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==Overview==
==Overview==


'''Congenital (Hereditary) Methemoglobinemia'''
Methemoglobinemia presents with very distinct physical presentation.


There are three main [[congenital]] conditions that lead to [[methemoglobinemia]]:
==Physical Examination==
 
1. [[Cytochrome b5 reductase deficiency]] and [[pyruvate kinase deficiency]]
 
2. [[G6PD deficiency]]


3. Presence of abnormal [[hemoglobin]].
*Methemoglobinemia patients can present with different shades of bluish skin color, depending on the levels of MetHb in the blood. J Emerg Med. 2010 Jun;38(5):601-6. doi: 10.1016/j.jemermed.2008.06.025. Epub 2008 Dec 20.
Severe methemoglobinemia linked to gel-type topical benzocaine use: a case report.
Chung NY1, Batra R, Itzkevitch M, Boruchov D, Baldauf M. PMID: 19097728


*High methemoglobin levels in arterial blood causes the characteristic chocolate-brown color of the blood as compared to normal bright red oxygen-containing arterial blood.
Clin Toxicol (Phila). 2014 Sep-Oct;52(8):897-900. doi: 10.3109/15563650.2014.947377. Epub 2014 Aug 12.
Severe methemoglobinemia due to ingestion of toxicants.
D'sa SR1, Victor P, Jagannati M, Sudarsan TI, Carey RA, Peter JV. PMID: 25116418


'''Acquired or Acute Methemoglobinemia'''
Most common cause include different [[oxidant drugs]], toxins or chemicals
==Physical Examination==
The patient’s skin will have bluish hue and his blood will have brown-chocolate color.


==References==
==References==

Revision as of 14:55, 15 May 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Template:Aksiniya K. Stevasarova, M.D.

Overview

Methemoglobinemia presents with very distinct physical presentation.

Physical Examination

  • Methemoglobinemia patients can present with different shades of bluish skin color, depending on the levels of MetHb in the blood. J Emerg Med. 2010 Jun;38(5):601-6. doi: 10.1016/j.jemermed.2008.06.025. Epub 2008 Dec 20.

Severe methemoglobinemia linked to gel-type topical benzocaine use: a case report. Chung NY1, Batra R, Itzkevitch M, Boruchov D, Baldauf M. PMID: 19097728

  • High methemoglobin levels in arterial blood causes the characteristic chocolate-brown color of the blood as compared to normal bright red oxygen-containing arterial blood.

Clin Toxicol (Phila). 2014 Sep-Oct;52(8):897-900. doi: 10.3109/15563650.2014.947377. Epub 2014 Aug 12. Severe methemoglobinemia due to ingestion of toxicants. D'sa SR1, Victor P, Jagannati M, Sudarsan TI, Carey RA, Peter JV. PMID: 25116418


References

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