Hairy cell leukemia laboratory tests: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
Laboratory findings consistent with the diagnosis of [[hairy cell leukemia]] include:<ref name="pmid7519510">{{cite journal |vauthors=Frassoldati A, Lamparelli T, Federico M, Annino L, Capnist G, Pagnucco G, Dini E, Resegotti L, Damasio EE, Silingardi V |title=Hairy cell leukemia: a clinical review based on 725 cases of the Italian Cooperative Group (ICGHCL). Italian Cooperative Group for Hairy Cell Leukemia |journal=Leuk. Lymphoma |volume=13 |issue=3-4 |pages=307–16 |date=April 1994 |pmid=7519510 |doi=10.3109/10428199409056295 |url=}}</ref> | Laboratory findings consistent with the diagnosis of [[hairy cell leukemia]] include:<ref name="pmid7519510">{{cite journal |vauthors=Frassoldati A, Lamparelli T, Federico M, Annino L, Capnist G, Pagnucco G, Dini E, Resegotti L, Damasio EE, Silingardi V |title=Hairy cell leukemia: a clinical review based on 725 cases of the Italian Cooperative Group (ICGHCL). Italian Cooperative Group for Hairy Cell Leukemia |journal=Leuk. Lymphoma |volume=13 |issue=3-4 |pages=307–16 |date=April 1994 |pmid=7519510 |doi=10.3109/10428199409056295 |url=}}</ref><ref name="pmid717940">{{cite journal |vauthors=Golomb HM, Catovsky D, Golde DW |title=Hairy cell leukemia: a clinical review based on 71 cases |journal=Ann. Intern. Med. |volume=89 |issue=5 Pt 1 |pages=677–83 |date=November 1978 |pmid=717940 |doi= |url=}}</ref> | ||
=== Complete Blood Count === | === Complete Blood Count === | ||
Revision as of 17:26, 16 November 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Laboratory findings consistent with the diagnosis of hairy cell leukemia include abnormal complete blood count, immunohistochemistry, and flow cytometry. The presence of hairy cells with thread-like cytoplasmic extensions on blood smear is a key diagnostic feature among patients with hairy cell leukemia.
Laboratory Findings
Laboratory findings consistent with the diagnosis of hairy cell leukemia include:[1][2]
Complete Blood Count
- Anemia - Decreased hemoglobin concentration[3]
- Thrombocytopenia - Decreased platelets count
- Decreased WBC count
- Neutropenia
- Elevated BUN(Blood urea nitrogen)
- Abnormal liver function tests
- Hypergammaglobulinemia may be positive in small percentage of patients with hairy cell leukemia
- Leukocytosis
- Monocytopenia
Blood Smear
- Hairy cells with thread-like cytoplasmic extensions[3]
- Positive TRAP stain
Immunohistochemistry
- On immunohistochemistry, characteristic findings of hairy cell leukemia include:[3]
- Annexin A1 +ve
- CD20 +ve
- CD25 +ve
- CD103 +ve
Flow Cytometry
- On flow cytometry, characteristic findings of hairy cell leukemia include:[3]
References
- ↑ Frassoldati A, Lamparelli T, Federico M, Annino L, Capnist G, Pagnucco G, Dini E, Resegotti L, Damasio EE, Silingardi V (April 1994). "Hairy cell leukemia: a clinical review based on 725 cases of the Italian Cooperative Group (ICGHCL). Italian Cooperative Group for Hairy Cell Leukemia". Leuk. Lymphoma. 13 (3–4): 307–16. doi:10.3109/10428199409056295. PMID 7519510.
- ↑ Golomb HM, Catovsky D, Golde DW (November 1978). "Hairy cell leukemia: a clinical review based on 71 cases". Ann. Intern. Med. 89 (5 Pt 1): 677–83. PMID 717940.
- ↑ 3.0 3.1 3.2 3.3 Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R (2014). "Hairy cell leukemia: A decade long experience of North Indian Hematology Center". Indian J Med Paediatr Oncol. 35 (4): 271–5. doi:10.4103/0971-5851.144988. PMC 4264273. PMID 25538404.