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===Blood Smear===
===Blood Smear===
* Hairy cells with thread-like [[cytoplasmic]] extensions<ref name="GreverAbdel-Wahab20173">{{cite journal|last1=Grever|first1=Michael R.|last2=Abdel-Wahab|first2=Omar|last3=Andritsos|first3=Leslie A.|last4=Banerji|first4=Versha|last5=Barrientos|first5=Jacqueline|last6=Blachly|first6=James S.|last7=Call|first7=Timothy G.|last8=Catovsky|first8=Daniel|last9=Dearden|first9=Claire|last10=Demeter|first10=Judit|last11=Else|first11=Monica|last12=Forconi|first12=Francesco|last13=Gozzetti|first13=Alessandro|last14=Ho|first14=Anthony D.|last15=Johnston|first15=James B.|last16=Jones|first16=Jeffrey|last17=Juliusson|first17=Gunnar|last18=Kraut|first18=Eric|last19=Kreitman|first19=Robert J.|last20=Larratt|first20=Loree|last21=Lauria|first21=Francesco|last22=Lozanski|first22=Gerard|last23=Montserrat|first23=Emili|last24=Parikh|first24=Sameer A.|last25=Park|first25=Jae H.|last26=Polliack|first26=Aaron|last27=Quest|first27=Graeme R.|last28=Rai|first28=Kanti R.|last29=Ravandi|first29=Farhad|last30=Robak|first30=Tadeusz|last31=Saven|first31=Alan|last32=Seymour|first32=John F.|last33=Tadmor|first33=Tamar|last34=Tallman|first34=Martin S.|last35=Tam|first35=Constantine|last36=Tiacci|first36=Enrico|last37=Troussard|first37=Xavier|last38=Zent|first38=Clive S.|last39=Zenz|first39=Thorsten|last40=Zinzani|first40=Pier Luigi|last41=Falini|first41=Brunangelo|title=Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia|journal=Blood|volume=129|issue=5|year=2017|pages=553–560|issn=0006-4971|doi=10.1182/blood-2016-01-689422}}</ref><ref name="pmid356959">{{cite journal |vauthors=Golomb HM |title=Hairy cell leukemia: an unusual lymphoproliferative disease: a study of 24 patients |journal=Cancer |volume=42 |issue=2 Suppl |pages=946–56 |date=August 1978 |pmid=356959 |doi= |url=}}</ref>
* Hairy cells with thread-like [[cytoplasmic]] extensions<ref name="GreverAbdel-Wahab20173">{{cite journal|last1=Grever|first1=Michael R.|last2=Abdel-Wahab|first2=Omar|last3=Andritsos|first3=Leslie A.|last4=Banerji|first4=Versha|last5=Barrientos|first5=Jacqueline|last6=Blachly|first6=James S.|last7=Call|first7=Timothy G.|last8=Catovsky|first8=Daniel|last9=Dearden|first9=Claire|last10=Demeter|first10=Judit|last11=Else|first11=Monica|last12=Forconi|first12=Francesco|last13=Gozzetti|first13=Alessandro|last14=Ho|first14=Anthony D.|last15=Johnston|first15=James B.|last16=Jones|first16=Jeffrey|last17=Juliusson|first17=Gunnar|last18=Kraut|first18=Eric|last19=Kreitman|first19=Robert J.|last20=Larratt|first20=Loree|last21=Lauria|first21=Francesco|last22=Lozanski|first22=Gerard|last23=Montserrat|first23=Emili|last24=Parikh|first24=Sameer A.|last25=Park|first25=Jae H.|last26=Polliack|first26=Aaron|last27=Quest|first27=Graeme R.|last28=Rai|first28=Kanti R.|last29=Ravandi|first29=Farhad|last30=Robak|first30=Tadeusz|last31=Saven|first31=Alan|last32=Seymour|first32=John F.|last33=Tadmor|first33=Tamar|last34=Tallman|first34=Martin S.|last35=Tam|first35=Constantine|last36=Tiacci|first36=Enrico|last37=Troussard|first37=Xavier|last38=Zent|first38=Clive S.|last39=Zenz|first39=Thorsten|last40=Zinzani|first40=Pier Luigi|last41=Falini|first41=Brunangelo|title=Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia|journal=Blood|volume=129|issue=5|year=2017|pages=553–560|issn=0006-4971|doi=10.1182/blood-2016-01-689422}}</ref><ref name="pmid356959">{{cite journal |vauthors=Golomb HM |title=Hairy cell leukemia: an unusual lymphoproliferative disease: a study of 24 patients |journal=Cancer |volume=42 |issue=2 Suppl |pages=946–56 |date=August 1978 |pmid=356959 |doi= |url=}}</ref>
* Positive TRAP stain
* Positive TRAP stain<ref name="pmid6270794">{{cite journal |vauthors=Bernadou A, Pelletier G, Cadiou M, Giannoni F, James JM, Bilski-Pasquier G |title=[Hairy cell leukemia. I.--Clinical, biological and evolutive study on twenty-eight cases (author's transl)] |language=French |journal=Sem Hop |volume=57 |issue=33-36 |pages=1361–5 |date=1981 |pmid=6270794 |doi= |url=}}</ref>


