Sideroblastic anemia differential diagnosis: Difference between revisions

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! colspan="2" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
! colspan="2" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
| colspan="6" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Clinical manifestations'''
| colspan="6" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Clinical manifestations'''
! colspan="12" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para-clinical findings
! colspan="8" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para-clinical findings
| colspan="1" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Gold standard'''
| colspan="1" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Gold standard'''
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Additional findings
|-
|-
| colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Symptoms'''
| colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Symptoms'''
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|-
|-
! colspan="8" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
! colspan="8" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histopathology
|-  
|-  
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptom 1
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptom 1
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!Iron in erythroblasts
!Iron in erythroblasts
!Iron stores in bone marrow
!Iron stores in bone marrow
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging 1
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging 2
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging 3
|-
|-
|
|
|Sideroblastic anemia
|Sideroblastic anemia
|
|Pallor
|
|Weaknes
|
|
|
|
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|present in ring form
|present in ring form
|present
|present
|
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|-
|-
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|Iron deficiency anemia
|Iron deficiency anemia
| style="background: #F5F5F5; padding: 5px;" |pallor
| style="background: #F5F5F5; padding: 5px;" |pallor
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |Jaundice
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
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|absent
|absent
|absent
|absent
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
|-
|-
|Thalasemia
|Thalasemia
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
 
| style="background: #F5F5F5; padding: 5px;" |
[[Jaundice]]
| style="background: #F5F5F5; padding: 5px;" |
 
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |jaundice
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |irritibility
| style="background: #F5F5F5; padding: 5px;" |Hpatomegaly
| style="background: #F5F5F5; padding: 5px;" |Splenomegaly
| style="background: #F5F5F5; padding: 5px;" |Growth retardation
| style="background: #F5F5F5; padding: 5px;" |micro/hypo with targeting
| style="background: #F5F5F5; padding: 5px;" |micro/hypo with targeting
| style="background: #F5F5F5; padding: 5px;" |Normal -high
| style="background: #F5F5F5; padding: 5px;" |Normal -high
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|present
|present
|present
|present
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
|-
|-
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|absent
|absent
|present
|present
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
|-
|-
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|
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| colspan="3" |
| colspan="3" |
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|
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| colspan="3" |
| colspan="3" |
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!
!
!
!
!Imaging 1
!Imaging 2
!Imaging 3
!Histopathology
|'''Gold standard'''
|'''Gold standard'''
!Additional findings
|-
|-
| rowspan="3" style="background: #DCDCDC; padding: 5px; text-align: center;" |Tissue iron overload
| rowspan="3" style="background: #DCDCDC; padding: 5px; text-align: center;" |Tissue iron overload
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| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
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| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
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|}
|}

Revision as of 17:55, 2 August 2018

Sideroblastic anemia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Sideroblastic Anemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Sideroblastic anemia differential diagnosis On the Web

Most recent articles

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.

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Overview

Differential Diagnosis

Sideroblastic anemia must be differentiated from other causes of microcytic hypochromic anemia: iron deficiency anemia, thalassemia, anemia of chronic disease, lead poisoning, and blood loss.

• Tissue iron overload from sideroblastic anemia may act similar to hereditary hemochromatosis with liver cirrhosis, diabetes, congestive heart failure, and cardiac arrhythmias.

  • ALA Dehydratase Deficiency Porphyria
  • Acute Myeloid Leukemia (AML)
  • Congenital Erythropoietic Porphyria
  • Hereditary Coproporphyria
  • Iron Deficiency Anemia
  • Myelodysplastic Syndrome
  • Secondary Thrombocytosis


On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].

Diseases Clinical manifestations Para-clinical findings Gold standard
Symptoms Physical examination
Lab Findings
Symptom 1 Symptom 2 Symptom 3 Physical exam 1 Physical exam 2 Physical exam 3 Peripheral blood smear Serum iron Serum TIBC Serum ferritin

g/L

Iron in erythroblasts Iron stores in bone marrow
Sideroblastic anemia Pallor Weaknes variable Normal -high Normal 50-300 present in ring form present
Microcytic hypochromic

anemia

Iron deficiency anemia pallor Jaundice microcytic/

hypochromic

<30 > 360 <15 absent absent
Thalasemia

Jaundice

jaundice irritibility Hpatomegaly Splenomegaly Growth retardation micro/hypo with targeting Normal -high Normal 50-300 present present
Anemia of chronic disease Normal Low <300 30-200 absent present
Lead poisoning
Blood loss
Diseases Symptom 1 Symptom 2 Symptom 3 Physical exam 1 Physical exam 2 Physical exam 3 Lab 1 Lab 2 Lab 3 Gold standard
Tissue iron overload

References

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