Rapidly progressive glomerulonephritis diagnostic study of choice: Difference between revisions
Jump to navigation
Jump to search
Nazia Fuad (talk | contribs) |
Nazia Fuad (talk | contribs) |
||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{Rapidly progressive glomerulonephritis}} | {{Rapidly progressive glomerulonephritis}} | ||
{{CMG}}; {{APM}} {{AE}} {{KW}}, {{ADS}}, {{AEL}} | {{CMG}}; {{APM}} {{AE}} {{KW}}, {{ADS}}, | ||
{{AEL}} | |||
==Overview== | ==Overview== | ||
| Line 18: | Line 20: | ||
** Tubular necrosis may also be present. | ** Tubular necrosis may also be present. | ||
** Interstitial granulomas in the glomeruli indicate Wegener’s granulomatosis. | ** Interstitial granulomas in the glomeruli indicate Wegener’s granulomatosis. | ||
===Immunoflourescence=== | =====Immunoflourescence===== | ||
*In type I RPGN- diffuse and linear deposition of [[Immunoglobulin G|IgG]] along the [[GBM]]. | *In type I RPGN- diffuse and linear deposition of [[Immunoglobulin G|IgG]] along the [[GBM]]. | ||
*In ttype II RPGN- diffuse and irregular deposition of IgG and C3 in the [[Mesangial cell|mesangial]] matrix. | *In ttype II RPGN- diffuse and irregular deposition of IgG and C3 in the [[Mesangial cell|mesangial]] matrix. | ||
*In type III RPGN- no finding. | *In type III RPGN- no finding. | ||
* | *'''Electron microscopy''' | ||
*In type I and type III, no electron dense deposits are seen. | |||
**In type II RPGN, subepithelial electron dense deposits indiacting the presence of [[Immune complex|immune complexes]] are seen. | |||
Serologic studies | ===== Serologic studies ===== | ||
*[[ Complete blood cell count]] (CBC) with[[ differential]], | *[[ Complete blood cell count]] (CBC) with[[ differential]], | ||
**[[ Anemia]] can be seen in patienst with [[renal failure]] or gastrointestinal tract bleeding. | **[[ Anemia]] can be seen in patienst with [[renal failure]] or gastrointestinal tract bleeding. | ||
** [[Eosinophilia]] | ** [[Eosinophilia]] greater than 13% suggest [[Churg-Strauss disease]]. | ||
* [[Serum electrolytes]] | * [[Serum electrolytes]] | ||
* BUN([[blood urea nitrogen)]] | * BUN([[blood urea nitrogen)]] | ||
| Line 41: | Line 44: | ||
* C-reactive protein: levels are elevated and correspond with disease activity. | * C-reactive protein: levels are elevated and correspond with disease activity. | ||
*[[ Antinuclear antibody]] (ANA).High ANA titer is present in systemic lupus erythematosus. | *[[ Antinuclear antibody]] (ANA).High ANA titer is present in systemic lupus erythematosus. | ||
. | . | ||
Revision as of 13:17, 24 July 2018
|
Rapidly progressive glomerulonephritis Microchapters |
|
Differentiating Rapidly progressive glomerulonephritis from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Rapidly progressive glomerulonephritis diagnostic study of choice On the Web |
|
American Roentgen Ray Society Images of Rapidly progressive glomerulonephritis diagnostic study of choice |
|
FDA on Rapidly progressive glomerulonephritis diagnostic study of choice |
|
CDC on Rapidly progressive glomerulonephritis diagnostic study of choice |
|
Rapidly progressive glomerulonephritis diagnostic study of choice in the news |
|
Blogs on Rapidly progressive glomerulonephritis diagnostic study of choice |
|
Directions to Hospitals Treating Rapidly progressive glomerulonephritis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3], Amandeep Singh M.D.[4],
Overview
Rapid diagnosis of rapidly progressive glomerulonephritis is very crucial to save kidneys function
Diagnostic study of choice:
Renal biopsy:
- Renal biopsy will provide the most accurate reslt.
- Renal biopsy will give accurate information about the extent of the disease and therapy can be planned accordingly.
results of Renal biopsy:
- Light microscopy reveals
- Diffuse inflammation in glomeruli with rupture and damage to glomerular basement membrane.
- Crescents are present in the Bowmans space.
- Renal vessels can show transmural vasculitis, with necrosis and lymphocyte infiltrates.
- Tubular necrosis may also be present.
- Interstitial granulomas in the glomeruli indicate Wegener’s granulomatosis.
Immunoflourescence
- In type I RPGN- diffuse and linear deposition of IgG along the GBM.
- In ttype II RPGN- diffuse and irregular deposition of IgG and C3 in the mesangial matrix.
- In type III RPGN- no finding.
- Electron microscopy
- In type I and type III, no electron dense deposits are seen.
- In type II RPGN, subepithelial electron dense deposits indiacting the presence of immune complexes are seen.
Serologic studies
- Complete blood cell count (CBC) withdifferential,
- Anemia can be seen in patienst with renal failure or gastrointestinal tract bleeding.
- Eosinophilia greater than 13% suggest Churg-Strauss disease.
- Serum electrolytes
- BUN(blood urea nitrogen)
- Serum creatinine
- Lactate dehydrogenase (LDH)
- Creatine phosphokinase (CPK),
- The most common abnormality is an increased serum creatinine level
- Urinalysis with microscopy: Proteinuria equal to or greater than 2-3 g in 24 hours.
- Microscopic hematuria
- Red cell casts indicates glomerular inflammation
- Erythrocyte sedimentation, elevated with active disease.
- C-reactive protein: levels are elevated and correspond with disease activity.
- Antinuclear antibody (ANA).High ANA titer is present in systemic lupus erythematosus.
.