Leiomyosarcoma causes

Overview:

Exact cause of leiomyosarcoma is not clearly evident.

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Causes:

Exact cause of leiomyosarcoma is not clearly evident.However following points are considered regarding causes:

• Although not proven but some reasearchers believes that it could be a malignant transformation of the fibroid( leiomyoma).
• It may arise denovo or can be due to the genomic instability. However molecular mechanism of tumorigenesis driven by genomic and genetic aberration is yet to be elucidated.
• Over expression of the protooncogene C-myc is seen in 50% of the cases.
• Retinobalstoma gene discrepancies are also seen in 90% of cases.
• P16 chromosomal deletion causes loss of tumor suppression and so is involved in the development of leiomyosarcoma.
• P53 gene mutation is also frequently seen in uterine leiomyosarcoma.

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