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Laboratory tests for mantle cell lymphoma include [[complete blood count]] (CBC), comprehensive metabolic panel, LDH levels, Hepatitis B testing if treatment with rituximab is planned, uric acid levels, beta-2-microglobulin, pregnancy testing in woman of child-bearing age, [[flow cytometry]], [[immunohistochemistry]], [[genetic testing]], [[FISH]] and [[PCR]]  
Laboratory tests for mantle cell lymphoma include [[complete blood count]] (CBC), comprehensive metabolic panel, LDH levels, Hepatitis B testing if treatment with rituximab is planned, uric acid levels, beta-2-microglobulin, pregnancy testing in woman of child-bearing age, [[flow cytometry]], [[immunohistochemistry]], [[genetic testing]], [[FISH]] and [[PCR]]  
==Laboratory tests==
==Laboratory tests==
Laboratory tests for mantle cell lymphoma include:
Laboratory tests for mantle cell lymphoma include:https:<ref>//www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf</ref>
* [[Complete blood count]] (CBC) with differential count
* [[Complete blood count]] (CBC) with differential count
* Comprehensive metabolic panel
:* Pancytopenia or a leukemic presentation with extensive leukocytosis.<ref>{{Cite journal
* LDH levels
| author = [[Ana Ferrer]], [[Itziar Salaverria]], [[Francesc Bosch]], [[Neus Villamor]], [[Maria Rozman]], [[Silvia Bea]], [[Eva Gine]], [[Armando Lopez-Guillermo]], [[Elias Campo]] & [[Emili Montserrat]]
* Hepatitis B testing if treatment with rituximab is planned
| title = Leukemic involvement is a common feature in mantle cell lymphoma
| journal = [[Cancer]]
| volume = 109
| issue = 12
| pages = 2473–2480
| year = 2007
| month = June
| doi = 10.1002/cncr.22715
| pmid = 17477385
}}</ref>
* Comprehensive metabolic panel<ref>{{Cite journal
| author = [[Julie M. Vose]]
| title = Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management
| journal = [[American journal of hematology]]
| volume = 92
| issue = 8
| pages = 806–813
| year = 2017
| month = August
| doi = 10.1002/ajh.24797
| pmid = 28699667
}}</ref>
* LDH levels<ref>{{Cite journal
| author = [[Julie M. Vose]]
| title = Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management
| journal = [[American journal of hematology]]
| volume = 92
| issue = 8
| pages = 806–813
| year = 2017
| month = August
| doi = 10.1002/ajh.24797
| pmid = 28699667
}}</ref>
* Hepatitis B testing if treatment with rituximab is planned<ref>{{Cite journal
| author = [[Arturo Ciccullo]], [[F. R. Ponziani]], [[E. Maiolo]], [[F. Pallavicini]] & [[M. Pompili]]
| title = Late reactivation of hepatitis B virus after rituximab-containing chemotherapy for mantle cell lymphoma: a case report
| journal = [[Infection]]
| year = 2018
| month = October
| doi = 10.1007/s15010-018-1242-1
| pmid = 30368733
}}</ref>
* Uric acid levels
* Uric acid levels
* Beta-2-microglobulin
* Beta-2-microglobulin<ref>{{Cite journal
| author = [[Julie M. Vose]]
| title = Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management
| journal = [[American journal of hematology]]
| volume = 92
| issue = 8
| pages = 806–813
| year = 2017
| month = August
| doi = 10.1002/ajh.24797
| pmid = 28699667
}}</ref>
* Pregnancy testing in woman of child-bearing age
* Pregnancy testing in woman of child-bearing age
* [[Flow cytometry]]
* [[Flow cytometry]]
Line 66: Line 119:
  | pmid = 12949897
  | pmid = 12949897
}}</ref>
}}</ref>
* [[PCR]]  
* [[PCR]]<ref>{{Cite journal
| author = [[Francesco Bertoni]] & [[Maurilio Ponzoni]]
| title = The cellular origin of mantle cell lymphoma
| journal = [[The international journal of biochemistry & cell biology]]
| volume = 39
| issue = 10
| pages = 1747–1753
| year = 2007
| month =
| doi = 10.1016/j.biocel.2007.04.026
| pmid = 17574898
}}</ref>
:*[[Polymerase chain reaction]] (PCR) and CER3 clonotypic primers are additional methods, but are less often used.
:*[[Polymerase chain reaction]] (PCR) and CER3 clonotypic primers are additional methods, but are less often used.


