Urethral cancer pathophysiology: Difference between revisions
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* [[Male]] | * [[Male]] | ||
:* The [[male]] [[urethra]] is lined by [[transitional]] cells in its [[prostatic]] and [[Membranous glomerulonephritis|membranous]] portion and [[stratified]] [[Columnar epithelia|columnar]] [[epithelium]] to stratified squamous epithelium in the [[Bulbous nose|bulbous]] and [[Penile discharge|penile]] portions. The submucosa of the urethra contains numerous glands. Therefore, [[Urethral cancer|urethral]] cancer in the male can manifest the histological characteristics of [[transitional cell carcinoma]], [[squamous cell carcinoma]], or [[adenocarcinoma]]. | :* The [[male]] [[urethra]] is lined by [[transitional]] cells in its [[prostatic]] and [[Membranous glomerulonephritis|membranous]] portion and [[stratified]] [[Columnar epithelia|columnar]] [[epithelium]] to [[stratified squamous epithelium]] in the [[Bulbous nose|bulbous]] and [[Penile discharge|penile]] portions. The [[submucosa]] of the [[urethra]] contains numerous glands. Therefore, [[Urethral cancer|urethral]] cancer in the [[male]] can manifest the histological characteristics of [[transitional cell carcinoma]], [[squamous cell carcinoma]], or [[adenocarcinoma]]. | ||
:* Except for the [[prostatic urethra]], where [[transitional cell carcinoma]] is most common, [[squamous cell carcinoma]] is the predominant [[histology]] of [[urethral]] [[neoplasms]]. [[Transitional cell carcinoma]] of the [[prostatic urethra]] may be associated with [[transitional cell carcinoma]] of the [[bladder]] and/or [[transitional cell]] [[carcinoma]] arising in [[prostatic ducts]]. | :* Except for the [[prostatic urethra]], where [[transitional cell carcinoma]] is most common, [[squamous cell carcinoma]] is the predominant [[histology]] of [[urethral]] [[neoplasms]]. [[Transitional cell carcinoma]] of the [[prostatic urethra]] may be associated with [[transitional cell carcinoma]] of the [[bladder]] and/or [[transitional cell]] [[carcinoma]] arising in [[prostatic ducts]]. | ||
Revision as of 14:15, 16 May 2018
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Urethral cancer Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]
Overview
The pathophysiology of urethral cancer depends on the histological subtypes.
Microscopic Pathology
- The female urethra is lined by transitional cell mucosa proximally and stratified squamous cells distally. Therefore, transitional cell carcinoma is most common in the proximal urethra and squamous cell carcinoma predominates in the distal urethra. Adenocarcinoma may occur in both locations and arises from metaplasia of the numerous periurethral glands.
- The male urethra is lined by transitional cells in its prostatic and membranous portion and stratified columnar epithelium to stratified squamous epithelium in the bulbous and penile portions. The submucosa of the urethra contains numerous glands. Therefore, urethral cancer in the male can manifest the histological characteristics of transitional cell carcinoma, squamous cell carcinoma, or adenocarcinoma.
- Except for the prostatic urethra, where transitional cell carcinoma is most common, squamous cell carcinoma is the predominant histology of urethral neoplasms. Transitional cell carcinoma of the prostatic urethra may be associated with transitional cell carcinoma of the bladder and/or transitional cell carcinoma arising in prostatic ducts.