Surfactant protein A: Difference between revisions
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'''Surfactant protein A''' is an [[innate immune system]] [[collectin]]. It is water-soluble and has collagen-like domains similar to [[SP-D]]. It is part of the innate immune system and is used to opsonize bacterial cells in the [[alveoli]] marking them for [[phagocytosis]] by alveolar [[macrophages]]. SP-A may also play a role in negative feedback limiting the secretion of pulmonary surfactant. SP-A is not required for [[pulmonary surfactant]] to function but does confer immune effects to the organism.<ref>Boron W, Boulpaep E | '''Surfactant protein A''' is an [[innate immune system]] [[collectin]]. It is water-soluble and has collagen-like domains similar to [[SP-D]]. It is part of the innate immune system and is used to opsonize bacterial cells in the [[alveoli]] marking them for [[phagocytosis]] by alveolar [[macrophages]]. SP-A may also play a role in negative feedback limiting the secretion of pulmonary surfactant. SP-A is not required for [[pulmonary surfactant]] to function but does confer immune effects to the organism.<ref>{{cite book | vauthors = Boron W, Boulpaep E | title = Medical Physiology | edition = 2nd | location = Philadelphia | publisher = Elsevier | year = 2012 }}</ref> | ||
== During Parturition == | == During Parturition == | ||
The role of Surfactant protein A (or SP-A) in childbirth is indicated in studies with mice.<ref name="texas">{{cite journal | | The role of Surfactant protein A (or SP-A) in childbirth is indicated in studies with mice.<ref name="texas">{{cite journal | vauthors = Condon JC, Jeyasuria P, Faust JM, Mendelson CR | title = Surfactant protein secreted by the maturing mouse fetal lung acts as a hormone that signals the initiation of parturition | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 14 | pages = 4978–83 | date = April 2004 | pmid = 15044702 | pmc = 387359 | doi = 10.1073/pnas.0401124101 | jstor = 3371804 }}</ref> Mice which gestate for 19 days typically show signs of SP-A in amniotic fluid at around 16 days. If SP-A is injected into the uterus at 15 days, mice typically deliver early. Inversely, an SP-A inhibitor injection causes notable delays in birth. | ||
The presence of Surfactant Protein A seemed to trigger an inflammatory response in the uterus of the mice, but later studies found an anti-inflammatory response in humans.<ref name="lee">{{cite journal | | The presence of Surfactant Protein A seemed to trigger an inflammatory response in the uterus of the mice, but later studies found an anti-inflammatory response in humans.<ref name="lee">{{cite journal | vauthors = Lee DC, Romero R, Kim CJ, Chaiworapongsa T, Tarca AL, Lee J, Suh YL, Mazaki-Tovi S, Vaisbuch E, Mittal P, Draghici S, Erez O, Kusanovic JP, Hassan SS, Kim JS | title = Surfactant protein-A as an anti-inflammatory component in the amnion: implications for human pregnancy | journal = Journal of Immunology | volume = 184 | issue = 11 | pages = 6479–91 | date = June 2010 | pmid = 20439915 | pmc = 3103775 | doi = 10.4049/jimmunol.0903867 }}</ref> In fact, the level of SP-A in a human uterus typically decreases during labor. | ||
==Immune Functions== | ==Immune Functions== | ||
Research on SP-A has been done mainly in rodents including mice and rats. This research has shown that mice deficient in SP-A are more susceptible to infections from group B Streptoccoal organisms,<ref>{{ | Research on SP-A has been done mainly in rodents including mice and rats. This research has shown that mice deficient in SP-A are more susceptible to infections from group B Streptoccoal organisms,<ref>{{cite journal | vauthors = LeVine AM, Bruno MD, Huelsman KM, Ross GF, Whitsett JA, Korfhagen TR | title = Surfactant protein A-deficient mice are susceptible to group B streptococcal infection | journal = Journal of Immunology | volume = 158 | issue = 9 | pages = 4336–40 | date = May 1997 | pmid = 9126996 | url = http://www.jimmunol.org/content/158/9/4336 }}</ref> Pseudomonas aeruginosa,<ref>{{cite journal | vauthors = LeVine AM, Kurak KE, Bruno MD, Stark JM, Whitsett JA, Korfhagen TR | title = Surfactant protein-A-deficient mice are susceptible to Pseudomonas aeruginosa infection | journal = American Journal of Respiratory Cell and Molecular Biology | volume = 19 | issue = 4 | pages = 700–8 | date = October 1998 | pmid = 9761768 | doi = 10.1165/ajrcmb.19.4.3254 }}</ref> and likely other organisms. The immune functions of SP-A are time, temperature, and concentration dependant.<ref>{{cite journal | vauthors = van Iwaarden F, Welmers B, Verhoef J, Haagsman HP, van Golde LM | title = Pulmonary surfactant protein A enhances the host-defense mechanism of rat alveolar macrophages | journal = American Journal of Respiratory Cell and Molecular Biology | volume = 2 | issue = 1 | pages = 91–8 | date = January 1990 | pmid = 2306370 | doi = 10.1165/ajrcmb/2.1.91 }}</ref> | ||
==Location== | ==Location== | ||