Revision as of 16:53, 18 December 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]

Overview

Laboratory tests for mantle cell lymphoma include complete blood count (CBC), comprehensive metabolic panel, LDH levels, Hepatitis B testing if treatment with rituximab is planned, uric acid levels, beta-2-microglobulin, pregnancy testing in woman of child-bearing age, flow cytometry, immunohistochemistry, genetic testing, FISH and PCR

Laboratory tests

Laboratory tests for mantle cell lymphoma include:https:[1]

  • Pancytopenia or a leukemic presentation with extensive leukocytosis.[2]
  • Comprehensive metabolic panel[3]
  • LDH levels[4]
  • Hepatitis B testing if treatment with rituximab is planned[5]
  • Uric acid levels
  • Beta-2-microglobulin[6]
  • Pregnancy testing in woman of child-bearing age
  • Flow cytometry
  • Immunohistochemistry[7][8]
  • CD19, CD20, CD22, CD43, CD79a, CD5, and FMC7 typically are positive, whereas CD23, CD10, CD200, and BCL6 are usually negative
  • Overexpression of CYCLIN D
  • SOX11 expression
  • Heavy and light chain genes rearranged, t(11;14)(q13;q32) in virtually all cases
  • Mutation or deletions of ATM gene


References

  1. ↑ //www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf
  2. ↑ Ana Ferrer, Itziar Salaverria, Francesc Bosch, Neus Villamor, Maria Rozman, Silvia Bea, Eva Gine, Armando Lopez-Guillermo, Elias Campo & Emili Montserrat (2007). "Leukemic involvement is a common feature in mantle cell lymphoma". Cancer. 109 (12): 2473–2480. doi:10.1002/cncr.22715. PMID 17477385. Unknown parameter |month= ignored (help)
  3. ↑ Julie M. Vose (2017). "Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management". American journal of hematology. 92 (8): 806–813. doi:10.1002/ajh.24797. PMID 28699667. Unknown parameter |month= ignored (help)
  4. ↑ Julie M. Vose (2017). "Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management". American journal of hematology. 92 (8): 806–813. doi:10.1002/ajh.24797. PMID 28699667. Unknown parameter |month= ignored (help)
  5. ↑ Arturo Ciccullo, F. R. Ponziani, E. Maiolo, F. Pallavicini & M. Pompili (2018). "Late reactivation of hepatitis B virus after rituximab-containing chemotherapy for mantle cell lymphoma: a case report". Infection. doi:10.1007/s15010-018-1242-1. PMID 30368733. Unknown parameter |month= ignored (help)
  6. ↑ Julie M. Vose (2017). "Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management". American journal of hematology. 92 (8): 806–813. doi:10.1002/ajh.24797. PMID 28699667. Unknown parameter |month= ignored (help)
  7. ↑ Francesco Bertoni, Emanuele Zucca & Finbarr E. Cotter (2004). "Molecular basis of mantle cell lymphoma". British journal of haematology. 124 (2): 130–140. PMID 14687022. Unknown parameter |month= ignored (help)
  8. ↑ Chan Yoon Cheah, John F. Seymour & Michael L. Wang (2016). "Mantle Cell Lymphoma". Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 34 (11): 1256–1269. doi:10.1200/JCO.2015.63.5904. PMID 26755518. Unknown parameter |month= ignored (help)
  9. ↑ Jordi Camps, Itziar Salaverria, Maria J. Garcia, Esther Prat, Silvia Bea, Jessica C. Pole, Lluis Hernandez, Javier Del Rey, Juan Cruz Cigudosa, Marta Bernues, Carlos Caldas, Dolors Colomer, Rosa Miro & Elias Campo (2006). "Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines". Leukemia research. 30 (8): 923–934. doi:10.1016/j.leukres.2005.11.013. PMID 16448697. Unknown parameter |month= ignored (help)
  10. ↑ Tsieh Sun, Mary Lowery Nordberg, James D. Cotelingam, Diana M. Veillon & John Ryder (2003). "Fluorescence in situ hybridization: method of choice for a definitive diagnosis of mantle cell lymphoma". American journal of hematology. 74 (1): 78–84. doi:10.1002/ajh.10356. PMID 12949897. Unknown parameter |month= ignored (help)
  11. ↑ Francesco Bertoni & Maurilio Ponzoni (2007). "The cellular origin of mantle cell lymphoma". The international journal of biochemistry & cell biology. 39 (10): 1747–1753. doi:10.1016/j.biocel.2007.04.026. PMID 17574898.

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