Disseminated intravascular coagulation laboratory findings: Difference between revisions
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==Laboratory findings== | ==Laboratory findings== | ||
Laboratory findings consistent with the diagnosis of [[DIC]] include: | Laboratory findings consistent with the diagnosis of [[DIC]] include: | ||
=== Full blood count: === | === Full blood count: === | ||
* Decreased [[platelet|platelets]] | * Decreased [[platelet|platelets]] | ||
Revision as of 17:04, 19 September 2018
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Disseminated intravascular coagulation Microchapters |
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Differentiating Disseminated intravascular coagulation from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory findings
Laboratory findings consistent with the diagnosis of DIC include:
Full blood count:
- Decreased platelets
- fibrin degradation products or D-dimer tests (markers of fibrinolysis)
- bleeding time and fibrinogen levels.
Peripheral smear
- Schistocytes and RBC fragments in ~ 50%
- Mild reticulocytosis
- Leukocytosis
- Thrombocytopenia with an increased population of young platelets (due to increased destruction and turnover)
Clotting factors
- Normal prothrombin time and partial thromboplastin time in up to 50% of patients (due to higher circulating levels of clotting factors such as factor Xa and thrombin)
- Elevated fibrin and fibrinogen degradation products
- D-dimer more sensitive and specific for DIC.]
- Antithrombin levels have become a key test for diagnosing and monitoring therapy in DIC.
- Reduced Antithrombin levels.