Hairy cell leukemia laboratory tests: Difference between revisions
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===Complete Blood Count=== | ===Complete Blood Count=== | ||
* Decreased [[hemoglobin]] concentration<ref name="pub">{{cite journal |vauthors=Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R |title=Hairy cell leukemia: A decade long experience of North Indian Hematology Center |journal=Indian J Med Paediatr Oncol |volume=35 |issue=4 |pages=271–5 |year=2014 |pmid=25538404 |pmc=4264273 |doi=10.4103/0971-5851.144988 |url=}}</ref> | * Anemia - Decreased [[hemoglobin]] concentration<ref name="pub">{{cite journal |vauthors=Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R |title=Hairy cell leukemia: A decade long experience of North Indian Hematology Center |journal=Indian J Med Paediatr Oncol |volume=35 |issue=4 |pages=271–5 |year=2014 |pmid=25538404 |pmc=4264273 |doi=10.4103/0971-5851.144988 |url=}}</ref> | ||
* Decreased [[platelets]] count | * Thrombocytopenia - Decreased [[platelets]] count | ||
* Decreased [[WBC]] count | * Decreased [[WBC]] count | ||
* Neutropenia | |||
* Elevated BUN(Blood urea nitrogen) | |||
* Abnormal liver function tests | |||
* Hypergammaglobulinemia may be positive in small percentage of patients with [[hairy cell leukemia]] | |||
* Leukocytosis | |||
===Blood Smear=== | ===Blood Smear=== | ||
Revision as of 17:17, 16 November 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Laboratory findings consistent with the diagnosis of hairy cell leukemia include abnormal complete blood count, immunohistochemistry, and flow cytometry. The presence of hairy cells with thread-like cytoplasmic extensions on blood smear is a key diagnostic feature among patients with hairy cell leukemia.
Laboratory Findings
Laboratory findings consistent with the diagnosis of hairy cell leukemia include:
Complete Blood Count
- Anemia - Decreased hemoglobin concentration[1]
- Thrombocytopenia - Decreased platelets count
- Decreased WBC count
- Neutropenia
- Elevated BUN(Blood urea nitrogen)
- Abnormal liver function tests
- Hypergammaglobulinemia may be positive in small percentage of patients with hairy cell leukemia
- Leukocytosis
Blood Smear
- Hairy cells with thread-like cytoplasmic extensions[1]
- Positive TRAP stain
Immunohistochemistry
- On immunohistochemistry, characteristic findings of hairy cell leukemia include:[1]
- Annexin A1 +ve
- CD20 +ve
- CD25 +ve
- CD103 +ve
Flow Cytometry
- On flow cytometry, characteristic findings of hairy cell leukemia include:[1]
References
- ↑ 1.0 1.1 1.2 1.3 Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R (2014). "Hairy cell leukemia: A decade long experience of North Indian Hematology Center". Indian J Med Paediatr Oncol. 35 (4): 271–5. doi:10.4103/0971-5851.144988. PMC 4264273. PMID 25538404.