Endometrial cancer medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The optimal therapy for endometrial cancer depends on the stage at diagnosis. A combination of chemotherapy and radiation therapy is indicated in stages IIIB- IV.

Medical Therapy

• The optimal therapy for endometrial cancer depends on the stage at diagnosis. A combination of chemotherapy and radiation therapy is indicated in stages IIIB- IV.
• Chemotherapy is not the first-line treatment option for patients with stage I-III endometrial cancer. Surgery is the mainstay of treatment.

• Chemotherapy without prior surgery is usually reserved for patients with stage IV endometrial cancer or patients that are not surgical candidates.
  • Typically a platinum based combination regimen or triple druge therapy is used:
    • Carboplatin + paclitaxel
    • Cisplatin + doxorubicin + paclitaxel
  • Endocrine therapy is also used with favorable results in patients with:
    • Endometroid endmetrial cancer
    • Express estrogen and progesterone receptors
    • Asymptomatic disease

References

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