref name="pmid9802936">{{cite journal |vauthors=Bakri Hassan A, Rönnelid J, Gunnarsson I, Karlsson G, Berg L, Lundberg I |title=Increased serum levels of immunoglobulins, C-reactive protein, type 1 and type 2 cytokines in patients with mixed connective tissue disease |journal=J. Autoimmun. |volume=11 |issue=5 |pages=503–8 |date=October 1998 |pmid=9802936 |doi=10.1006/jaut.1998.0236 |url=}}</ref> | ||
**[[Hypergammaglobulinemia]]<ref name="pmid8480140">{{cite journal |vauthors=Hämeenkorpi R, Ruuska P, Forsberg S, Tiilikainen R, Mäkitalo R, Hakala M |title=More evidence of distinctive features of mixed connective tissue disease |journal=Scand. J. Rheumatol. |volume=22 |issue=2 |pages=63–8 |date=1993 |pmid=8480140 |doi= |url=}}</ref> | **[[Hypergammaglobulinemia]]<ref name="pmid8480140">{{cite journal |vauthors=Hämeenkorpi R, Ruuska P, Forsberg S, Tiilikainen R, Mäkitalo R, Hakala M |title=More evidence of distinctive features of mixed connective tissue disease |journal=Scand. J. Rheumatol. |volume=22 |issue=2 |pages=63–8 |date=1993 |pmid=8480140 |doi= |url=}}</ref> | ||
**[[Complete blood count]] may shows:<ref name="pmid24353496">{{cite journal |vauthors=Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E |title=Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl |journal=Postepy Dermatol Alergol |volume=30 |issue=5 |pages=329–36 |date=October 2013 |pmid=24353496 |pmc=3858664 |doi=10.5114/pdia.2013.38365 |url=}}</ref> | **[[Complete blood count]] may shows:<ref name="pmid24353496">{{cite journal |vauthors=Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E |title=Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl |journal=Postepy Dermatol Alergol |volume=30 |issue=5 |pages=329–36 |date=October 2013 |pmid=24353496 |pmc=3858664 |doi=10.5114/pdia.2013.38365 |url=}}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]
Overview
Laboratory findings consistent with the diagnosis of MCTD include antibodies against the U1RNP, positive rheumatoid factor (RF), elevated CRP levels, hypergammaglobulinemia, anemia, leucopenia, circulating immune complexes, and hypocomplementemia.
Laboratory Findings
- Laboratory findings consistent with the diagnosis of MCTD include:[1][2]
- Antibodies against the U1-ribonucleoprotein complex (anti U1RNP)
- Rheumatoid factor (RF) positive
- Elevated CRP levels[3]
- Hypergammaglobulinemia[4]
- Complete blood count may shows:[5]
- Circulating immune complexes
- Hypocomplementemia
References
- ↑ Mimura Y, Ihn H, Jinnin M, Asano Y, Yamane K, Tamaki K (July 2006). "Rheumatoid factor isotypes in mixed connective tissue disease". Clin. Rheumatol. 25 (4): 572–4. doi:10.1007/s10067-005-0185-y. PMID 16391886.
- ↑ Ruiz Pombo M, Labrador Horrillo M, Selva O'Callaghan A (November 2004). "[Undifferentiated, overlapping and mixed connective tissue diseases]". Med Clin (Barc) (in Spanish; Castilian). 123 (18): 712–7. PMID 15563821.
- ↑ Bakri Hassan A, Rönnelid J, Gunnarsson I, Karlsson G, Berg L, Lundberg I (October 1998). "Increased serum levels of immunoglobulins, C-reactive protein, type 1 and type 2 cytokines in patients with mixed connective tissue disease". J. Autoimmun. 11 (5): 503–8. doi:10.1006/jaut.1998.0236. PMID 9802936.
- ↑ Hämeenkorpi R, Ruuska P, Forsberg S, Tiilikainen R, Mäkitalo R, Hakala M (1993). "More evidence of distinctive features of mixed connective tissue disease". Scand. J. Rheumatol. 22 (2): 63–8. PMID 8480140.
- ↑ Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E (October 2013). "Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl". Postepy Dermatol Alergol. 30 (5): 329–36. doi:10.5114/pdia.2013.38365. PMC 3858664. PMID 24353496.