Hairy cell leukemia differential diagnosis: Difference between revisions
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{{CMG}} {{AE}}{{HL}} | {{CMG}} {{AE}}{{HL}} | ||
==Overview== | ==Overview== | ||
* Hairy cell leukemia must be differentiated from other diseases that cause [[weight loss]], [[fatigue]], [[splenomegaly]], and fever, such as [[chronic lymphocytic leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]]. | * Hairy cell leukemia must be differentiated from other diseases that cause [[weight loss]], [[fatigue]], [[splenomegaly]], and fever, such as [[chronic lymphocytic leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]]. | ||
==Differenting Hairy cell leukemia from other Diseases== | ==Differenting Hairy cell leukemia from other Diseases== | ||
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! style="background: #4479BA; width: 600px;" | {{fontcolor|#FFF|'''Differential Diagnosis'''}} | ! style="background: #4479BA; width: 600px;" | {{fontcolor|#FFF|'''Differential Diagnosis'''}} | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
'''Hairy cell leukaemia''' | '''Hairy cell leukaemia''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Strongly positive''' | '''Strongly positive''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Negative''' | '''Negative''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Positive''' | '''Positive''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Negative''' | '''Negative''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Positive/Negative''' | '''Positive/Negative''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Positive''' | '''Positive''' | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
'''Chronic lymphocytic leukaemia''' | '''Chronic lymphocytic leukaemia''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center | | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Weakly positive''' | '''Weakly positive''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center | | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Positive''' | '''Positive''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center | | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Negative''' | '''Negative''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Positive''' | '''Positive''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Negative''' | '''Negative''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Positive/Negative''' | '''Positive/Negative''' | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
'''Prolymphocytic leukaemia''' | '''Prolymphocytic leukaemia''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Strongly positive''' | '''Strongly positive''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Negative''' | '''Negative''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Positive''' | '''Positive''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Negative''' | '''Negative''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Positive''' | '''Positive''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Negative''' | '''Negative''' | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
'''Mantle cell lymphoma''' | '''Mantle cell lymphoma''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Positive''' | '''Positive''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Positive''' | '''Positive''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Strongly positive''' | '''Strongly positive''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Negative''' | '''Negative''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Strongly positive''' | '''Strongly positive''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Negative''' | '''Negative''' | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
'''Follicular lymphoma''' | '''Follicular lymphoma''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Strongly positive''' | '''Strongly positive''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Negative''' | '''Negative''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Positive''' | '''Positive''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Negative''' | '''Negative''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Strongly positive''' | '''Strongly positive''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" align=center| | | style="padding: 5px 5px; background: #F5F5F5;" align="center" | | ||
'''Negative''' | '''Negative''' | ||
|} | |} |
Revision as of 01:23, 28 October 2018
Hairy cell leukemia Microchapters |
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Hairy cell leukemia differential diagnosis On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
- Hairy cell leukemia must be differentiated from other diseases that cause weight loss, fatigue, splenomegaly, and fever, such as chronic lymphocytic leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.
Differenting Hairy cell leukemia from other Diseases
- Hairy cell leukemia must be differentiated from other diseases that cause weight loss, fatigue, splenomegaly, and fever, such as chronic lymphocytic leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.[1]
Differential Diagnosis | Surface Immunoglobulin | CD5 | CD22/FMC7 | CD23 | CD79b | CD103 |
---|---|---|---|---|---|---|
Hairy cell leukaemia |
Strongly positive |
Negative |
Positive |
Negative |
Positive/Negative |
Positive |
Chronic lymphocytic leukaemia |
Weakly positive |
Positive |
Negative |
Positive |
Negative |
Positive/Negative |
Prolymphocytic leukaemia |
Strongly positive |
Negative |
Positive |
Negative |
Positive |
Negative |
Mantle cell lymphoma |
Positive |
Positive |
Strongly positive |
Negative |
Strongly positive |
Negative |
Follicular lymphoma |
Strongly positive |
Negative |
Positive |
Negative |
Strongly positive |
Negative |
- Hairy cell leukemia must also be differentiated from other causes of fever, splenomegaly, and fatigue such as:[2]
- Aplastic anemia
- Myelodysplastic syndrome
- Splenic marginal zone lymphoma
- B-cell prolymphocytic leukemia
- Idiopathic myelofibrosis
References
- ↑ Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011
- ↑ Hairy Cell Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Pathophysiology Accessed on October ,21 2015