Kidney stone differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].

OR

[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].

Differentiating Nephrolithiasis from other Diseases

Nephrolithiasis should be differentiated from other conditions presenting with acute flank or upper abdominal pain, hematuria, nausea and vomiting. The differentials include the following:

Category	Disease	History	Signs and Symptoms											Physical Examination			Laboratory abnormalities
			Nausea/vomiting	Hematuria	Location of pain	Fever	Tachycardia	Hypotension	Hypertension	Anorexia	Constipation	Rebound tenderness	Urinary frequency/Urgency/Dysuria	Costovetebral angle tenderness	Pelvic Examination	Rectal Examination	Complete Blood Count (CBC)	Urinalysis	BUN	Creatinine	Stone analysis	Urine Beta- hCG	Abnormal Liver Function Tests (LFTs)	Serum Amylase/Lipase	Abdominal/Pelvic CT scan	Serum Parathyroid hormone levels (PTH)
Renal Pathology	Nephrolithiasis	Primary hyper parathyroidism Inadequate dietary calcium intake Hypercalciuria Hyperoxaluria Cystinuria Renal tubular acidosis Infection with urease producing bacteria (Ureaplasma urealyticum, Klebsiella, Protues)	+	+	Flank/back pain radiating to groin	-	+	-	-	+/-	-	-	+	-	-	-	-					-	-	-	Non-contrast CT scan may show stone as radiolucency	+/-
	Pyelonephritis	Urinary tract infection Immunocompromised state (Diabetes, immunosuppressive medications) Urinary tract obstruction History of pyelonephritis Pregnancy Presence of urinary catheter, stent, nephrostomy tube	+	+ (microscopic)	Costovertebral angle Positive renal punch sign	+	+	+	-	+/-	-	+	+	+	Uretheritis Vaginitis	-	Leukocytosis	Pyuria Positive leukocyte esterase			-	-	-	-	Globaly decreased contrast uptake  Foci from abscess pockets	-
	Renal infarct	Sickle cell disease or trait Thrombosis Trauma Hypertension Cardiac arrhythmia Coagulopathy Atherosclerosis	+	+	Flank pain	+	+	-	+	-	-	-	-	-	-	-	Leukocytosis	Red blood cells Proteinuria			-	-				-
	Renal papillary necrosis	Analgesic use (Phenacetin, acetaminophen, NSAIDs) Pyelonephritis Urinary tract obstruction Sickle cell disease Tuberculosis Cirrhosis Diabetes Vasculitis Renal vein thrombosis	-	+ (microscopic)	Flank pain	+	+/-	-	+	-	-	-	+	-	-	-		Bacteriuria Pyuria Microscopic hematuria			-	-	-	-	Blunted renal calyces Contrast material–filled clefts in the renal medulla Non-enhanced lesions surrounded by rings of excreted contrast material Hyperattenuated medullary calcifications	-
	Renal cell carcinoma	Weight loss History of smoking Obesity Von-Hippel Lindau disease Night sweats Malaise Flank mass	+	+ (microscopic)	Flank pain	-	-	-	+	+	+/-	-	-	-	-	-	Anemia	Microscopic hemeturia Renal cell casts Urinary aquaporin-1 (AQP1) and adipophilin (ADFP)- proximal renal tubular cancer			-	-	-	-	Non-contrast CT: Lesions are soft tissue attenuation  Areas of calcification and necrosis Contrast-enhanced: Homogenous (small lesions) to irregular (large lesions) contrast enhancement	-
	Uretral stricture	Prior urinary tract surgery Congenital Urinary catheterization Direct penile trauma	-	+/-	-	-	-	-	-	-	-	-	+	-	-	-	-	-			-	-	-	-	-	-
Gynecological Pathology	Pelvic inflammatory disease	Endometritis Saplingitis Cesarian section Septic abortion Urinary tract infection Tuberculosis Actinomycosis	-	-	Right/left upper quadrant	+	+	+	-	+	-	-	+	-	Cervical motion tenderness Adnexal tenderness Foul smelling vaginal/urtetheral discharge	-	Leukocytosis	Bacteriuria (Neisseria gonorrhoeae or Chlamydia trachomatis, polymicrobial) Pyuria			-	-	-	-	Thickening of the uterosacral ligaments Haziness of the pelvic fat Periovarian stranding Enhancement of the adjacent peritoneum Thick-walled, complex fluid collection with septa formation (abscess pockets)	-
