Membranoproliferative glomerulonephritis causes: Difference between revisions
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==Causes== | ==Causes== | ||
=== life- threatning causes === | |||
There are no life-threatening causes of membranoproliferative glomerulonephritis. , however complications resulting from untreated membranoproliferative glomerulonephritis. is common. | |||
=== Common Causes === | |||
Common causes of [[Membranoproliferative glomerulonephritis|MPGN]] may include: | |||
* [[Immune complex]]–mediated disease | * [[Immune complex]]–mediated disease | ||
: | : | ||
:* [[Autoimmune disease]]<nowiki/>s<ref>{{Cite journal|last=H. Terence Cook and Matthew C. Pickering|first=|date=2014|title=Histopathology of MPGN and C3 glomerulopathies|url=|journal=NATURE REVIEWS NEPHROLOGY|volume=|pages=|via=}}</ref><ref>{{Cite journal|last=MICHELINE LEVY, MARIE-CLAIRE GUBLER, MIREILLE SICH, AGNES BEZIAU, AND RENE HABIB|first=|date=1978|title=lmmunopathology Glomerulonephritis of Membranoproliferative with Subendothelial Deposits|url=|journal=clinical immunology and immunopathology|volume=|pages=|via=}}</ref><ref>{{Cite journal|last=Mårten Segelmark, Thomas Hellmark|first=|date=2010|title=Autoimmune kidney diseases|url=|journal=Elsevier|volume=|pages=|via=}}</ref> | :* [[Autoimmune disease]]<nowiki/>s<ref>{{Cite journal|last=H. Terence Cook and Matthew C. Pickering|first=|date=2014|title=Histopathology of MPGN and C3 glomerulopathies|url=|journal=NATURE REVIEWS NEPHROLOGY|volume=|pages=|via=}}</ref><ref>{{Cite journal|last=MICHELINE LEVY, MARIE-CLAIRE GUBLER, MIREILLE SICH, AGNES BEZIAU, AND RENE HABIB|first=|date=1978|title=lmmunopathology Glomerulonephritis of Membranoproliferative with Subendothelial Deposits|url=|journal=clinical immunology and immunopathology|volume=|pages=|via=}}</ref><ref>{{Cite journal|last=Mårten Segelmark, Thomas Hellmark|first=|date=2010|title=Autoimmune kidney diseases|url=|journal=Elsevier|volume=|pages=|via=}}</ref> | ||
:* | :** [[Systemic lupus erythematosus|Systemic lupus ery]]<nowiki/>[[Systemic lupus erythematosus|thematosus]] (SLE) | ||
:* | :** [[Sjögren's syndrome|Sjögren syndrome]] | ||
:* | |||
:* | :** [[Rheumatoid arthritis|Rheumatoid arthrit]]<nowiki/>[[Rheumatoid arthritis|is]] | ||
:** [[Scleroderma]] | |||
:* | :** [[Celiac disease|Cel]]<nowiki/>[[Celiac disease|iac disease]] | ||
:* Chronic infections | :* Chronic infections | ||
:* | :** [[Viral Hepatitis|Viral]] - [[Hepatitis B]], [[hepatitis C]], and [[Cryoglobulinemia|cryoglobulinemia type II]] | ||
:* | :** [[Bacterial]] - [[Endocarditis]], infected ventriculoatrial (or jugular) shunt, multiple visceral [[Abscess|abscesses]], [[leprosy]] | ||
:* | :** [[Protozoal]] - [[Malaria]][[Schistosomiasis|, schistosomiasis]] | ||
:* | :** Other infections - [[Mycoplasma]], [[Lyme disease|Lyme Disease]]<ref>{{Cite journal|last=Dimitrios Kirmizis, MD, Georgios Efstratiadis, MD, Dominiki Economidou, MD, Evdoxia Diza-Mataftsi, MD, Maria Leontsini, MD, and Dimitrios Memmos, MD|first=|date=2004|title=MPGN Secondary to Lyme Disease|url=|journal=American Journal of Kidney Diseases|volume=43|pages=|via=}}</ref> | ||
:* Miscellaneous - [[Chronic liver disease]] ([[cirrhosis]] and [[Alpha 1-antitrypsin deficiency|alpha1-antitrypsin deficiency]]) | :* Miscellaneous - [[Chronic liver disease]] ([[cirrhosis]] and [[Alpha 1-antitrypsin deficiency|alpha1-antitrypsin deficiency]]) | ||
* Chronic and recovered [[thrombotic microangiopathies]] | * Chronic and recovered [[thrombotic microangiopathies]] | ||
| Line 34: | Line 35: | ||
