Mantle cell lymphoma laboratory findings: Difference between revisions

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{{CMG}}; {{AE}} {{Akram}} {{AS}}
{{CMG}}; {{AE}} {{Akram}} {{AS}}
==Overview==
==Overview==
Laboratory tests for [[mantle cell lymphoma]] include [[complete blood count]] (CBC), [[comprehensive metabolic panel]], [[LDH]] levels, [[Hepatitis B/Laboratory Tests|Hepatitis B]] testing if treatment with [[rituximab]] is planned, [[uric acid]] levels, [[beta-2-microglobulin]], pregnancy testing in woman of child-bearing age, [[flow cytometry]], [[immunohistochemistry]], [[genetic testing]], [[FISH]] and [[PCR]]
Laboratory tests for mantle cell lymphoma include [[complete blood count]] (CBC), [[comprehensive metabolic panel]], [[LDH]] levels, [[Hepatitis B/Laboratory Tests|Hepatitis B]] testing if treatment with [[rituximab]] is planned, [[uric acid]] levels, [[beta-2-microglobulin]], pregnancy testing in woman of child-bearing age, [[flow cytometry]], [[immunohistochemistry]], [[genetic testing]] and [[FISH]].
==Laboratory tests==
==Laboratory tests==
Laboratory tests for [[mantle cell lymphoma]] include:<ref>https://www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf</ref>
Laboratory tests for mantle cell lymphoma include:<ref>https://www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf</ref>
* [[Complete blood count]] (CBC) with differential count
* [[Complete blood count]] (CBC) with differential count
:* [[Pancytopenia]] or a [[leukemic]] presentation with extensive [[leukocytosis]].<ref>{{Cite journal
:* [[Pancytopenia]] or a [[leukemic]] presentation with extensive [[leukocytosis]].<ref>{{Cite journal
Line 107: Line 107:
:* [[Chromosomal translocation|Translocation]] t(11;14)(q13;q32) in virtually all cases
:* [[Chromosomal translocation|Translocation]] t(11;14)(q13;q32) in virtually all cases
:* [[Mutation]] or deletions of ''[[ATM]] gene''
:* [[Mutation]] or deletions of ''[[ATM]] gene''
* [[FISH]] ([[fluorescence in situ hybridization]]): [[FISH]] can be used to detect the [[Chromosomal translocation|translocation]] t(11;14), which is found in most of [[MCL]] patients.<ref>{{Cite journal
* [[FISH]] ([[fluorescence in situ hybridization]]):  
** [[FISH]] can be used to detect the [[Chromosomal translocation|translocation]] t(11;14), which is found in most of [[MCL]] patients.<ref>{{Cite journal
  | author = [[Tsieh Sun]], [[Mary Lowery Nordberg]], [[James D. Cotelingam]], [[Diana M. Veillon]] & [[John Ryder]]
  | author = [[Tsieh Sun]], [[Mary Lowery Nordberg]], [[James D. Cotelingam]], [[Diana M. Veillon]] & [[John Ryder]]
  | title = Fluorescence in situ hybridization: method of choice for a definitive diagnosis of mantle cell lymphoma
  | title = Fluorescence in situ hybridization: method of choice for a definitive diagnosis of mantle cell lymphoma
Line 119: Line 120:
  | pmid = 12949897
  | pmid = 12949897
}}</ref>
}}</ref>
* [[PCR]]<ref>{{Cite journal
| author = [[Francesco Bertoni]] & [[Maurilio Ponzoni]]
| title = The cellular origin of mantle cell lymphoma
| journal = [[The international journal of biochemistry & cell biology]]
| volume = 39
| issue = 10
| pages = 1747–1753
| year = 2007
| month =
| doi = 10.1016/j.biocel.2007.04.026
| pmid = 17574898
}}</ref>
:*[[Polymerase chain reaction]] ([[PCR]]) is an additional method but is less often used nowadays.
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Revision as of 20:04, 7 January 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]

Overview

Laboratory tests for mantle cell lymphoma include complete blood count (CBC), comprehensive metabolic panel, LDH levels, Hepatitis B testing if treatment with rituximab is planned, uric acid levels, beta-2-microglobulin, pregnancy testing in woman of child-bearing age, flow cytometry, immunohistochemistry, genetic testing and FISH.

Laboratory tests

Laboratory tests for mantle cell lymphoma include:[1]

References

  1. ↑ https://www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf
  2. ↑ Ana Ferrer, Itziar Salaverria, Francesc Bosch, Neus Villamor, Maria Rozman, Silvia Bea, Eva Gine, Armando Lopez-Guillermo, Elias Campo & Emili Montserrat (2007). "Leukemic involvement is a common feature in mantle cell lymphoma". Cancer. 109 (12): 2473–2480. doi:10.1002/cncr.22715. PMID 17477385. Unknown parameter |month= ignored (help)
  3. ↑ Julie M. Vose (2017). "Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management". American journal of hematology. 92 (8): 806–813. doi:10.1002/ajh.24797. PMID 28699667. Unknown parameter |month= ignored (help)
  4. ↑ Julie M. Vose (2017). "Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management". American journal of hematology. 92 (8): 806–813. doi:10.1002/ajh.24797. PMID 28699667. Unknown parameter |month= ignored (help)
  5. ↑ Arturo Ciccullo, F. R. Ponziani, E. Maiolo, F. Pallavicini & M. Pompili (2018). "Late reactivation of hepatitis B virus after rituximab-containing chemotherapy for mantle cell lymphoma: a case report". Infection. doi:10.1007/s15010-018-1242-1. PMID 30368733. Unknown parameter |month= ignored (help)
  6. ↑ Julie M. Vose (2017). "Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management". American journal of hematology. 92 (8): 806–813. doi:10.1002/ajh.24797. PMID 28699667. Unknown parameter |month= ignored (help)
  7. ↑ Francesco Bertoni, Emanuele Zucca & Finbarr E. Cotter (2004). "Molecular basis of mantle cell lymphoma". British journal of haematology. 124 (2): 130–140. PMID 14687022. Unknown parameter |month= ignored (help)
  8. ↑ Chan Yoon Cheah, John F. Seymour & Michael L. Wang (2016). "Mantle Cell Lymphoma". Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 34 (11): 1256–1269. doi:10.1200/JCO.2015.63.5904. PMID 26755518. Unknown parameter |month= ignored (help)
  9. ↑ Jordi Camps, Itziar Salaverria, Maria J. Garcia, Esther Prat, Silvia Bea, Jessica C. Pole, Lluis Hernandez, Javier Del Rey, Juan Cruz Cigudosa, Marta Bernues, Carlos Caldas, Dolors Colomer, Rosa Miro & Elias Campo (2006). "Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines". Leukemia research. 30 (8): 923–934. doi:10.1016/j.leukres.2005.11.013. PMID 16448697. Unknown parameter |month= ignored (help)
  10. ↑ Tsieh Sun, Mary Lowery Nordberg, James D. Cotelingam, Diana M. Veillon & John Ryder (2003). "Fluorescence in situ hybridization: method of choice for a definitive diagnosis of mantle cell lymphoma". American journal of hematology. 74 (1): 78–84. doi:10.1002/ajh.10356. PMID 12949897. Unknown parameter |month= ignored (help)

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