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{{CMG}}; {{AE}}{{CK}}{{MJ}}
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''


==Overview==
{{Psoriatic arthritis}}
Psoriatic arthritis is a [[systemic]], immune- mediated inflammatory [[arthritis]], associated with [[psoriasis]]. The [[etiology]] is not clearly understood. It may be caused by complex interaction between [[Genetics|genetic]], [[Immune system|immunologic]] and environmental mechanisms which act as triggers for the [[disease]] development. Both psoriatic arthritis and [[psoriasis]] have been shown  to have strong familial predisposition.  Psoriatic arthritis present with [[pain]] and stiffness in the affected [[Joint|joints.]] According to Moll and Wright criteria, [[joint]] involvement pattern in psoriatic arthritis include distal [[arthritis]] usually involving distal interphalangeal joints, asymmetric [[oligoarthritis]], symmetric [[polyarthritis]], arthritis mutilans, [[spondylitis]], and [[sacroiliitis]]. Other [[Symptom|symptoms]] include [[Enthesopathy|enthesitis]] ([[pain]] and [[tenderness]] at the insertion of [[Tendon|tendons]] and [[Ligament|ligaments]] to the [[bone]]), [[dactylitis]] ( sausage like [[finger]] or [[toe]] swelling), [[Psoriasis|psoriatic skin plaques]], [[Nail (anatomy)|nail]] changes (pitting, [[hyperkeratosis]], and [[Nail (anatomy)|nail]] destruction). The [[pathophysiology]] of psoriatic arthritis consists of interactions between [[Cytokine|cytokines]], [[Dendritic cell|dendritic cells]], and [[T lymphocytes]]. Psoriatic arthritis must be differntiated from other inflammatory arthritides including [[rheumatoid arthritis]], [[ankylosing spondylitis]], [[reactive arthritis]], [[gout]], [[Chondrocalcinosis|pseudogout]], [[osteoarthritis]], [[arthritis]] associated with [[inflammatory bowel disease]]. The [[prevalence]] of [[Psoriatic arthritis (patient information)|psoriatic arthritis]] in general population ranges from 60 - 250 cases per 100,000 individuals and the [[prevalence]] of psoriatic arthritis among [[psoriasis]] patients is 11,000 per 100,000 individuals. The mainstay of therapy for psoriatic arthritis [[Non-steroidal anti-inflammatory drug|NSAIDs]],  conventional [[Disease-modifying antirheumatic drug|DMARDs]] (eg, [[methotrexate]], [[sulfasalazine]], [[cyclosporine]]) and biologic [[Disease-modifying antirheumatic drug|DMARDs]] (eg, [[TNF inhibitor|TNF inhibitors]]),  anti IL therapy (eg,  secukinumab, ustekinumab). Other treatment options include physiotherapy, patient education about disease and joint preservation and surgery. Psoriatic arthritis is associated with a number of [[Comorbidity|comorbid]] conditions due to circulating [[Antibody|immunoglobulins]], [[antibodies]] including [[metabolic syndrome]], increased [[insulin]] resistance, [[atherosclerosis]], [[stroke]], [[hypertension]], [[uveitis]], [[osteoporosis]] and [[depression]]. Patients are monitored regularly for [[disease]] activity, [[:Category:Drugs|drug]] efficacy, [[Adverse effect (medicine)|adverse effects]] and associated [[Comorbidity|comorbid conditions]].
{{CMG}}; {{AE}} {{CK}}, {{MJ}}
 
{{SK}} [[Rheumatoid disease]]
===Click here for [[The Heart in Psoriatic arthritis]]===
 
==[[Psoriatic arthritis overview|Overview]]==
 
==[[Psoriatic arthritis historical perspective|Historical Perspective]]==
 
==[[Psoriatic arthritis classification|Classification]]==
 
==[[Psoriatic arthritis pathophysiology|Pathophysiology]]==
 
==[[Psoriatic arthritis causes|Causes]]==
 
==[[Psoriatic arthritis differential diagnosis|Differentiating Psoriatic arthritis from Other Diseases]]==
 
==[[Psoriatic arthritis epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Psoriatic arthritis risk factors|Risk Factors]]==
 
==[[Psoriatic arthritis screening|Screening]]==
 
==[[Psoriatic arthritis natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
 
==Diagnosis==
[[Psoriatic arthritis diagnostic study of choice |Diagnostic study of choice]] | [[Psoriatic arthritis history and symptoms|History and Symptoms]] | [[Psoriatic arthritis physical examination|Physical Examination]] | [[Psoriatic arthritis laboratory tests|Laboratory Findings]] | [[Psoriatic arthritis electrocardiogram|Electrocardiogram]] | [[Rheumatoid arthritis x ray|X ray]] | [[Rheumatoid arthritis echocardiography and ultrasound|Echocardiography and Ultrasound]] | [[Psoriatic arthritis CT|CT]] | [[Psoriatic arthritis MRI|MRI Findings]] | [[Psoriatic arthritis other imaging findings|Other Imaging Findings]] | [[Psoriatic arthritis other diagnostic studies|Other Diagnostic Studies]]
 
==Treatment==
[[Psoriatic arthritis medical therapy|Medical Therapy]] |  [[Psoriatic arthritis surgical therapy|Surgical Therapy]]  | [[Psoriatic arthritis Primary prevention|Primary prevention]] | [[Psoriatic arthritis secondary prevention|Secondary prevention]] | [[Psoriatic arthritis future or investigational therapies|Future or Investigational Therapies]]
 
==Case Studies==
:[[Psoriatic arthritis case study 1|Case #1]]
 
==Related Chapters==
 
 
{{Diseases of the musculoskeletal system and connective tissue}}
 
[[Category:Arthritis]]
[[Category:Autoimmune diseases]]
[[Category:Rheumatology]]
[[Category:Primary care]]
 
{{WH}}
{{WS}}
e)|adverse effects]] and associated [[Comorbidity|comorbid conditions]].

Revision as of 14:17, 9 May 2018


For patient information click here

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [2], Mehrian Jafarizade, M.D [3]

Synonyms and keywords: Rheumatoid disease

Click here for The Heart in Psoriatic arthritis

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Psoriatic arthritis from Other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic study of choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X ray | Echocardiography and Ultrasound | CT | MRI Findings | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgical Therapy | Primary prevention | Secondary prevention | Future or Investigational Therapies

Case Studies

Case #1

Related Chapters

Template:Diseases of the musculoskeletal system and connective tissue

Template:WH Template:WS e)|adverse effects]] and associated comorbid conditions.

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