:* [[Sickle cell anemia]] and [[polycythemia]] | :* [[Sickle cell anemia]] and [[polycythemia]] | ||
:* Transplant [[glomerulopathy]] | :* Transplant [[glomerulopathy]] | ||
* [[Malignant]] [[Neoplasm|neoplasms]] | * [[Malignant]] [[Neoplasm|neoplasms]] | ||
:* [[Lymphoma]] | :* [[Lymphoma]] | ||
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:* [[Carcinoma]] | :* [[Carcinoma]] | ||
: | : | ||
=== Less Common Causes === | |||
Less common causes of MPGN include | |||
* [[Idiopathic]] forms of MPGN or of unknown association<ref>{{Cite journal|last=Fernando C. Fervenza, Sanjeev Sethi, and Richard J. Glassock|first=|date=2012|title=Idiopathic membranoproliferative glomerulonephritis: does it exist?|url=|journal=Nephrology Dialysis Transplantation ( NDT )|volume=|pages=|via=}}</ref> | |||
**MPGN type I | |||
**MPGN type II or dense deposit disease. | |||
**MPGN type III | |||
* [[Paraprotein]] deposition diseases | |||
** Glomerulonephropathies associated with [[cryoglobulinemia]] type I | |||
** Waldenström [[macroglobulinemia]] | |||
** Immunotactoid glomerulopathy | |||
** [[Immunoglobulin]] light chain or heavy chain deposition diseases | |||
** Fibrillary [[glomerulonephritis]] | |||
* Non-Hodgkin lymphoma | |||
* Renal cell carcinoma | |||
* Snake venom | |||
* Splenorenal shunt surgery for portal hypertension | |||
* Melanoma | |||
* Alpha-1-antitrypsin deficiency | |||
* Inherited complement deficiencies, specially C2 deficiency | |||
=== Genetic Causes === | |||
* MPGN is caused by a mutation in the complement factor H-related protein 5 (CFHR5) gene. | |||
===Causes by Organ System=== | ===Causes by Organ System=== | ||
{| style="width:80%; height:100px" border="1" | {| style="width:80%; height:100px" border="1" | ||
| style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular''' | | style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular''' | ||
| Line 83: | Line 105: | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
|'''Genetic''' | |'''Genetic''' | ||
| bgcolor="Beige" | | | bgcolor="Beige" |(CFHR5) gene mutation | ||
|- | |- | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
| Line 143: | Line 165: | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
|'''Rheumatology/Immunology/Allergy''' | |'''Rheumatology/Immunology/Allergy''' | ||
| bgcolor="Beige" | | | bgcolor="Beige" |[[Systemic lupus erythematosus|Systemic lupus ery]]<nowiki/>[[Systemic lupus erythematosus|thematosus]] (SLE) | ||
[[Sjögren's syndrome|Sjögren syndrome]] | |||
<nowiki/>[[Rheumatoid arthritis|Rheumatoid arthrit]]<nowiki/>[[Rheumatoid arthritis|is]] | |||
[[Scleroderma]] | |||
[[Celiac disease|Celia]]<nowiki/>[[Celiac disease|c disease]] | |||
|- | |- | ||
|- bgcolor="LightSteelBlue" | |- bgcolor="LightSteelBlue" | ||
Revision as of 14:41, 30 July 2018
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Membranoproliferative glomerulonephritis Microchapters |
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Differentiating Membranoproliferative glomerulonephritis from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Membranoproliferative glomerulonephritis causes On the Web |
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American Roentgen Ray Society Images of Membranoproliferative glomerulonephritis causes |
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Directions to Hospitals Treating Membranoproliferative glomerulonephritis |
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Risk calculators and risk factors for Membranoproliferative glomerulonephritis causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3] Nazia Fuad M.D.
