Fanconi syndrome causes: Difference between revisions

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__NOTOC__
__NOTOC__
{{Fanconi syndrome}}
{{Fanconi syndrome}}
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{{CMG}}; {{AE}}  
{{CMG}}; {{AE}}  
==Overview==
==Overview==
Disease name] may be caused by [cause1], [cause2], or [cause3].
Fanconi syndrome could be the result or complication of various causes affecting the normal function of Proximal convoluted tubule (PCT) ; in a simple and useful classification method, the causes could be classified as:
* '''Genetic causes'''
** ''Accumulation of a toxic substance''  (e.g. Cystinosis, Tyrozinemia, Lysinuric Protein Intolerance, Glycogen Storage Diseases, Galactosemia, wilson, fructose intolerance)
** ''Energy provision failure'' (e.g. Mitochondriopathies) 
** ''Disruption of endocytosis and intra-cellular transport'' (e.g. ARC syndrome, Lowe syndrome and Dent disease).
* '''Environmental causes''' (e.g. Heavy metals exposure, Drugs, Chemotherapy)
* '''Acquired causes''' (e.g. Multiple myeloma, Amyloidosis, Paroxysmal nocturnal hemoglobinuria)


OR
==Causes==
===Genetic Causes===
* '''Accumulation of a toxic substance'''
** Cystinosis
*** The most common inherited cause of Fanconi syndrome in children
** Tyrozinemia
** Lysinuric Protein Intolerance
** Glycogen Storage Diseases
** Galactosemia
** Wilson
** Fructose intolerance


Common causes of [disease] include [cause1], [cause2], and [cause3].
=== '''Environmental causes''' ===
* Nephrotic syndrome
* Multiple myeloma
* Sjögren syndrome
* Renal transplantation
* Acute tubulointerstitial nephritis with uveitis (TINU) syndrome
* Autoimmune interstitial nephritis and membranous nephropathy
* Anorexia nervosa
* Untreated condition of distal renal tubular acidosis


OR
=== '''Acquired causes''' ===
* '''Drugs'''
** Anti-retroviral drugs
*** ''Adefovir''
*** ''Tenofovir''
*** ''Didanosine''
*** ''Cidofovir''


The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].
** Antibacterial Drugs
*** ''Tetracyclines''
*** ''Aminoglycosides''


OR
** Anticonvulsants
*** ''Valproic acid''
* '''Heavy metals'''
** ''Lead''
** ''cadmium''
** ''Mercury''
* '''Chemotherapy'''


The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click [[Pericarditis causes#Overview|here]].
** ''Alkylating and Platinating Agents''
*** ''Cisplatin''
*** ''Streptozocin''
*** ''Carboplatin''
*** ''Ifosfamide''


==Causes==
** ''Mercaptopurine''.
===Life-threatening Causes===
*Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of [[disease name]], however complications resulting from untreated [[disease name]] is common.
*Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
*[Cause] is a life-threatening cause of [disease].
 
===Common Causes===
[Disease name] may be caused by:
*[Cause1]
*[Cause2]
*[Cause3]
 
 
OR
 
 
*[Disease name] is caused by an infection with [pathogen name].
*[Pathogen name] is caused by [pathogen name].


===Less Common Causes===
===Less Common Causes===
Line 48: Line 74:
===Causes by Organ System===
===Causes by Organ System===


{|style="width:80%; height:100px" border="1"
{| style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
| style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
| style="width:75%" bgcolor="Beige" ; border="1" | No underlying causes
|-
|-
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
| bgcolor="LightSteelBlue" | '''Chemical/Poisoning'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Dental'''
| '''Dental'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Dermatologic'''
| '''Dermatologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| '''Drug Side Effect'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Endocrine'''
| '''Endocrine'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Environmental'''
| '''Environmental'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
| '''Gastroenterologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Genetic'''
| '''Genetic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Hematologic'''
| '''Hematologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Iatrogenic'''
| '''Iatrogenic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| '''Infectious Disease'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
| '''Musculoskeletal/Orthopedic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Neurologic'''
| '''Neurologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
| '''Nutritional/Metabolic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Oncologic'''
| '''Oncologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
| '''Ophthalmologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
| '''Overdose/Toxicity'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Psychiatric'''
| '''Psychiatric'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Pulmonary'''
| '''Pulmonary'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
| '''Renal/Electrolyte'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
| '''Rheumatology/Immunology/Allergy'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Sexual'''
| '''Sexual'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Trauma'''
| '''Trauma'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Urologic'''
| '''Urologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| '''Miscellaneous'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|}
|}


===Causes in Alphabetical Order===
===Causes in Alphabetical Order===

Revision as of 04:51, 5 June 2018


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Fanconi syndrome could be the result or complication of various causes affecting the normal function of Proximal convoluted tubule (PCT) ; in a simple and useful classification method, the causes could be classified as:

  • Genetic causes
    • Accumulation of a toxic substance (e.g. Cystinosis, Tyrozinemia, Lysinuric Protein Intolerance, Glycogen Storage Diseases, Galactosemia, wilson, fructose intolerance)
    • Energy provision failure (e.g. Mitochondriopathies)
    • Disruption of endocytosis and intra-cellular transport (e.g. ARC syndrome, Lowe syndrome and Dent disease).
  • Environmental causes (e.g. Heavy metals exposure, Drugs, Chemotherapy)
  • Acquired causes (e.g. Multiple myeloma, Amyloidosis, Paroxysmal nocturnal hemoglobinuria)

Causes

Genetic Causes

  • Accumulation of a toxic substance
    • Cystinosis
      • The most common inherited cause of Fanconi syndrome in children
    • Tyrozinemia
    • Lysinuric Protein Intolerance
    • Glycogen Storage Diseases
    • Galactosemia
    • Wilson
    • Fructose intolerance

Environmental causes

  • Nephrotic syndrome
  • Multiple myeloma
  • Sjögren syndrome
  • Renal transplantation
  • Acute tubulointerstitial nephritis with uveitis (TINU) syndrome
  • Autoimmune interstitial nephritis and membranous nephropathy
  • Anorexia nervosa
  • Untreated condition of distal renal tubular acidosis

Acquired causes

  • Drugs
    • Anti-retroviral drugs
      • Adefovir
      • Tenofovir
      • Didanosine
      • Cidofovir
    • Antibacterial Drugs
      • Tetracyclines
      • Aminoglycosides
    • Anticonvulsants
      • Valproic acid
  • Heavy metals
    • Lead
    • cadmium
    • Mercury
  • Chemotherapy
    • Alkylating and Platinating Agents
      • Cisplatin
      • Streptozocin
      • Carboplatin
      • Ifosfamide
    • Mercaptopurine.

Less Common Causes

Less common causes of disease name include:

  • [Cause1]
  • [Cause2]
  • [Cause3]

Genetic Causes

  • [Disease name] is caused by a mutation in the [gene name] gene.

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

List the causes of the disease in alphabetical order.

The unnamed parameter 2= is no longer supported. Please see the documentation for {{columns-list}}.
3

References

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