Mantle cell lymphoma laboratory findings: Difference between revisions

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* Pregnancy testing in woman of child-bearing age
* Pregnancy testing in woman of child-bearing age
* [[Flow cytometry]]
* [[Flow cytometry]]
* Immunohistochemistry
* Immunohistochemistry<ref>{{Cite journal
| author = [[Francesco Bertoni]], [[Emanuele Zucca]] & [[Finbarr E. Cotter]]
| title = Molecular basis of mantle cell lymphoma
| journal = [[British journal of haematology]]
| volume = 124
| issue = 2
| pages = 130–140
| year = 2004
| month = January
| pmid = 14687022
}}</ref><ref>{{Cite journal
| author = [[Chan Yoon Cheah]], [[John F. Seymour]] & [[Michael L. Wang]]
| title = Mantle Cell Lymphoma
| journal = [[Journal of clinical oncology : official journal of the American Society of Clinical Oncology]]
| volume = 34
| issue = 11
| pages = 1256–1269
| year = 2016
| month = April
| doi = 10.1200/JCO.2015.63.5904
| pmid = 26755518
}}</ref>
:* CD19, CD20, CD22, CD43, CD79a, CD5, and FMC7 typically are positive, whereas CD23, CD10, CD200, and BCL6 are usually negative
:* CD19, CD20, CD22, CD43, CD79a, CD5, and FMC7 typically are positive, whereas CD23, CD10, CD200, and BCL6 are usually negative
:* Overexpression of CYCLIN D
:* Overexpression of CYCLIN D
:* SOX11 expression
:* SOX11 expression
* [[Genetic testing]]
* [[Genetic testing]]<ref>{{Cite journal
| author = [[Jordi Camps]], [[Itziar Salaverria]], [[Maria J. Garcia]], [[Esther Prat]], [[Silvia Bea]], [[Jessica C. Pole]], [[Lluis Hernandez]], [[Javier Del Rey]], [[Juan Cruz Cigudosa]], [[Marta Bernues]], [[Carlos Caldas]], [[Dolors Colomer]], [[Rosa Miro]] & [[Elias Campo]]
| title = Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines
| journal = [[Leukemia research]]
| volume = 30
| issue = 8
| pages = 923–934
| year = 2006
| month = August
| doi = 10.1016/j.leukres.2005.11.013
| pmid = 16448697
}}</ref>
:* Heavy and light chain genes rearranged, t(11;14)(q13;q32) in virtually all cases
:* Heavy and light chain genes rearranged, t(11;14)(q13;q32) in virtually all cases
:* Mutation or deletions of ''ATM gene''
:* Mutation or deletions of ''ATM gene''
* [[FISH]] (fluorescence in situ hybridization)
* [[FISH]] (fluorescence in situ hybridization)<ref>{{Cite journal
| author = [[Tsieh Sun]], [[Mary Lowery Nordberg]], [[James D. Cotelingam]], [[Diana M. Veillon]] & [[John Ryder]]
| title = Fluorescence in situ hybridization: method of choice for a definitive diagnosis of mantle cell lymphoma
| journal = [[American journal of hematology]]
| volume = 74
| issue = 1
| pages = 78–84
| year = 2003
| month = September
| doi = 10.1002/ajh.10356
| pmid = 12949897
}}</ref>
* [[PCR]]  
* [[PCR]]  
:*[[Polymerase chain reaction]] (PCR) and CER3 clonotypic primers are additional methods, but are less often used.
:*[[Polymerase chain reaction]] (PCR) and CER3 clonotypic primers are additional methods, but are less often used.

Revision as of 16:37, 18 December 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]

Overview

Laboratory tests for mantle cell lymphoma include complete blood count (CBC), comprehensive metabolic panel, LDH levels, Hepatitis B testing if treatment with rituximab is planned, uric acid levels, beta-2-microglobulin, pregnancy testing in woman of child-bearing age, flow cytometry, immunohistochemistry, genetic testing, FISH and PCR

Laboratory tests

Laboratory tests for mantle cell lymphoma include:

  • Complete blood count (CBC) with differential count
  • Comprehensive metabolic panel
  • LDH levels
  • Hepatitis B testing if treatment with rituximab is planned
  • Uric acid levels
  • Beta-2-microglobulin
  • Pregnancy testing in woman of child-bearing age
  • Flow cytometry
  • Immunohistochemistry[1][2]
  • CD19, CD20, CD22, CD43, CD79a, CD5, and FMC7 typically are positive, whereas CD23, CD10, CD200, and BCL6 are usually negative
  • Overexpression of CYCLIN D
  • SOX11 expression
  • Heavy and light chain genes rearranged, t(11;14)(q13;q32) in virtually all cases
  • Mutation or deletions of ATM gene


References

  1. ↑ Francesco Bertoni, Emanuele Zucca & Finbarr E. Cotter (2004). "Molecular basis of mantle cell lymphoma". British journal of haematology. 124 (2): 130–140. PMID 14687022. Unknown parameter |month= ignored (help)
  2. ↑ Chan Yoon Cheah, John F. Seymour & Michael L. Wang (2016). "Mantle Cell Lymphoma". Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 34 (11): 1256–1269. doi:10.1200/JCO.2015.63.5904. PMID 26755518. Unknown parameter |month= ignored (help)
  3. ↑ Jordi Camps, Itziar Salaverria, Maria J. Garcia, Esther Prat, Silvia Bea, Jessica C. Pole, Lluis Hernandez, Javier Del Rey, Juan Cruz Cigudosa, Marta Bernues, Carlos Caldas, Dolors Colomer, Rosa Miro & Elias Campo (2006). "Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines". Leukemia research. 30 (8): 923–934. doi:10.1016/j.leukres.2005.11.013. PMID 16448697. Unknown parameter |month= ignored (help)
  4. ↑ Tsieh Sun, Mary Lowery Nordberg, James D. Cotelingam, Diana M. Veillon & John Ryder (2003). "Fluorescence in situ hybridization: method of choice for a definitive diagnosis of mantle cell lymphoma". American journal of hematology. 74 (1): 78–84. doi:10.1002/ajh.10356. PMID 12949897. Unknown parameter |month= ignored (help)

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