Rapidly progressive glomerulonephritis history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
Despite the wide variety of diseases that cause RPGN, all types of RPGN are characterized by glomeruluar injury and the formation of crescents. Severe injury and GBM rupture leads to the leakage of [[plasma protein]]s through the GBM. Of these proteins, [[fibrin]] is thought to contribute most strongly to crescent formation. [[Epithelial cell]]s lining the [[Bowman capsule]] respond to the leaked fibrin and proliferate. Infiltrating [[white blood cell]]s such as [[monocyte]]s and [[macrophage]]s may also proliferate. These proliferating cells surround and compress the glomerulus, forming a crescent-shaped scar that is readily visible on [[light microscopy]] of a [[renal biopsy]]. | Despite the wide variety of diseases that cause RPGN, all types of RPGN are characterized by glomeruluar injury and the formation of crescents. Severe injury and GBM rupture leads to the leakage of [[plasma protein]]s through the GBM. Of these proteins, [[fibrin]] is thought to contribute most strongly to crescent formation. [[Epithelial cell]]s lining the [[Bowman capsule]] respond to the leaked fibrin and proliferate. Infiltrating [[white blood cell]]s such as [[monocyte]]s and [[macrophage]]s may also proliferate. These proliferating cells surround and compress the glomerulus, forming a crescent-shaped scar that is readily visible on [[light microscopy]] of a [[renal biopsy]]. | ||
==History == | ==History == | ||
Patients with rapidly progressive glomerulonephritis may have a positive history of<ref name="pmid12631105">{{cite journal |vauthors=Jennette JC |title=Rapidly progressive crescentic glomerulonephritis |journal=Kidney Int. |volume=63 |issue=3 |pages=1164–77 |date=March 2003 |pmid=12631105 |doi=10.1046/j.1523-1755.2003.00843.x |url=}}</ref> | |||
* Anuria | |||
* [[Oliguria]] | |||
* Macroscopic hematuria | |||
* Edema | |||
==Symptoms== | ==Symptoms== | ||
=== Common Symptoms<ref name="pmid12631105" /> === | |||
* | Common symptoms of [disease] include: | ||
* | * Malaise | ||
* Fever | |||
* Arthralgias | |||
* Myalgias | |||
* Anorexia | |||
* Weight loss | |||
* Macroscopic hematuria | |||
* Edema | |||
* Oliguria | |||
* Cough | |||
=== Less Common Symptoms<ref name="pmid12631105" /> === | |||
* Abdominal pain | |||
* Painful cutaneous nodules or ulcerations | |||
* Migratory polyarthropathy. | |||
Severe | *Severe [[hematuria]] | ||
*[[Dyspnea]] | |||
*[[ | |||
When the cause of RPGN is [[Goodpasture syndrome]] or [[vasculitis]] that involves the lungs (such as [[Wegener granulomatosis]]), | When the cause of RPGN is [[Goodpasture syndrome]] or [[vasculitis]] that involves the lungs (such as [[Wegener granulomatosis]]), patients may present with: | ||
*[[Cough]] | *[[Cough]] | ||
*[[Hemoptysis]] | *[[Hemoptysis]] | ||
Revision as of 18:42, 30 July 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.
Overview
Despite the wide variety of diseases that cause RPGN, all types of RPGN are characterized by glomeruluar injury and the formation of crescents. Severe injury and GBM rupture leads to the leakage of plasma proteins through the GBM. Of these proteins, fibrin is thought to contribute most strongly to crescent formation. Epithelial cells lining the Bowman capsule respond to the leaked fibrin and proliferate. Infiltrating white blood cells such as monocytes and macrophages may also proliferate. These proliferating cells surround and compress the glomerulus, forming a crescent-shaped scar that is readily visible on light microscopy of a renal biopsy.
History
Patients with rapidly progressive glomerulonephritis may have a positive history of[1]
- Anuria
- Oliguria
- Macroscopic hematuria
- Edema
Symptoms
Common Symptoms[1]
Common symptoms of [disease] include:
- Malaise
- Fever
- Arthralgias
- Myalgias
- Anorexia
- Weight loss
- Macroscopic hematuria
- Edema
- Oliguria
- Cough
Less Common Symptoms[1]
- Abdominal pain
- Painful cutaneous nodules or ulcerations
- Migratory polyarthropathy.
When the cause of RPGN is Goodpasture syndrome or vasculitis that involves the lungs (such as Wegener granulomatosis), patients may present with:
- Cough
- Hemoptysis
- Dyspnea
- Nasal bleeding, obstruction, or sinusitis.