SP-A is found in the pulmonary surfactant in lungs. SP-A and SP-D are also present in extrapulmonary tissues.<ref>{{cite journal| title= Surfactant-associated proteins: functions and structural variation | SP-A is found in the pulmonary surfactant in lungs. SP-A and SP-D are also present in extrapulmonary tissues.<ref>{{cite journal | vauthors = Haagsman HP, Diemel RV | title = Surfactant-associated proteins: functions and structural variation | journal = Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology | volume = 129 | issue = 1 | pages = 91–108 | date = May 2001 | pmid = 11369536 }}</ref> | ||
==See also== | == See also == | ||
* [[pulmonary surfactant]] | * [[pulmonary surfactant]] | ||
* [[SFTPA1]] | * [[SFTPA1]] | ||
* [[SFTPA2]] | * [[SFTPA2]] | ||
==External links== | == External links == | ||
* {{MeshName|Surfactant+Protein+A}} | * {{MeshName|Surfactant+Protein+A}} | ||
==References== | == References == | ||
{{reflist}} | {{reflist|32em}} | ||
[[Category:Collectins]] | [[Category:Collectins]] | ||
{{biochem-stub}} | {{biochem-stub}} | ||
Latest revision as of 14:07, 6 February 2018
| surfactant, pulmonary-associated protein A1 | |
|---|---|
| Identifiers | |
| Symbol | SFTPA1 |
| Alt. symbols | SFTP1 |
| Entrez | 6435 |
| HUGO | 10798 |
| OMIM | 178630 |
| RefSeq | NM_005411 |
| UniProt | Q8IWL2 |
| Other data | |
| Locus | Chr. 10 q22.3 |
| surfactant, pulmonary-associated protein A2B | |
|---|---|
| Identifiers | |
| Symbol | SFTPA2B |
| Entrez | 6436 |
| HUGO | 10799 |
| OMIM | 178642 |
| RefSeq | NM_006926 |
| UniProt | Q8IWL1 |
| Other data | |
| Locus | Chr. 10 q22.3 |
Surfactant protein A is an innate immune system collectin. It is water-soluble and has collagen-like domains similar to SP-D. It is part of the innate immune system and is used to opsonize bacterial cells in the alveoli marking them for phagocytosis by alveolar macrophages. SP-A may also play a role in negative feedback limiting the secretion of pulmonary surfactant. SP-A is not required for pulmonary surfactant to function but does confer immune effects to the organism.[1]
During Parturition
The role of Surfactant protein A (or SP-A) in childbirth is indicated in studies with mice.[2] Mice which gestate for 19 days typically show signs of SP-A in amniotic fluid at around 16 days. If SP-A is injected into the uterus at 15 days, mice typically deliver early. Inversely, an SP-A inhibitor injection causes notable delays in birth.
The presence of Surfactant Protein A seemed to trigger an inflammatory response in the uterus of the mice, but later studies found an anti-inflammatory response in humans.[3] In fact, the level of SP-A in a human uterus typically decreases during labor.
Immune Functions
Research on SP-A has been done mainly in rodents including mice and rats. This research has shown that mice deficient in SP-A are more susceptible to infections from group B Streptoccoal organisms,[4] Pseudomonas aeruginosa,[5] and likely other organisms. The immune functions of SP-A are time, temperature, and concentration dependant.[6]
Location
SP-A is found in the pulmonary surfactant in lungs. SP-A and SP-D are also present in extrapulmonary tissues.[7]
See also
External links
- Surfactant+Protein+A at the US National Library of Medicine Medical Subject Headings (MeSH)
References
- ↑ Boron W, Boulpaep E (2012). Medical Physiology (2nd ed.). Philadelphia: Elsevier.
- ↑ Condon JC, Jeyasuria P, Faust JM, Mendelson CR (April 2004). "Surfactant protein secreted by the maturing mouse fetal lung acts as a hormone that signals the initiation of parturition". Proceedings of the National Academy of Sciences of the United States of America. 101 (14): 4978–83. doi:10.1073/pnas.0401124101. JSTOR 3371804. PMC 387359. PMID 15044702.
- ↑ Lee DC, Romero R, Kim CJ, Chaiworapongsa T, Tarca AL, Lee J, Suh YL, Mazaki-Tovi S, Vaisbuch E, Mittal P, Draghici S, Erez O, Kusanovic JP, Hassan SS, Kim JS (June 2010). "Surfactant protein-A as an anti-inflammatory component in the amnion: implications for human pregnancy". Journal of Immunology. 184 (11): 6479–91. doi:10.4049/jimmunol.0903867. PMC 3103775. PMID 20439915.
- ↑ LeVine AM, Bruno MD, Huelsman KM, Ross GF, Whitsett JA, Korfhagen TR (May 1997). "Surfactant protein A-deficient mice are susceptible to group B streptococcal infection". Journal of Immunology. 158 (9): 4336–40. PMID 9126996.
- ↑ LeVine AM, Kurak KE, Bruno MD, Stark JM, Whitsett JA, Korfhagen TR (October 1998). "Surfactant protein-A-deficient mice are susceptible to Pseudomonas aeruginosa infection". American Journal of Respiratory Cell and Molecular Biology. 19 (4): 700–8. doi:10.1165/ajrcmb.19.4.3254. PMID 9761768.
- ↑ van Iwaarden F, Welmers B, Verhoef J, Haagsman HP, van Golde LM (January 1990). "Pulmonary surfactant protein A enhances the host-defense mechanism of rat alveolar macrophages". American Journal of Respiratory Cell and Molecular Biology. 2 (1): 91–8. doi:10.1165/ajrcmb/2.1.91. PMID 2306370.
- ↑ Haagsman HP, Diemel RV (May 2001). "Surfactant-associated proteins: functions and structural variation". Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology. 129 (1): 91–108. PMID 11369536.
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