BRMS1: Difference between revisions

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| summary_text = This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.<ref>[http://www.sciencedaily.com/releases/2000/06/000612084928.htm Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene<!-- Bot generated title -->]</ref> The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: BRMS1 breast cancer metastasis suppressor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25855| accessdate = }}</ref>
| summary_text = This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.<ref>[https://www.sciencedaily.com/releases/2000/06/000612084928.htm Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene<!-- Bot generated title -->]</ref> The protein encoded by this gene localizes primarily to the [[cell nucleus|nucleus]] and is a component of the [[mSin3a]] family of [[histone deacetylase]] complexes (HDAC). The protein contains two [[coiled-coil]] [[Structural motif|motif]]s and several imperfect [[leucine]] [[zipper motif]]s. [[Alternative splicing]] results in two [[primary transcript|transcript]] variants encoding different [[protein isoform|isoform]]s.<ref name="entrez">{{cite web | title = Entrez Gene: BRMS1 breast cancer metastasis suppressor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25855| accessdate = }}</ref>
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Revision as of 19:56, 28 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Breast cancer metastasis-suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.[1][2]

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.[3] The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.[2]

References

  1. ↑ Seraj MJ, Samant RS, Verderame MF, Welch DR (Jun 2000). "Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13". Cancer Res. 60 (11): 2764–9. PMID 10850410.
  2. ↑ 2.0 2.1 "Entrez Gene: BRMS1 breast cancer metastasis suppressor 1".
  3. ↑ Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene

External links

Further reading



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