Hemophilia classification: Difference between revisions
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==Overview== | ==Overview== | ||
Hemophilia may be classified into three subtypes based on the lack of functional clotting factors: [[hemophilia A]] , [[hemophilia B]], [[hemophilia C]]. | Hemophilia may be classified into three subtypes based on the lack of functional clotting factors: [[hemophilia A]] , [[hemophilia B]], [[hemophilia C]]. It can also be divided into different categories based on the severity of the condition. Hemophilia can also be [[acquired]] in the setting of antibodies directed against the clotting factors. | ||
==Classification== | ==Classification== |
Revision as of 20:02, 26 December 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Hemophilia may be classified into three subtypes based on the lack of functional clotting factors: hemophilia A , hemophilia B, hemophilia C. It can also be divided into different categories based on the severity of the condition. Hemophilia can also be acquired in the setting of antibodies directed against the clotting factors.
Classification
- Hemophilia can be classified into:
1. Hemophilia A: A recessive X-linked genetic disorder involving a lack of functional clotting factor VIII and representing 80% of hemophilia cases.
2. Hemophilia B: A recessive X-linked genetic disorder involving a lack of functional clotting factor IX and comprising approximately 20% of hemophilia cases.
3. Hemophilia C: An autosomal genetic disorder involving a lack of functional clotting factor XI. This condition is not completely recessive, as heterozygous individuals also show increased bleeding.
Classification based on severity
- Hemophilia may be classified as severe, moderate or mild based on the levels of factor VIII or factor IX.[1]
Severity | Levels of Factor VIII (8)
or IX (9) in the blood |
---|---|
Normal (person who does not have hemophilia) | 50% to 100% |
Mild hemophilia | Greater than 5% but less than 50% |
Moderate hemophilia | 1% to 5% |
Severe hemophilia | Less than 1% |
Adapted from CDC Hemophilia Diagnosis> "CDC Hemophilia Diagnosis". |