Overview
There are multiples causes for membranoproliferative glomerulonephritis. Main are autoimmune diseases, mainly systemic lupus erythematosus (SLE), Sjögren syndrome, rheumatoid arthritis, inherited complement deficiencies (esp C2 deficiency), scleroderma, Celiac disease .Chronic infections also play major role such as viral infections like hepatitis B, hepatitis C, and cryoglobulinemia type II, bacterial infections such as endocarditis, infected ventriculoatrial (or jugular) shunt, multiple visceral abscesses, leprosy. Protozoal - malaria, schistosomiasis. Rare causes of MPGN include non-Hodgkin lymphoma, renal cell carcinoma, snake venom, splenorenal shunt surgery for portal hypertension , melanoma, alpha-1-antitrypsin deficiency, and cryoglobulinemic glomerulonephritis Idiopathic MPGN is a diagnosis of exclusion.
Causes
life- threatning causes
There are no life-threatening causes of membranoproliferative glomerulonephritis. , however complications resulting from untreated membranoproliferative glomerulonephritis. is common.
Common Causes
Common causes of MPGN may include:
- Immune complex–mediated disease
- Chronic infections
- Viral - Hepatitis B, hepatitis C, and cryoglobulinemia type II
- Bacterial - Endocarditis, infected ventriculoatrial (or jugular) shunt, multiple visceral abscesses, leprosy
- Protozoal - Malaria, schistosomiasis
- Other infections - Mycoplasma, Lyme Disease[4]
- Miscellaneous - Chronic liver disease (cirrhosis and alpha1-antitrypsin deficiency)
- Chronic infections
- Chronic and recovered thrombotic microangiopathies
- Healing phase of hemolytic uremic syndrome and/or thrombotic thrombocytopenic purpura
- Syndromes of circulating antiphospholipid (anticardiolipin) antibodies
- Radiation nephritis
- Nephropathy associated with bone marrow transplantation
- Sickle cell anemia and polycythemia
- Transplant glomerulopathy
Less Common Causes
Less common causes of MPGN include
- Idiopathic forms of MPGN or of unknown association[5]
- MPGN type I
- MPGN type II or dense deposit disease.
- MPGN type III
- Paraprotein deposition diseases
- Glomerulonephropathies associated with cryoglobulinemia type I
- Waldenström macroglobulinemia
- Immunotactoid glomerulopathy
- Immunoglobulin light chain or heavy chain deposition diseases
- Fibrillary glomerulonephritis
- Non-Hodgkin lymphoma
- Renal cell carcinoma
- Snake venom
- Splenorenal shunt surgery for portal hypertension
- Melanoma
- Alpha-1-antitrypsin deficiency
- Inherited complement deficiencies, specially C2 deficiency
Genetic Causes
- MPGN is caused by a mutation in the complement factor H-related protein 5 (CFHR5) gene.
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | (CFHR5) gene mutation |
| Hematologic | Sickle cell anemia and polycythemia |
| Iatrogenic | No underlying causes |
| Infectious Disease |
|
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | Lymphoma, leukemia, carcinoma |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | Systemic lupus erythematosus (SLE) |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
References
- ↑ H. Terence Cook and Matthew C. Pickering (2014). "Histopathology of MPGN and C3 glomerulopathies". NATURE REVIEWS NEPHROLOGY.
- ↑ MICHELINE LEVY, MARIE-CLAIRE GUBLER, MIREILLE SICH, AGNES BEZIAU, AND RENE HABIB (1978). "lmmunopathology Glomerulonephritis of Membranoproliferative with Subendothelial Deposits". clinical immunology and immunopathology.
- ↑ Mårten Segelmark, Thomas Hellmark (2010). "Autoimmune kidney diseases". Elsevier.
- ↑ Dimitrios Kirmizis, MD, Georgios Efstratiadis, MD, Dominiki Economidou, MD, Evdoxia Diza-Mataftsi, MD, Maria Leontsini, MD, and Dimitrios Memmos, MD (2004). "MPGN Secondary to Lyme Disease". American Journal of Kidney Diseases. 43.
- ↑ Fernando C. Fervenza, Sanjeev Sethi, and Richard J. Glassock (2012). "Idiopathic membranoproliferative glomerulonephritis: does it exist?". Nephrology Dialysis Transplantation ( NDT ).