MAP4K1: Difference between revisions

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'''Mitogen-activated protein kinase kinase kinase kinase 1''' is a [[protein kinase]] that in humans is encoded by the ''MAP4K1'' [[gene]].<ref name="pmid8824585">{{cite journal | vauthors = Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH | title = Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade | journal = Genes Dev | volume = 10 | issue = 18 | pages = 2251–64 | date = Dec 1996 | pmid = 8824585 | pmc =  | doi = 10.1101/gad.10.18.2251 }}</ref> It is also known as HPK1 (Hematopoietic Progenitor Kinase 1).
'''Mitogen-activated protein kinase kinase kinase kinase 1''' is a [[protein kinase]] that in humans is encoded by the ''MAP4K1'' [[gene]].<ref name="pmid8824585">{{cite journal | vauthors = Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH | title = Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade | journal = Genes Dev | volume = 10 | issue = 18 | pages = 2251–64 | date = Dec 1996 | pmid = 8824585 | pmc =  | doi = 10.1101/gad.10.18.2251 }}</ref> It is also known as HPK1 (Hematopoietic Progenitor Kinase 1). The protein has been shown to play a role in [[c-Jun N-terminal kinases|JNK]] activation.<ref>{{cite journal|title=MAP4K Family Kinases in Immunity and Inflammation|journal=Advanced Immunology|issue=129|pages=277–314|date=2016|doi=10.1016/bs.ai.2015.09.006|last1=Chuang |first1=HC|last2=Wang |first2=X|last3=Tan |first3=TH|pmid=26791862}}</ref>


== Interactions ==
== Interactions ==

Latest revision as of 14:41, 26 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
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Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene.[1] It is also known as HPK1 (Hematopoietic Progenitor Kinase 1). The protein has been shown to play a role in JNK activation.[2]

Interactions

MAP4K1 has been shown to interact with:

References

  1. ↑ Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH (Dec 1996). "Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade". Genes Dev. 10 (18): 2251–64. doi:10.1101/gad.10.18.2251. PMID 8824585.
  2. ↑ Chuang, HC; Wang, X; Tan, TH (2016). "MAP4K Family Kinases in Immunity and Inflammation". Advanced Immunology (129): 277–314. doi:10.1016/bs.ai.2015.09.006. PMID 26791862.
  3. ↑ Tsuji S, Okamoto M, Yamada K, Okamoto N, Goitsuka R, Arnold R, Kiefer F, Kitamura D (Aug 2001). "B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1". J. Exp. Med. 194 (4): 529–39. doi:10.1084/jem.194.4.529. PMC 2193495. PMID 11514608.
  4. ↑ 4.0 4.1 4.2 Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS, Blenis J, Tan TH, Feller SM (Oct 1998). "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". Oncogene. 17 (15): 1893–901. doi:10.1038/sj.onc.1202108. PMID 9788432.
  5. ↑ 5.0 5.1 5.2 5.3 Ling P, Yao Z, Meyer CF, Wang XS, Oehrl W, Feller SM, Tan TH (Feb 1999). "Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase". Mol. Cell. Biol. 19 (2): 1359–68. PMC 116064. PMID 9891069.
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Ling P, Meyer CF, Redmond LP, Shui JW, Davis B, Rich RR, Hu MC, Wange RL, Tan TH (Jun 2001). "Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling". J. Biol. Chem. 276 (22): 18908–14. doi:10.1074/jbc.M101485200. PMID 11279207.
  7. ↑ Ensenat D, Yao Z, Wang XS, Kori R, Zhou G, Lee SC, Tan TH (Nov 1999). "A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1". J. Biol. Chem. 274 (48): 33945–50. doi:10.1074/jbc.274.48.33945. PMID 10567356.
  8. ↑ Ma W, Xia C, Ling P, Qiu M, Luo Y, Tan TH, Liu M (Mar 2001). "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes". Oncogene. 20 (14): 1703–14. doi:10.1038/sj.onc.1204224. PMID 11313918.
  9. ↑ 9.0 9.1 Anafi M, Kiefer F, Gish GD, Mbamalu G, Iscove NN, Pawson T (Oct 1997). "SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1". J. Biol. Chem. 272 (44): 27804–11. doi:10.1074/jbc.272.44.27804. PMID 9346925.


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