Pseudomyxoma peritonei causes: Difference between revisions
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*The primary tumor appears to arise from the [[MUC2]] expressing [[goblet cell]]s and most commonly from these cells in the appendix. | *The primary tumor appears to arise from the [[MUC2]] expressing [[goblet cell]]s and most commonly from these cells in the appendix. | ||
*The ''K-Ras'' and ''p53'' genes may be involved in the oncogenesis. It may be diagnosed with a range of conditions. | *The ''K-Ras'' and ''p53'' genes may be involved in the oncogenesis. It may be diagnosed with a range of conditions. | ||
*While the majority of pseudomyxoma peritonei are associated with appendiceal carcinomas, | *While the majority of pseudomyxoma peritonei are associated with appendiceal carcinomas, other conditions may also be found, including disseminated peritoneal adenomucinosis (DPAM), peritoneal carcinomas, or several [[mucinous]] tumors (mucinous adenocarcinoma, mucinous cystadenoma, and mucinous cystadenocarcinoma).<ref name=Jacquemin_2005>{{cite journal |author=Jacquemin G, Laloux P |title=Pseudomyxoma peritonei: review on a cluster of peritoneal mucinous diseases |journal=Acta Chir Belg |volume=105 |issue=2 |pages=127–33 |year=2005 |pmid=15906901}}</ref> | ||
== References == | == References == | ||
Revision as of 15:38, 9 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Pseudomyxoma peritonei is caused by a pre-existing intraperitoneal mucinous neoplasm. The K-Ras and p53 genes may be involved in the oncogenesis.
Causes
- Since initial descriptions of pseudomyxoma peritonei as a syndrome in association with an ovarian tumor or an appendiceal mucocele, a pre-existing intraperitoneal mucinous neoplasm has been implicated as the primary cause of pseudomyxoma peritonei.
- Emerging evidence supports the appendiceal rather than ovarian origin of the disease.[1]
- The primary tumor appears to arise from the MUC2 expressing goblet cells and most commonly from these cells in the appendix.
- The K-Ras and p53 genes may be involved in the oncogenesis. It may be diagnosed with a range of conditions.
- While the majority of pseudomyxoma peritonei are associated with appendiceal carcinomas, other conditions may also be found, including disseminated peritoneal adenomucinosis (DPAM), peritoneal carcinomas, or several mucinous tumors (mucinous adenocarcinoma, mucinous cystadenoma, and mucinous cystadenocarcinoma).[2]
References
- ↑ Amini, Afshin; Masoumi-Moghaddam, Samar; Ehteda, Anahid; Morris, David (2014). "Secreted mucins in pseudomyxoma peritonei: pathophysiological significance and potential therapeutic prospects". Orphanet Journal of Rare Diseases. 9 (1): 71. doi:10.1186/1750-1172-9-71. ISSN 1750-1172.
- ↑ Jacquemin G, Laloux P (2005). "Pseudomyxoma peritonei: review on a cluster of peritoneal mucinous diseases". Acta Chir Belg. 105 (2): 127–33. PMID 15906901.