P87PIKAP: Difference between revisions

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'''p87<sup>PIKAP</sup>''' is a regulatory subunit of the type IB [[Phosphoinositide]] 3-Kinase p110γ that is highly expressed in the [[heart]] and is present in [[dendritic cells]], [[macrophages]], and [[neutrophils]].<ref name="pmid16476736">{{cite journal | vauthors = Voigt P, Dorner MB, Schaefer M | title = Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B | journal = The Journal of Biological Chemistry | volume = 281 | issue = 15 | pages = 9977–86 | year = 2006 | pmid = 16476736 | doi = 10.1074/jbc.M512502200 }}</ref>
'''p87<sup>PIKAP</sup>''' is a regulatory subunit of the type IB [[Phosphoinositide]] 3-Kinase p110γ that is highly expressed in the [[heart]] and is present in [[dendritic cells]], [[macrophages]], and [[neutrophils]].<ref name="pmid16476736">{{cite journal | vauthors = Voigt P, Dorner MB, Schaefer M | title = Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B | journal = The Journal of Biological Chemistry | volume = 281 | issue = 15 | pages = 9977–86 | year = 2006 | pmid = 16476736 | doi = 10.1074/jbc.M512502200 }}</ref>
It is also referred to as p84 and p87.<ref name="pmid19906996">{{cite journal | vauthors = Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, Schaefer M, Gohla A, Harteneck C, Wymann MP, Jeanclos E, Nürnberg B | display-authors = 6 | title = Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 106 | issue = 48 | pages = 20312–7 | year = 2009 | pmid = 19906996 | pmc = 2787109 | doi = 10.1073/pnas.0905506106 }}</ref> Some studies have found P87PIKAP to have a role in [[carcinogenesis]].<ref>{{cite journal|title=Differential roles for the p101 and p84 regulatory subunits of PI3Kc in tumor growth and metastasis|url=https://www.nature.com/onc/journal/v31/n18/pdf/onc2011414a.pdf?origin=ppub|first1=JA |last1=Brazzatti|display-authors=etal|journal=Oncogene|date=2012|volume=31|pages=2350–2361}}</ref>
It is also referred to as p84 and p87.<ref name="pmid19906996">{{cite journal | vauthors = Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, Schaefer M, Gohla A, Harteneck C, Wymann MP, Jeanclos E, Nürnberg B | display-authors = 6 | title = Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 106 | issue = 48 | pages = 20312–7 | year = 2009 | pmid = 19906996 | pmc = 2787109 | doi = 10.1073/pnas.0905506106 }}</ref> Some studies have found P87PIKAP to have a role in [[carcinogenesis]].<ref>{{cite journal|title=Differential roles for the p101 and p84 regulatory subunits of PI3Kc in tumor growth and metastasis|url=https://www.nature.com/onc/journal/v31/n18/pdf/onc2011414a.pdf?origin=ppub|first1=JA |last1=Brazzatti|display-authors=etal|journal=Oncogene|date=2012|volume=31|pages=2350–2361|doi=10.1038/onc.2011.414}}</ref>


== References ==
== References ==
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{{biology-stub}}
{{protein-stub}}

Latest revision as of 14:07, 11 July 2018

Phosphoinositide-3-kinase adapter protein of 87 kDa
Identifiers
Symbolp87PIKAP
Alt. symbolsp84,PIK3R6
Entrez146850
HUGO27101
OMIM164730
RefSeqNM_005163
UniProtP31749
Other data
LocusChr. 17 p13.1

p87PIKAP is a regulatory subunit of the type IB Phosphoinositide 3-Kinase p110γ that is highly expressed in the heart and is present in dendritic cells, macrophages, and neutrophils.[1] It is also referred to as p84 and p87.[2] Some studies have found P87PIKAP to have a role in carcinogenesis.[3]

References

  1. ↑ Voigt P, Dorner MB, Schaefer M (2006). "Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B". The Journal of Biological Chemistry. 281 (15): 9977–86. doi:10.1074/jbc.M512502200. PMID 16476736.
  2. ↑ Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, et al. (2009). "Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma". Proceedings of the National Academy of Sciences of the United States of America. 106 (48): 20312–7. doi:10.1073/pnas.0905506106. PMC 2787109. PMID 19906996.
  3. ↑ Brazzatti, JA; et al. (2012). "Differential roles for the p101 and p84 regulatory subunits of PI3Kc in tumor growth and metastasis" (PDF). Oncogene. 31: 2350–2361. doi:10.1038/onc.2011.414.
File:Intro scheme3.jpg
The context of the function of p87.


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