===Immunohistochemistry===
===Immunohistochemistry===

Revision as of 17:37, 16 November 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Laboratory findings consistent with the diagnosis of hairy cell leukemia include abnormal complete blood count, immunohistochemistry, and flow cytometry. The presence of hairy cells with thread-like cytoplasmic extensions on blood smear is a key diagnostic feature among patients with hairy cell leukemia.

Laboratory Findings

Laboratory findings consistent with the diagnosis of hairy cell leukemia include:[1][2][3][4][5]

Complete Blood Count

Blood Smear

Immunohistochemistry

  • On immunohistochemistry, characteristic findings of hairy cell leukemia include:[10]

Flow Cytometry

  • On flow cytometry, characteristic findings of hairy cell leukemia include:[11]

References

  1. ↑ Grever, Michael R.; Abdel-Wahab, Omar; Andritsos, Leslie A.; Banerji, Versha; Barrientos, Jacqueline; Blachly, James S.; Call, Timothy G.; Catovsky, Daniel; Dearden, Claire; Demeter, Judit; Else, Monica; Forconi, Francesco; Gozzetti, Alessandro; Ho, Anthony D.; Johnston, James B.; Jones, Jeffrey; Juliusson, Gunnar; Kraut, Eric; Kreitman, Robert J.; Larratt, Loree; Lauria, Francesco; Lozanski, Gerard; Montserrat, Emili; Parikh, Sameer A.; Park, Jae H.; Polliack, Aaron; Quest, Graeme R.; Rai, Kanti R.; Ravandi, Farhad; Robak, Tadeusz; Saven, Alan; Seymour, John F.; Tadmor, Tamar; Tallman, Martin S.; Tam, Constantine; Tiacci, Enrico; Troussard, Xavier; Zent, Clive S.; Zenz, Thorsten; Zinzani, Pier Luigi; Falini, Brunangelo (2017). "Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia". Blood. 129 (5): 553–560. doi:10.1182/blood-2016-01-689422. ISSN 0006-4971.
  2. ↑ Frassoldati A, Lamparelli T, Federico M, Annino L, Capnist G, Pagnucco G, Dini E, Resegotti L, Damasio EE, Silingardi V (April 1994). "Hairy cell leukemia: a clinical review based on 725 cases of the Italian Cooperative Group (ICGHCL). Italian Cooperative Group for Hairy Cell Leukemia". Leuk. Lymphoma. 13 (3–4): 307–16. doi:10.3109/10428199409056295. PMID 7519510.
  3. ↑ Golomb HM, Catovsky D, Golde DW (November 1978). "Hairy cell leukemia: a clinical review based on 71 cases". Ann. Intern. Med. 89 (5 Pt 1): 677–83. PMID 717940.
  4. ↑ Kraut E (June 2011). "Infectious complications in hairy cell leukemia". Leuk. Lymphoma. 52 Suppl 2: 50–2. doi:10.3109/10428194.2011.570819. PMID 21504285.
  5. ↑ Westbrook CA, Groopman JE, Golde DW (August 1984). "Hairy cell leukemia. Disease pattern and prognosis". Cancer. 54 (3): 500–6. PMID 6733679.
  6. ↑ Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R (2014). "Hairy cell leukemia: A decade long experience of North Indian Hematology Center". Indian J Med Paediatr Oncol. 35 (4): 271–5. doi:10.4103/0971-5851.144988. PMC 4264273. PMID 25538404.
