Creutzfeldt-Jakob disease MRI: Difference between revisions
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==Overview== | ==Overview== | ||
MRI findings in CJD include high signal abnormalities in [[caudate nucleus]] and/or [[putamen]] on diffusion-weighted imaging (DWI) or fluid attenuated inversion recovery (FLAIR).<ref name="www.cdc.gov">{{Cite web | last = | first = | title = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | url = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | publisher = | date = | accessdate = 17 February 2014 }}</ref> Additional findings on diffusion weighted imaging include cortical, subcortical, and thalamic involvement. An abnormal signal in the poster thalami on T2 (pulvinar sign) and diffusion weighted images and fluid-attenuated inversion recovery sequences on brain MRI, in the appropriate clinical context, is highly specific for variant Creutzfeldt-Jakob disease. | MRI findings in CJD include high signal abnormalities in [[caudate nucleus]] and/or [[putamen]] on diffusion-weighted imaging (DWI) or fluid attenuated inversion recovery (FLAIR).<ref name="www.cdc.gov">{{Cite web | last = | first = | title = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | url = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | publisher = | date = | accessdate = 17 February 2014 }}</ref> Additional findings on diffusion weighted imaging include cortical, subcortical, and thalamic involvement. An abnormal signal in the poster thalami on T2 (pulvinar sign) and diffusion weighted images and fluid-attenuated inversion recovery sequences on brain MRI, in the appropriate clinical context, is highly specific for [[variant Creutzfeldt-Jakob disease]]. | ||
== MRI== | == MRI== | ||
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:*Cortical hyperintensity (25%-70% of cases) | :*Cortical hyperintensity (25%-70% of cases) | ||
:*Subcortical abnormalities (5% of cases) | :*Subcortical abnormalities (5% of cases) | ||
:*Thalamic involvement, usually in posterior thalamus (more strongly associated with variant Creutzfeldt-Jakob disease than with classic Creutzfeldt-Jakob disease)<ref>{{cite journal | last =Tschampa | first =Henriette J. |authorlink = | coauthors =Petra Mürtz, Sebastian Flacke, Sebastian Paus, Hans H. Schild and Horst Urbach | title =Thalamic Involvement in Sporadic Creutzfeldt-Jakob Disease: A Diffusion-Weighted MR Imaging Study | journal =American Journal of Neuroradiology | volume =24 | pages =908-915 | publisher =American Society of Neuroradiology |date=May 2003 | url =http://www.ajnr.org/cgi/content/full/24/5/908 | accessdate = 2007-10-30}}</ref> | :*Thalamic involvement, usually in posterior thalamus (more strongly associated with [[variant Creutzfeldt-Jakob disease]] than with classic Creutzfeldt-Jakob disease)<ref>{{cite journal | last =Tschampa | first =Henriette J. |authorlink = | coauthors =Petra Mürtz, Sebastian Flacke, Sebastian Paus, Hans H. Schild and Horst Urbach | title =Thalamic Involvement in Sporadic Creutzfeldt-Jakob Disease: A Diffusion-Weighted MR Imaging Study | journal =American Journal of Neuroradiology | volume =24 | pages =908-915 | publisher =American Society of Neuroradiology |date=May 2003 | url =http://www.ajnr.org/cgi/content/full/24/5/908 | accessdate = 2007-10-30}}</ref> | ||
*An abnormal signal in the poster thalami on T2 (pulvinar sign) and diffusion weighted images and fluid-attenuated inversion recovery sequences on brain MRI, in the appropriate clinical context, is highly specific for variant Creutzfeldt-Jakob disease. | *An abnormal signal in the poster thalami on T2 (pulvinar sign) and diffusion weighted images and fluid-attenuated inversion recovery sequences on brain MRI, in the appropriate clinical context, is highly specific for variant Creutzfeldt-Jakob disease. | ||
==References== | ==References== | ||
Revision as of 05:00, 30 October 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
MRI findings in CJD include high signal abnormalities in caudate nucleus and/or putamen on diffusion-weighted imaging (DWI) or fluid attenuated inversion recovery (FLAIR).[1] Additional findings on diffusion weighted imaging include cortical, subcortical, and thalamic involvement. An abnormal signal in the poster thalami on T2 (pulvinar sign) and diffusion weighted images and fluid-attenuated inversion recovery sequences on brain MRI, in the appropriate clinical context, is highly specific for variant Creutzfeldt-Jakob disease.
MRI
- MRI often shows high signal intensity in the caudate nucleus and putamen bilaterally on T2-weighted images.
- Diffusion Weighted Imaging (DWI) images may be remarkable for the following findings:[2]
- Cortical hyperintensity (25%-70% of cases)
- Subcortical abnormalities (5% of cases)
- Thalamic involvement, usually in posterior thalamus (more strongly associated with variant Creutzfeldt-Jakob disease than with classic Creutzfeldt-Jakob disease)[3]
- An abnormal signal in the poster thalami on T2 (pulvinar sign) and diffusion weighted images and fluid-attenuated inversion recovery sequences on brain MRI, in the appropriate clinical context, is highly specific for variant Creutzfeldt-Jakob disease.
References
- ↑ "http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html". Retrieved 17 February 2014. External link in
|title=(help) - ↑ Young, Geoffrey S. (June–July 2005). "Diffusion-Weighted and Fluid-Attenuated Inversion Recovery Imaging in Creutzfeldt-Jakob Disease: High Sensitivity and Specificity for Diagnosis". American Journal of Neuroradiology. American Society of Neuroradiology. 26: 1551–1562. Retrieved 2007-10-30. Unknown parameter
|coauthors=ignored (help) - ↑ Tschampa, Henriette J. (May 2003). "Thalamic Involvement in Sporadic Creutzfeldt-Jakob Disease: A Diffusion-Weighted MR Imaging Study". American Journal of Neuroradiology. American Society of Neuroradiology. 24: 908–915. Retrieved 2007-10-30. Unknown parameter
|coauthors=ignored (help)