Endometrial cancer classification: Difference between revisions

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==Classification==
==Classification==
Endometrial cancer may be classified according to histology into 2 types:
Endometrial cancer may be classified according to histology into 2 types:
* Type I
**
* Type II
{| class="wikitable"
{| class="wikitable"
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Type
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Type
Line 22: Line 18:
| style="background:#F5F5F5;" align="center" + |Endometroid (adenocarcinoma)
| style="background:#F5F5F5;" align="center" + |Endometroid (adenocarcinoma)
| style="background:#F5F5F5;" align="center" + |Favorable (estrogen-responsive)
| style="background:#F5F5F5;" align="center" + |Favorable (estrogen-responsive)
| style="background:#F5F5F5;" align="left" + |• May arise from atypical hyperplasia </br> • Linked to unopposed estrogen stimulation
| style="background:#F5F5F5;" align="left" + |• May arise from atypical hyperplasia <br> • Linked to unopposed estrogen stimulation
| style="background:#F5F5F5;" align="center" + |80%  
| style="background:#F5F5F5;" align="center" + |80%  
|-
|-
| style="background:#DCDCDC;" align="center" + |Type II
| style="background:#DCDCDC;" align="center" + |Type II
| style="background:#F5F5F5;" align="left" + |• Endometroid </br>• Serous </br>• Clear cell </br>• Mucinous </br>• Squamous </br>• Mesonephric </br>• Undifferentiated
| style="background:#F5F5F5;" align="left" + |• Endometroid <br>• Serous <br>• Clear cell <br>• Mucinous <br>• Squamous <br>• Mesonephric <br>• Undifferentiated
| style="background:#F5F5F5;" align="center" + |Typically bad prognosis
| style="background:#F5F5F5;" align="center" + |Typically bad prognosis
| style="background:#F5F5F5;" align="left" + |• Develops from atrophic endometrium </br>• Not linked to hormonally driven pathogenesis
| style="background:#F5F5F5;" align="left" + |• Develops from atrophic endometrium <br>• Not linked to hormonally driven pathogenesis
| style="background:#F5F5F5;" align="center" + |15-20%
| style="background:#F5F5F5;" align="center" + |15-20%
|}
|}
===Classification Based on Pathogenesis===
* Endometrial cancers are classified into either type 1 or type 2:<ref>{{Cite web | title = endometrial cancer classification | url =http://www.cancer.gov/types/uterine/hp/endometrial-treatment-pdq#section/_9 }}</ref>
:* Type 1 may arise from complex atypical [[hyperplasia]] and is pathogenetically linked to unopposed estrogenic stimulation.
:* Type 2 develops from atrophic [[endometrium]] and is not linked to hormonally driven pathogenesis.
===Classification Based on Histopathological Subtype===
There are 7 subtypes of endometrial cancer based on histopathology:
: 1. Endometrioid (75%–80%)(The most common endometrial cancer cell type is endometrioid adenocarcinoma, which is composed of malignant [[glandular]] epithelial elements)
::* Ciliated adenocarcinoma
::* Secretory adenocarcinoma
::* [[Papillary]] or villoglandular
::* Adenocarcinoma with squamous differentiation
:::* Adenoacanthoma
:::* Adenosquamous (Adenosquamous tumors contain malignant elements of both glandular and squamous epithelium)
: 2. Uterine papillary serous (<10%)
: 3. Mucinous (1%)
: 4. Clear cell (4%)
: 5. [[Squamous cell]] (<1%)
: 6. Mixed (10%)
: 7. Undifferentiated
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Revision as of 18:39, 26 November 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]

Overview

Endometrial cancer may be classified according to histology into either type I comprising 80% of endometrial cancers or type II accounting for around 20%.

Classification

Endometrial cancer may be classified according to histology into 2 types:

Type Histology Prognosis Pathogenesis Prevalence
Type I Endometroid (adenocarcinoma) Favorable (estrogen-responsive) • May arise from atypical hyperplasia
• Linked to unopposed estrogen stimulation 		80%
Type II • Endometroid
• Serous
• Clear cell
• Mucinous
• Squamous
• Mesonephric
• Undifferentiated 		Typically bad prognosis • Develops from atrophic endometrium
• Not linked to hormonally driven pathogenesis 		15-20%

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