  7. ↑ Grever, Michael R.; Abdel-Wahab, Omar; Andritsos, Leslie A.; Banerji, Versha; Barrientos, Jacqueline; Blachly, James S.; Call, Timothy G.; Catovsky, Daniel; Dearden, Claire; Demeter, Judit; Else, Monica; Forconi, Francesco; Gozzetti, Alessandro; Ho, Anthony D.; Johnston, James B.; Jones, Jeffrey; Juliusson, Gunnar; Kraut, Eric; Kreitman, Robert J.; Larratt, Loree; Lauria, Francesco; Lozanski, Gerard; Montserrat, Emili; Parikh, Sameer A.; Park, Jae H.; Polliack, Aaron; Quest, Graeme R.; Rai, Kanti R.; Ravandi, Farhad; Robak, Tadeusz; Saven, Alan; Seymour, John F.; Tadmor, Tamar; Tallman, Martin S.; Tam, Constantine; Tiacci, Enrico; Troussard, Xavier; Zent, Clive S.; Zenz, Thorsten; Zinzani, Pier Luigi; Falini, Brunangelo (2017). "Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia". Blood. 129 (5): 553–560. doi:10.1182/blood-2016-01-689422. ISSN 0006-4971.
  8. ↑ Golomb HM (August 1978). "Hairy cell leukemia: an unusual lymphoproliferative disease: a study of 24 patients". Cancer. 42 (2 Suppl): 946–56. PMID 356959.
  9. ↑ Bernadou A, Pelletier G, Cadiou M, Giannoni F, James JM, Bilski-Pasquier G (1981). "[Hairy cell leukemia. I.--Clinical, biological and evolutive study on twenty-eight cases (author's transl)]". Sem Hop (in French). 57 (33–36): 1361–5. PMID 6270794.
  10. ↑ Grever, Michael R.; Abdel-Wahab, Omar; Andritsos, Leslie A.; Banerji, Versha; Barrientos, Jacqueline; Blachly, James S.; Call, Timothy G.; Catovsky, Daniel; Dearden, Claire; Demeter, Judit; Else, Monica; Forconi, Francesco; Gozzetti, Alessandro; Ho, Anthony D.; Johnston, James B.; Jones, Jeffrey; Juliusson, Gunnar; Kraut, Eric; Kreitman, Robert J.; Larratt, Loree; Lauria, Francesco; Lozanski, Gerard; Montserrat, Emili; Parikh, Sameer A.; Park, Jae H.; Polliack, Aaron; Quest, Graeme R.; Rai, Kanti R.; Ravandi, Farhad; Robak, Tadeusz; Saven, Alan; Seymour, John F.; Tadmor, Tamar; Tallman, Martin S.; Tam, Constantine; Tiacci, Enrico; Troussard, Xavier; Zent, Clive S.; Zenz, Thorsten; Zinzani, Pier Luigi; Falini, Brunangelo (2017). "Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia". Blood. 129 (5): 553–560. doi:10.1182/blood-2016-01-689422. ISSN 0006-4971.
  11. ↑ Grever, Michael R.; Abdel-Wahab, Omar; Andritsos, Leslie A.; Banerji, Versha; Barrientos, Jacqueline; Blachly, James S.; Call, Timothy G.; Catovsky, Daniel; Dearden, Claire; Demeter, Judit; Else, Monica; Forconi, Francesco; Gozzetti, Alessandro; Ho, Anthony D.; Johnston, James B.; Jones, Jeffrey; Juliusson, Gunnar; Kraut, Eric; Kreitman, Robert J.; Larratt, Loree; Lauria, Francesco; Lozanski, Gerard; Montserrat, Emili; Parikh, Sameer A.; Park, Jae H.; Polliack, Aaron; Quest, Graeme R.; Rai, Kanti R.; Ravandi, Farhad; Robak, Tadeusz; Saven, Alan; Seymour, John F.; Tadmor, Tamar; Tallman, Martin S.; Tam, Constantine; Tiacci, Enrico; Troussard, Xavier; Zent, Clive S.; Zenz, Thorsten; Zinzani, Pier Luigi; Falini, Brunangelo (2017). "Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia". Blood. 129 (5): 553–560. doi:10.1182/blood-2016-01-689422. ISSN 0006-4971.


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