Lead poisoning differential diagnosis: Difference between revisions
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==Overview== | ==Overview== | ||
[[Lead poisoning]] must be differentiated from [[megaloblastic anemia]], [[carpal tunnel syndrome]], [[Guillain–Barré syndrome]], [[renal colic]], [[appendicitis]], [[encephalitis]] in adults, and [[viral gastroenteritis]] in children.<ref name="Henretig061316"/>, [[constipation]], [[abdominal colic]], [[iron deficiency]], [[subdural hematoma]], [[neoplasms of the central nervous system]], emotional and behavior disorders, and [[intellectual disability]].<ref name="Mycyk05-463"/> | [[Lead poisoning]] must be differentiated from [[megaloblastic anemia]]<ref name="pmid17405745">{{cite journal| author=Fonte R, Agosti A, Scafa F, Candura SM| title=Anaemia and abdominal pain due to occupational lead poisoning. | journal=Haematologica | year= 2007 | volume= 92 | issue= 2 | pages= e13-4 | pmid=17405745 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17405745 }} </ref>, [[carpal tunnel syndrome]]<ref name="pmid19996545">{{cite journal| author=Dsouza HS, Dsouza SA, Menezes G, Thuppil V| title=Evaluation and treatment of wrist drop in a patient due to lead poisoning: case report. | journal=Ind Health | year= 2009 | volume= 47 | issue= 6 | pages= 677-80 | pmid=19996545 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19996545 }} </ref>, [[Guillain–Barré syndrome]], [[renal colic]], [[appendicitis]], [[encephalitis]] in adults, and [[viral gastroenteritis]] in children.<ref name="Henretig061316"/>, [[constipation]], [[abdominal colic]]<ref name="pmid17634699">{{cite journal| author=Shiri R, Ansari M, Ranta M, Falah-Hassani K| title=Lead poisoning and recurrent abdominal pain. | journal=Ind Health | year= 2007 | volume= 45 | issue= 3 | pages= 494-6 | pmid=17634699 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17634699 }} </ref>, [[iron deficiency]], [[subdural hematoma]], [[neoplasms of the central nervous system]], emotional and behavior disorders, and [[intellectual disability]].<ref name="Mycyk05-463"/> <ref name="pmid17718907">{{cite journal| author=Herman DS, Geraldine M, Venkatesh T| title=Evaluation, diagnosis, and treatment of lead poisoning in a patient with occupational lead exposure: a case presentation. | journal=J Occup Med Toxicol | year= 2007 | volume= 2 | issue= | pages= 7 | pmid=17718907 | doi=10.1186/1745-6673-2-7 | pmc=2000868 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17718907 }} </ref> | ||
==Differentiating [[Lead poisoning]] from other Diseases== | ==Differentiating [[Lead poisoning]] from other Diseases== | ||
*As [[lead poisoning]] manifests in a variety of clinical forms, differentiation must be established in accordance with the particular clinical symptom. | *As [[lead poisoning]] manifests in a variety of clinical forms, differentiation must be established in accordance with the particular clinical symptom. <ref name="pmid22468050">{{cite journal| author=D'souza HS, Dsouza SA, Menezes G, Venkatesh T| title=Diagnosis, evaluation, and treatment of lead poisoning in general population. | journal=Indian J Clin Biochem | year= 2011 | volume= 26 | issue= 2 | pages= 197-201 | pmid=22468050 | doi=10.1007/s12291-011-0122-6 | pmc=3107416 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22468050 }} </ref> | ||
**[[Sideroblastic anemia]] must be differentiated from other diseases that cause [[basophilic stippling]] like [[megaloblastic anemia]]<ref name="pmid17405745">{{cite journal| author=Fonte R, Agosti A, Scafa F, Candura SM| title=Anaemia and abdominal pain due to occupational lead poisoning. | journal=Haematologica | year= 2007 | volume= 92 | issue= 2 | pages= e13-4 | pmid=17405745 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17405745 }} </ref>. | |||
**[[Peripheral neuropathy]] must be differentiated from [[Guillain–Barré syndrome]], which will present with [[albuminocytological dissociation]] on [[CSF analysis]]. | |||
**[[Intellectual disability]] must be differentiated from [[autism]], [[Down syndrome]], [[Fragile X syndrome]] | |||
**[[Abdominal colic]] must be differentiated from [[Gallbladder disease]], [[viral gastroenteritis]], [[pancreatitis]] etc.<ref name="pmid17634699">{{cite journal| author=Shiri R, Ansari M, Ranta M, Falah-Hassani K| title=Lead poisoning and recurrent abdominal pain. | journal=Ind Health | year= 2007 | volume= 45 | issue= 3 | pages= 494-6 | pmid=17634699 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17634699 }} </ref> | |||
==References== | ==References== | ||
Revision as of 12:43, 17 June 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aksiniya K. Stevasarova, MD
Overview
Lead poisoning must be differentiated from megaloblastic anemia[1], carpal tunnel syndrome[2], Guillain–Barré syndrome, renal colic, appendicitis, encephalitis in adults, and viral gastroenteritis in children.[3], constipation, abdominal colic[4], iron deficiency, subdural hematoma, neoplasms of the central nervous system, emotional and behavior disorders, and intellectual disability.[5] [6]
Differentiating Lead poisoning from other Diseases
- As lead poisoning manifests in a variety of clinical forms, differentiation must be established in accordance with the particular clinical symptom. [7]
- Sideroblastic anemia must be differentiated from other diseases that cause basophilic stippling like megaloblastic anemia[1].
- Peripheral neuropathy must be differentiated from Guillain–Barré syndrome, which will present with albuminocytological dissociation on CSF analysis.
- Intellectual disability must be differentiated from autism, Down syndrome, Fragile X syndrome
- Abdominal colic must be differentiated from Gallbladder disease, viral gastroenteritis, pancreatitis etc.[4]
References
- ↑ 1.0 1.1 Fonte R, Agosti A, Scafa F, Candura SM (2007). "Anaemia and abdominal pain due to occupational lead poisoning". Haematologica. 92 (2): e13–4. PMID 17405745.
- ↑ Dsouza HS, Dsouza SA, Menezes G, Thuppil V (2009). "Evaluation and treatment of wrist drop in a patient due to lead poisoning: case report". Ind Health. 47 (6): 677–80. PMID 19996545.
- ↑
- ↑ 4.0 4.1 Shiri R, Ansari M, Ranta M, Falah-Hassani K (2007). "Lead poisoning and recurrent abdominal pain". Ind Health. 45 (3): 494–6. PMID 17634699.
- ↑
- ↑ Herman DS, Geraldine M, Venkatesh T (2007). "Evaluation, diagnosis, and treatment of lead poisoning in a patient with occupational lead exposure: a case presentation". J Occup Med Toxicol. 2: 7. doi:10.1186/1745-6673-2-7. PMC 2000868. PMID 17718907.
- ↑ D'souza HS, Dsouza SA, Menezes G, Venkatesh T (2011). "Diagnosis, evaluation, and treatment of lead poisoning in general population". Indian J Clin Biochem. 26 (2): 197–201. doi:10.1007/s12291-011-0122-6. PMC 3107416. PMID 22468050.