Paroxysmal nocturnal hemoglobinuria historical perspective: Difference between revisions
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{{ Paroxysmal nocturnal hemoglobinuria }} | {{Paroxysmal nocturnal hemoglobinuria }} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} | ||
==Overview== | ==Overview== | ||
==Historical Perspective== | ==Historical Perspective== | ||
===Discovery=== | ===Discovery=== | ||
* | *In the 19th century, the European physicians conducted observational studies which resulted in establishment of Paroxysmal Nocturnal Hemoglobinuria (PNH) as a separate disease from paroxysmal cold hemoglobinuria and march hemoglobinuria. | ||
*In 1815, Dr. Paul Strübing, a German physician, was the first to put the hypothesis of PNH. The hypothesis mentioned the abnormal hemolysis of the red blood cells due to increased plasma acidity in the night time.<ref>Strübing P. Paroxysmale Hämoglobinurie. ''Dtsch Med Wochenschr'' 1882;8:1-3 and 17-21.</ref><ref>[http://www.whonamedit.com/synd.cfm/2918.html Whonamedit entry]</ref> | |||
*Dr. Paul returned the abnormal hemolysis of the RBCs due to increased carbon dioxide gas as a result of the slow circulation nocturnally. | |||
*In | *In 1911, Dr. Ettore Marchiafava and Dr. Alessio Nazari added a more description about PNH.<ref>Marchiafava E, Nazari A. Nuovo contributo allo studio degli itteri cronici emolitici. ''Policlinico [Med]'' 1911;18:241-254.</ref> | ||
* | *In | ||
In | |||
==References== | ==References== | ||
Revision as of 16:24, 10 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Historical Perspective
Discovery
- In the 19th century, the European physicians conducted observational studies which resulted in establishment of Paroxysmal Nocturnal Hemoglobinuria (PNH) as a separate disease from paroxysmal cold hemoglobinuria and march hemoglobinuria.
- In 1815, Dr. Paul Strübing, a German physician, was the first to put the hypothesis of PNH. The hypothesis mentioned the abnormal hemolysis of the red blood cells due to increased plasma acidity in the night time.[1][2]
- Dr. Paul returned the abnormal hemolysis of the RBCs due to increased carbon dioxide gas as a result of the slow circulation nocturnally.
- In 1911, Dr. Ettore Marchiafava and Dr. Alessio Nazari added a more description about PNH.[3]
- In
References
- ↑ Strübing P. Paroxysmale Hämoglobinurie. Dtsch Med Wochenschr 1882;8:1-3 and 17-21.
- ↑ Whonamedit entry
- ↑ Marchiafava E, Nazari A. Nuovo contributo allo studio degli itteri cronici emolitici. Policlinico [Med] 1911;18:241-254.