Mantle cell lymphoma causes: Difference between revisions
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==Overview== | ==Overview== | ||
The cause of mantle cell lymphoma has not been identified. | The exact cause of mantle cell lymphoma has not been clearly identified. | ||
==Causes== | ==Causes== | ||
Mantle cell lymphoma, like most [[malignancies]], results from the acquisition of a combination of (non-inherited) genetic mutations in [[somatic cells]]. The factors that initiate the genetic alterations are typically not identifiable, and usually occur in people with no particular risk factors for lymphoma development. | Mantle cell lymphoma, like most [[malignancies]], results from the acquisition of a combination of (non-inherited) genetic mutations in [[somatic cells]]. The typical mutation occurring in mantle cell lymphoma causes the over expression of cyclin D1 which results in uncontrolled growth of B cells leading to lymphoma development. The factors that initiate the genetic alterations are typically not identifiable, and usually occur in people with no particular risk factors for lymphoma development. | ||
==References== | ==References== | ||
Revision as of 15:48, 8 November 2018
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Mantle cell lymphoma Microchapters |
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Mantle cell lymphoma causes On the Web |
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Risk calculators and risk factors for Mantle cell lymphoma causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
The exact cause of mantle cell lymphoma has not been clearly identified.
Causes
Mantle cell lymphoma, like most malignancies, results from the acquisition of a combination of (non-inherited) genetic mutations in somatic cells. The typical mutation occurring in mantle cell lymphoma causes the over expression of cyclin D1 which results in uncontrolled growth of B cells leading to lymphoma development. The factors that initiate the genetic alterations are typically not identifiable, and usually occur in people with no particular risk factors for lymphoma development.