Sideroblastic anemia epidemiology and demographics: Difference between revisions
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Hereditary sideroblastic anemia, being sex-linked, primarily affects males. | Hereditary sideroblastic anemia, being sex-linked, primarily affects males. | ||
• Primary acquired sideroblastic anemia is usually a disease of the elderly. | • Primary acquired sideroblastic anemia is usually a disease of the elderly.In 25 bone marrow biopsies of children younger than 13 years from Atlanta, Georgia (United States), with anemia, the prevalence of ringed sideroblasts was 8%. <sup>[50]</sup> | ||
In France, the prevalence of ringed sideroblasts was 57% in patients with primary MDS. <sup>[51]</sup> In the United Kingdom, amongst healthy volunteers undergoing bone marrow biopsy, siderotic granules (not ring sideroblasts) were present in 29% of men and 19% of women. <sup>[52]</sup> | |||
Although usually manifested in childhood, congenital X-linked sideroblastic anemia due to ''ALAS'' mutation can remain undiagnosed and then present late in the fourth to eighth decades of life. <sup>[53, 54]</sup> The median age of occurrence of primary acquired sideroblastic anemia is 74 years. <sup>[55]</sup> | |||
X-linked recessive types of sideroblastic anemia occur more commonly in males. A female would have to inherit 1 abnormal chromosome from each parent to acquire the disease. Progesterone and pregnancy have been reported to induce relapse of sideroblastic anemia. <sup>[</sup> | |||
==References== | ==References== | ||
Revision as of 15:32, 2 August 2018
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Overview
Epidemiology and Demographics
Hereditary sideroblastic anemia, being sex-linked, primarily affects males.
• Primary acquired sideroblastic anemia is usually a disease of the elderly.In 25 bone marrow biopsies of children younger than 13 years from Atlanta, Georgia (United States), with anemia, the prevalence of ringed sideroblasts was 8%. [50]
In France, the prevalence of ringed sideroblasts was 57% in patients with primary MDS. [51] In the United Kingdom, amongst healthy volunteers undergoing bone marrow biopsy, siderotic granules (not ring sideroblasts) were present in 29% of men and 19% of women. [52]
Although usually manifested in childhood, congenital X-linked sideroblastic anemia due to ALAS mutation can remain undiagnosed and then present late in the fourth to eighth decades of life. [53, 54] The median age of occurrence of primary acquired sideroblastic anemia is 74 years. [55]
X-linked recessive types of sideroblastic anemia occur more commonly in males. A female would have to inherit 1 abnormal chromosome from each parent to acquire the disease. Progesterone and pregnancy have been reported to induce relapse of sideroblastic anemia. [