Creutzfeldt-Jakob disease laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
Routine laboratory tests are usually normal in Creutzfeldt Jakob disease. Analysis of CSF for [[14-3-3 protein]] may be helpful in the diagnosis of Creutzfeldt-Jakob disease. | Routine laboratory tests are usually normal in Creutzfeldt Jakob disease. Analysis of [[CSF]] for [[14-3-3 protein]] may be helpful in the diagnosis of Creutzfeldt-Jakob disease. Other elevated proteins in [[CSF]] may include S-100, neuron specific [[enolase]], and [[Tau protein]]. | ||
==Laboratory Tests== | ==Laboratory Tests== | ||
* Routine laboratory tests are usually normal in Creutzfeldt Jakob disease. | * Routine laboratory tests are usually normal in Creutzfeldt Jakob disease. | ||
*[[Liver function tests]] may occasionally be elevated.<ref name="Tanaka-1992">{{Cite journal | last1 = Tanaka | first1 = M. | last2 = Iizuka | first2 = O. | last3 = Yuasa | first3 = T. | title = Hepatic dysfunction in Creutzfeldt-Jakob disease. | journal = Neurology | volume = 42 | issue = 6 | pages = 1249 | month = Jun | year = 1992 | doi = | PMID = 1302460 }}</ref> | *[[Liver function tests]] may occasionally be elevated.<ref name="Tanaka-1992">{{Cite journal | last1 = Tanaka | first1 = M. | last2 = Iizuka | first2 = O. | last3 = Yuasa | first3 = T. | title = Hepatic dysfunction in Creutzfeldt-Jakob disease. | journal = Neurology | volume = 42 | issue = 6 | pages = 1249 | month = Jun | year = 1992 | doi = | PMID = 1302460 }}</ref> | ||
* In CSF, elevated concentrations of following protein markers may be remarkable in Creutzfeldt-Jakob disease:<ref name="Sanchez-Juan-2006">{{Cite journal | last1 = Sanchez-Juan | first1 = P. | last2 = Green | first2 = A. | last3 = Ladogana | first3 = A. | last4 = Cuadrado-Corrales | first4 = N. | last5 = Sáanchez-Valle | first5 = R. | last6 = Mitrováa | first6 = E. | last7 = Stoeck | first7 = K. | last8 = Sklaviadis | first8 = T. | last9 = Kulczycki | first9 = J. | title = CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease. | journal = Neurology | volume = 67 | issue = 4 | pages = 637-43 | month = Aug | year = 2006 | doi = 10.1212/01.wnl.0000230159.67128.00 | PMID = 16924018 }}</ref> | * In [[CSF|CSF,]] elevated concentrations of following protein markers may be remarkable in Creutzfeldt-Jakob disease:<ref name="Sanchez-Juan-2006">{{Cite journal | last1 = Sanchez-Juan | first1 = P. | last2 = Green | first2 = A. | last3 = Ladogana | first3 = A. | last4 = Cuadrado-Corrales | first4 = N. | last5 = Sáanchez-Valle | first5 = R. | last6 = Mitrováa | first6 = E. | last7 = Stoeck | first7 = K. | last8 = Sklaviadis | first8 = T. | last9 = Kulczycki | first9 = J. | title = CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease. | journal = Neurology | volume = 67 | issue = 4 | pages = 637-43 | month = Aug | year = 2006 | doi = 10.1212/01.wnl.0000230159.67128.00 | PMID = 16924018 }}</ref> | ||
:* 14-3-3 protein | :* 14-3-3 protein | ||
:* S-100 | :* S-100 | ||
:* Neuron specific enolase | :* [[Enolase|Neuron specific enolase]] | ||
:* [[Tau protein]] | :* [[Tau protein]] | ||
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Revision as of 14:32, 25 October 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Routine laboratory tests are usually normal in Creutzfeldt Jakob disease. Analysis of CSF for 14-3-3 protein may be helpful in the diagnosis of Creutzfeldt-Jakob disease. Other elevated proteins in CSF may include S-100, neuron specific enolase, and Tau protein.
Laboratory Tests
- Routine laboratory tests are usually normal in Creutzfeldt Jakob disease.
- Liver function tests may occasionally be elevated.[1]
- In CSF, elevated concentrations of following protein markers may be remarkable in Creutzfeldt-Jakob disease:[2]
- 14-3-3 protein
- S-100
- Neuron specific enolase
- Tau protein
References
- ↑ Tanaka, M.; Iizuka, O.; Yuasa, T. (1992). "Hepatic dysfunction in Creutzfeldt-Jakob disease". Neurology. 42 (6): 1249. PMID 1302460. Unknown parameter
|month=ignored (help) - ↑ Sanchez-Juan, P.; Green, A.; Ladogana, A.; Cuadrado-Corrales, N.; Sáanchez-Valle, R.; Mitrováa, E.; Stoeck, K.; Sklaviadis, T.; Kulczycki, J. (2006). "CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease". Neurology. 67 (4): 637–43. doi:10.1212/01.wnl.0000230159.67128.00. PMID 16924018. Unknown parameter
|month=ignored (help)