Mantle cell lymphoma diagnostic study of choice: Difference between revisions
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=== Study of choice === | === Study of choice === | ||
* Tissue biopsy (nodal or extranodal) is the gold standard test for the diagnosis of mantle cell lymphoma. | * '''Tissue biopsy''' (nodal or extranodal) is the gold standard test for the diagnosis of mantle cell lymphoma. | ||
==== Histology ==== | ==== Histology ==== | ||
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* SOX11 expression may be useful if cyclin D1 is negative. | * SOX11 expression may be useful if cyclin D1 is negative. | ||
==== Fluorescence in situ hybridization (FISH) ==== | |||
* FISH can be used to detect the translocation t(11;14), which is found in most of MCL patients. | |||
==== Karyotyping: ==== | |||
* Karyotyping can also be used to detect the translocation t(11;14), which is found in most of MCL patients. | |||
* | * | ||
Revision as of 21:00, 13 December 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2]
Overview
Diagnostic Study of Choice
Study of choice
- Tissue biopsy (nodal or extranodal) is the gold standard test for the diagnosis of mantle cell lymphoma.
Histology
- The microscopic histological findings can be found here.
Immunohistochemistry
- CD19, CD20, CD22, CD43, CD79a, CD5, and FMC7 typically are positive, whereas CD23, CD10, CD200, and BCL6 are usually negative.[1][2]
- Cyclin D1 is positive in majority of the cases.
- SOX11 expression may be useful if cyclin D1 is negative.
Fluorescence in situ hybridization (FISH)
- FISH can be used to detect the translocation t(11;14), which is found in most of MCL patients.
Karyotyping:
- Karyotyping can also be used to detect the translocation t(11;14), which is found in most of MCL patients.
References
- ↑ Francesco Bertoni, Emanuele Zucca & Finbarr E. Cotter (2004). "Molecular basis of mantle cell lymphoma". British journal of haematology. 124 (2): 130–140. PMID 14687022. Unknown parameter
|month=ignored (help) - ↑ Chan Yoon Cheah, John F. Seymour & Michael L. Wang (2016). "Mantle Cell Lymphoma". Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 34 (11): 1256–1269. doi:10.1200/JCO.2015.63.5904. PMID 26755518. Unknown parameter
|month=ignored (help)