	Ovarian torsion	Sudden acute pain Sharp pain aggravated by walking Intermittent/colicky pain	+	-	Unilateral poorly localized lower abdominal	-	+	-	-	-	-	-	-	-	Adnexal tenderness Adnexal mass	-	-	-	-	-	-	-	-	-	Twisted ovarian pedicle Enlarged ovary (>4.0 cm) Distended pedicle Possible underlying ovarian lesion	-
	Ectopic pregnancy	History of previous ectopic pregnancy Tubal surgery Intrauterine device usage History of pelvic surgery History of pelvic inflammatory disease Sub-fertility Sternous excercise Increased maternal age Cigarette smoking	+	-	Lower abdominal Unilateral shoulder or neck pain (referred)	-	+	-	-	+	-	+ (if ruptured)	+	-	Vaginal bleeding	-	Low platelet distribution width (decreased platelet activation) Monocytosis	-	-	-	-	+	+/-	-	N/A	-
Prostate Pathology	Prostatitis	Bacterial infection by: Ureaplasma urealyticum Proteus Chlamydia Gonorrhea E.Coli Pseudomonas Mycoplasma Prior history of prostatitis Urinary tract infection Urinary catheterization	-	+	Perineal pain Lower back pain Suprapubic pain	+	+	-	-	-	-	-	+	-	-	Enlarged prostate Rectal pain	Leukocytosis	Bacteriuria Pyuria Microscopic hematuria	-	-	-	-	-	-		-
	Prostatic cancer	Family history of prostate cancer (1st degree relatives) Germline mutation of HOXB13 (G84E variant) Black ethnicity Age > 50 years	-	+	-	-	-	-	-	+	-	-	+	-	-	Enlarged prostate Firm and hard	-	Positive prostate specific antigen (PSA) High levels of TMPRSS2:ERG and PCA3			-	-	-	-	Focal areas of mass-like enhancement in the peripheral prostate Calcifications	-
Testicular Pathology	Testicular torsion	Age 12 - 16 years Previous history of testicular torsion Family history of testicular torsion Prematurity Undescended testes Low birth weight	+	-	Sudden onset unilateral testicular pain	-	+	-	-	+/-	-	-	+/-	-	Absent cremasteric reflex Testicle may be swollen, tender, and high-riding, with an abnormal transverse lie.	-	-	-	-	-	-	-	-	-	Doppler ultrasound > CT scan for diagnosis (abscence of blood flow in the affected testis)	-
	Orchitis	Unprotected sexual intercourse Mumps, coxsackie virus infection Concurrent epididymitis Congenital abnornmalities Prostatitis Prostatic hypertrophy or calculi	+	-	Abrupt onset of testicular pain	+	+	-	-	-	-	-	+/-	-	Testicular swelling and tenderness Normal cremasteric reflex	-	Leukocytosis	-	-	-	-	-	-	-	Ultrasound > CT scan for diagnosis (Testicular masses or swollen testicles with hypoechoic and hypervascular areas)	-
Abdominal Pathology	Cholecystitis	Female gender Obesity Pregnancy (increased progesterone promotes biliary stasis) Rapid weight loss Oral contraceptive use Increasing age Total parenteral nutrition	+	-	Right upper abdominal quadrant pain Flank pain	+	+	-	-	+	-	-	-	-	-	-	Leukocytosis	-	-	-	Bilirubin (pigment) stones Cholesterol stones	-	+	-	Gallbladder distention Wall thickening Mucosal hyperenhancement, Pericholecystic fat stranding or fluid Gallstones	-
	Appendicitis	Male gender Adolescents Diet low in fiber and high in refined carbohydrates History of appendicitis in first degree relatives
	Diverticulitis	Diverticulosis Low fiber diet Old age
	Abdominal aortic aneurysm	Hypertension Cigarette smoking
	Portal vein thrombosis	Mutated JAK2 V617F Anti-phospholipid syndrome Paroxysmal nocturnal hemoglobinuria Homocysteinuria Factor V Leiden Prothrombin mutation G20210A Protein C or S deficiency Oral contraceptive use Cirrhosis Pregnancy and post-partum
	Duodenal ulcer	Helicobacter pylori infection Tobacco smoking NSAID use EtOH use Older age Female gender Family history of duodenal ulcers
	Ischemic colitis	Age > 60 years Hemodialysis Hypertension Hypoalbuminemia Diabetes mellitus