Sideroblastic anemia differential diagnosis: Difference between revisions

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Revision as of 18:53, 2 August 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.

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Overview

Differential Diagnosis

Sideroblastic anemia must be differentiated from other causes of microcytic hypochromic anemia: iron deficiency anemia, thalassemia, anemia of chronic disease, lead poisoning, and blood loss.

• Tissue iron overload from sideroblastic anemia may act similar to hereditary hemochromatosis with liver cirrhosis, diabetes, congestive heart failure, and cardiac arrhythmias.

ALA Dehydratase Deficiency Porphyria
Acute Myeloid Leukemia (AML)
Congenital Erythropoietic Porphyria
Hereditary Coproporphyria
Iron Deficiency Anemia
Myelodysplastic Syndrome
Secondary Thrombocytosis

On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].

		Symptoms			Physical examination			Lab Findings
Diseases		Clinical manifestations						Para-clinical findings						Gold standard
		Symptoms			Physical examination			Para-clinical findings
		Pallor	Weakness	Jaundice	Hepatomegaly	Splenomegaly	Growth retardation	Peripheral blood smear	Serum iron	Serum TIBC	Serum ferritin g/L	Iron in erythroblasts	Iron stores in bone marrow
	Sideroblastic anemia	+	+					variable	Normal -high	Normal	50-300	present in ring form	present
Microcytic hypochromic anemia	Iron deficiency anemia	pallor	Jaundice	+				microcytic/ hypochromic	<30	> 360	<15	absent	absent
	Thalasemia	Jaundice	jaundice	irritibility	Hpatomegaly	Splenomegaly	Growth retardation	micro/hypo with targeting	Normal -high	Normal	50-300	present	present
	Anemia of chronic disease							Normal	Low	<300	30-200	absent	present
	Lead poisoning
	Blood loss
Tissue iron overload

References

Template:WH Template:WS

@@ Line 33: / Line 33: @@
 ! colspan="8" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
 |-
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptom 1
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pallor
-! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptom 2
+! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Weakness
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptom 3
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physical exam 1
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepatomegaly
-! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physical exam 2
+! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physical exam 3
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Growth retardation
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Peripheral blood smear
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Serum iron
@@ Line 49: / Line 49: @@
 |
 |Sideroblastic anemia
-|Pallor
+| +
-|Weaknes
+| +
 |
 |
@@ Line 68: / Line 68: @@
 | style="background: #F5F5F5; padding: 5px;" |pallor
 | style="background: #F5F5F5; padding: 5px;" |Jaundice
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |+
 | style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |
@@ Line 84: / Line 84: @@
 |Thalasemia
 | style="background: #F5F5F5; padding: 5px;" |
 [[Jaundice]]
@@ Line 144: / Line 143: @@
 |
 |
-|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
-! colspan="2" |Diseases
-!Symptom 1
-! colspan="1" rowspan="1" |Symptom 2
-!Symptom 3
-!Physical exam 1
-! colspan="1" rowspan="1" |Physical exam 2
-!Physical exam 3
-!Lab 1
-!Lab 2
-!Lab 3
-!
-!
-!
-!
-!
-|'''Gold standard'''
 |-
 | rowspan="3" style="background: #DCDCDC; padding: 5px; text-align: center;" |Tissue iron overload

Sideroblastic anemia differential diagnosis: Difference between revisions

Revision as of 18:53, 2 August 2018

Overview

Differential Diagnosis

References

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