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| ==Medical Therapy== | | ==Medical Therapy== |
| {| class="wikitable"
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| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Risk
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| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Risk definition
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| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Management
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| ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Additional notes
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| |-
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| | style="background:#DCDCDC;" align="center" + |Low risk
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| | style="background:#F5F5F5;" align="center" + |• Stage IA endometrial cancer <br> • Well differentiated endometroid histology <br> • Tumor confined to endometrium
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| | style="background:#F5F5F5;" align="center" + |Total hysterectomy, bilateral salpingo-oophorectomy, and lymph node evaluation
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| | style="background:#F5F5F5;" align="center" + |• Women that opt for preservation of fertility may be candidates for medical therapy <br> • Adjuvant therapy not indicated
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| |-
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| | style="background:#DCDCDC;" align="center" + |Intermediate risk
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| | style="background:#F5F5F5;" align="center" + |• Stage I (tumor invades myometrium) or <br> • Stage II (tumor demonstrates cervical stroma invasion) <br> • Tumor usually moderately differentiated or poorly differentiated
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| | style="background:#F5F5F5;" align="center" + |• Total hysterectomy, bilateral salpingo-oophorecomy, and lymph node evaluation <br> • Adjuvant radiotherapy is indicated for patients with risk factors
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| | style="background:#F5F5F5;" align="center" + |• No data available to recommend adjuvant chemotherapy in these patients <br> • Observation recommended instead of adjuvant radiotherapy if patient has no risk factors
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| |-
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| | style="background:#DCDCDC;" align="center" + |High risk
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| | style="background:#F5F5F5;" align="center" + |• Stage III or higher or <br> • Any stage with serous or clear cell carcinoma
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| | style="background:#F5F5F5;" align="center" + |• For stage I and II, surgery may be followed by adjuvant vaginal brachytherapy <br> • For stage III and IV, surgery should be followed by adjuvant chemotherapy and pelvic radiotherapy
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| | style="background:#F5F5F5;" align="center" + |Giving adjuvant brachytherapy for the high risk early staged tumors depends on patient and provider preferences
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| |}
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| ==References== | | ==References== |