Urethral cancer pathophysiology: Difference between revisions
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==Microscopic Pathology== | ==Microscopic Pathology== | ||
* [[Female]] | * [[Female]]<ref name="pmid23608423">{{cite journal |vauthors=Cantiello F, Cicione A, Salonia A, Autorino R, Tucci L, Madeo I, Damiano R |title=Periurethral fibrosis secondary to prostatic inflammation causing lower urinary tract symptoms: a prospective cohort study |journal=Urology |volume=81 |issue=5 |pages=1018–23 |date=May 2013 |pmid=23608423 |doi=10.1016/j.urology.2013.01.053 |url=}}</ref> | ||
:* The [[female]] [[urethra]] is lined by [[transitional cell]] [[mucosa]] proximally and [[stratified]] [[squamous]] cells distally. Therefore, [[transitional cell carcinoma]] is most common in the [[proximal]] [[urethra]] and [[Squamous cell carcinoma laboratory tests|squamous cell carcinoma]] predominates in the distal [[urethra]]. [[Adenocarcinoma]] may occur in both locations and arises from [[metaplasia]] of the numerous [[Periurethral phlegmon|periurethral]] [[glands]]. | :* The [[female]] [[urethra]] is lined by [[transitional cell]] [[mucosa]] proximally and [[stratified]] [[squamous]] cells distally. Therefore, [[transitional cell carcinoma]] is most common in the [[proximal]] [[urethra]] and [[Squamous cell carcinoma laboratory tests|squamous cell carcinoma]] predominates in the distal [[urethra]]. [[Adenocarcinoma]] may occur in both locations and arises from [[metaplasia]] of the numerous [[Periurethral phlegmon|periurethral]] [[glands]]. | ||
Revision as of 19:48, 20 June 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]
Overview
The pathophysiology of urethral cancer depends on the histological subtypes.
Microscopic Pathology
- The female urethra is lined by transitional cell mucosa proximally and stratified squamous cells distally. Therefore, transitional cell carcinoma is most common in the proximal urethra and squamous cell carcinoma predominates in the distal urethra. Adenocarcinoma may occur in both locations and arises from metaplasia of the numerous periurethral glands.
- The male urethra is lined by transitional cells in its prostatic and membranous portion and stratified columnar epithelium to stratified squamous epithelium in the bulbous and penile portions. The submucosa of the urethra contains numerous glands. Therefore, urethral cancer in the male can manifest the histological characteristics of transitional cell carcinoma, squamous cell carcinoma, or adenocarcinoma.
- Except for the prostatic urethra, where transitional cell carcinoma is most common, squamous cell carcinoma is the predominant histology of urethral neoplasms. Transitional cell carcinoma of the prostatic urethra may be associated with transitional cell carcinoma of the bladder and/or transitional cell carcinoma arising in prostatic ducts.
References
- ↑ Cantiello F, Cicione A, Salonia A, Autorino R, Tucci L, Madeo I, Damiano R (May 2013). "Periurethral fibrosis secondary to prostatic inflammation causing lower urinary tract symptoms: a prospective cohort study". Urology. 81 (5): 1018–23. doi:10.1016/j.urology.2013.01.053. PMID 23608423.