Rapidly progressive glomerulonephritis history and symptoms: Difference between revisions
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==Symptoms== | ==Symptoms== | ||
=== Common Symptoms | === Common Symptoms === | ||
Common symptoms of [disease] include: | Common symptoms of [disease] include:<ref name="pmid12631105" /> | ||
* Malaise | * Malaise | ||
* Fever | * Fever | ||
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* Cough | * Cough | ||
=== Less Common Symptoms | === Less Common Symptoms === | ||
* Abdominal pain | * Abdominal pain | ||
* Painful cutaneous nodules or ulcerations | * Painful cutaneous nodules or ulcerations | ||
Revision as of 18:47, 30 July 2018
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Rapidly progressive glomerulonephritis Microchapters |
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Differentiating Rapidly progressive glomerulonephritis from other Diseases |
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Diagnosis |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.
Overview
Despite the wide variety of diseases that cause RPGN, all types of RPGN are characterized by glomeruluar injury and the formation of crescents. Severe injury and GBM rupture leads to the leakage of plasma proteins through the GBM. Of these proteins, fibrin is thought to contribute most strongly to crescent formation. Epithelial cells lining the Bowman capsule respond to the leaked fibrin and proliferate. Infiltrating white blood cells such as monocytes and macrophages may also proliferate. These proliferating cells surround and compress the glomerulus, forming a crescent-shaped scar that is readily visible on light microscopy of a renal biopsy.
History
Patients with rapidly progressive glomerulonephritis may have a positive history of[1]
- Anuria
- Oliguria
- Macroscopic hematuria
- Edema
Symptoms
Common Symptoms
Common symptoms of [disease] include:[1]
- Malaise
- Fever
- Arthralgias
- Myalgias
- Anorexia
- Weight loss
- Macroscopic hematuria
- Edema
- Oliguria
- Cough
Less Common Symptoms
- Abdominal pain
- Painful cutaneous nodules or ulcerations
- Migratory polyarthropathy.
When the cause of RPGN is Goodpasture syndrome or vasculitis that involves the lungs (such as Wegener granulomatosis), patients may present with:
- Cough
- Hemoptysis
- Dyspnea
- Nasal bleeding, obstruction, or sinusitis.