Rapidly progressive glomerulonephritis history and symptoms: Difference between revisions

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Revision as of 18:48, 30 July 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.

Patients with rapidly progressive glomerulonephritis may have a positive history of^[1]

Common symptoms of [disease] include:^[1]

When the cause of RPGN is Goodpasture syndrome or vasculitis that involves the lungs (such as Wegener granulomatosis), patients may present with:

↑ ^1.0 ^1.1 Jennette JC (March 2003). "Rapidly progressive crescentic glomerulonephritis". Kidney Int. 63 (3): 1164–77. doi:10.1046/j.1523-1755.2003.00843.x. PMID 12631105.

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 ==Overview==
-Despite the wide variety of diseases that cause RPGN, all types of RPGN are characterized by glomeruluar injury and the formation of crescents. Severe injury and GBM rupture leads to the leakage of [[plasma protein]]s through the GBM. Of these proteins, [[fibrin]] is thought to contribute most strongly to crescent formation. [[Epithelial cell]]s lining the [[Bowman capsule]] respond to the leaked fibrin and proliferate. Infiltrating [[white blood cell]]s such as [[monocyte]]s and [[macrophage]]s may also proliferate. These proliferating cells surround and compress the glomerulus, forming a crescent-shaped scar that is readily visible on [[light microscopy]] of a [[renal biopsy]].
 ==History  ==