| Dock5 shares significant [[sequence identity]] with Dock180, the archetypal member of the DOCK family. It is therefore predicted to partake in similar [[protein-protein interactions|interactions]] although this has yet to be demonstrated. Indeed, the function and signalling properties of Dock5 are poorly understood thus far. Dock5 has been identified as a crucial signalling protein in [[osteoclasts]],<ref name="Ha_2008">{{cite journal | vauthors = Ha BG, Hong JM, Park JY | title = Proteomic profile of osteoclast membrane proteins: identification of Na+/H+ exchanger domain containing 2 and its role in osteoclast fusion | journal = Proteomics | volume = 8 | issue = 13 | pages = 2625–39|date=July 2008 | pmid = 18600791 | doi = 10.1002/pmic.200701192| url = }}</ref> and suppression of Dock5 [[gene expression|expression]] with [[shRNA]] has been shown to inhibit survival and [[Cellular differentiation|differentiation]] of osteoclast precursor cells.<ref name="Brazier_2006">{{cite journal | vauthors = Brazier H, Stephens S, Ory S | title = Expression profile of RhoGTPases and RhoGEFs during RANKL-stimulated osteoclastogenesis: identification of essential genes in osteoclasts | journal = J. Bone Min. Res. | volume = 21 | issue = 9 | pages = 1387–98 |date=September 2006 | pmid = 16939397 | doi = 10.1359/jbmr.060613| url = }}</ref> In addition, a mutation in Dock5 has been associated with the rupture of [[murine]] lens [[cataract]]s.<ref name="Omi_2008">{{cite journal | vauthors = Omi N, Kiyokawa E, Matsuda M | title = Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse| journal = Exp. Eye Res. | volume = 86 | issue = 5 | pages = 828–34|date=May 2008 | pmid = 18396277 | doi = 10.1016/j.exer.2008.02.011| url = }}</ref> In [[zebrafish]] Dock5 has been implicated in [[myogenesis|myoblast fusion]].<ref name="Moore_2007">{{cite journal | vauthors = Moore CA, Parkin CA, Bidet Y, Ingham PW| title = A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion| journal = Development | volume = 134 | issue = 17 | pages = 3145–53|date=September 2007 | pmid = 17670792 | doi = 10.1242/dev.001214| url = }}</ref> | | Dock5 shares significant [[sequence identity]] with Dock180, the archetypal member of the DOCK family. It is therefore predicted to partake in similar [[protein-protein interactions|interactions]] although this has yet to be demonstrated. Indeed, the function and signalling properties of Dock5 are poorly understood thus far. Dock5 has been identified as a crucial signalling protein in [[osteoclasts]],<ref name="Ha_2008">{{cite journal | vauthors = Ha BG, Hong JM, Park JY | title = Proteomic profile of osteoclast membrane proteins: identification of Na+/H+ exchanger domain containing 2 and its role in osteoclast fusion | journal = Proteomics | volume = 8 | issue = 13 | pages = 2625–39|date=July 2008 | pmid = 18600791 | doi = 10.1002/pmic.200701192| url = }}</ref> and suppression of Dock5 [[gene expression|expression]] with [[shRNA]] has been shown to inhibit survival and [[Cellular differentiation|differentiation]] of osteoclast precursor cells.<ref name="Brazier_2006">{{cite journal | vauthors = Brazier H, Stephens S, Ory S | title = Expression profile of RhoGTPases and RhoGEFs during RANKL-stimulated osteoclastogenesis: identification of essential genes in osteoclasts | journal = J. Bone Miner. Res. | volume = 21 | issue = 9 | pages = 1387–98 |date=September 2006 | pmid = 16939397 | doi = 10.1359/jbmr.060613| url = }}</ref> In addition, a mutation in Dock5 has been associated with the rupture of [[murine]] lens [[cataract]]s.<ref name="Omi_2008">{{cite journal | vauthors = Omi N, Kiyokawa E, Matsuda M | title = Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse| journal = Exp. Eye Res. | volume = 86 | issue = 5 | pages = 828–34|date=May 2008 | pmid = 18396277 | doi = 10.1016/j.exer.2008.02.011| url = http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/124225/3/yigak03266.pdf}}</ref> In [[zebrafish]] Dock5 has been implicated in [[myogenesis|myoblast fusion]].<ref name="Moore_2007">{{cite journal | vauthors = Moore CA, Parkin CA, Bidet Y, Ingham PW| title = A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion| journal = Development | volume = 134 | issue = 17 | pages = 3145–53|date=September 2007 | pmid = 17670792 | doi = 10.1242/dev.001214| url = }}</ref> |
