HuD (protein): Difference between revisions
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'''HuD''' otherwise known as '''ELAV-like protein 4''' is a [[protein]] that in humans is encoded by the ''ELAVL4'' [[gene]].<ref name="pmid8222755">{{cite journal |vauthors=Muresu R, Baldini A, Gress T, Posner JB, Furneaux HM, Siniscalco M | title = Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34 | journal = Cytogenet Cell Genet | volume = 65 | issue = 3 | pages = 177–8 |date=Dec 1993 | pmid = 8222755 | pmc = | doi =10.1159/000133626 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1996| accessdate = }}</ref> | '''HuD''' otherwise known as '''ELAV-like protein 4''' is a [[protein]] that in humans is encoded by the ''ELAVL4'' [[gene]].<ref name="pmid8222755">{{cite journal |vauthors=Muresu R, Baldini A, Gress T, Posner JB, Furneaux HM, Siniscalco M | title = Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34 | journal = Cytogenet Cell Genet | volume = 65 | issue = 3 | pages = 177–8 |date=Dec 1993 | pmid = 8222755 | pmc = | doi =10.1159/000133626 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1996| accessdate = }}</ref> | ||
The HuD/ELAVL4 protein is an [[RNA-binding protein]].<ref>{{cite journal |vauthors=Szabo A, Dalmau J, Manley G, etal |title=HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal. |journal=Cell |volume=67 |issue= 2 |pages= 325–33 |year= 1991 |pmid= 1655278 |doi=10.1016/0092-8674(91)90184-Z }}</ref> | The HuD/ELAVL4 protein is an [[RNA-binding protein]].<ref>{{cite journal |vauthors=Szabo A, Dalmau J, Manley G, etal |title=HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal. |journal=Cell |volume=67 |issue= 2 |pages= 325–33 |year= 1991 |pmid= 1655278 |doi=10.1016/0092-8674(91)90184-Z }}</ref> HuD contains three [[RNA recognition motif|RRM]] [[Protein domain|protein domains]], enabling RNA binding.<ref>{{Cite journal|date=2008-08-01|title=RNA-binding proteins in human genetic disease|url=https://www.sciencedirect.com/science/article/pii/S016895250800173X|journal=Trends in Genetics|language=en|volume=24|issue=8|pages=416–425|doi=10.1016/j.tig.2008.05.004|issn=0168-9525}}</ref> | ||
HuD is expressed only in neurons and it binds to [[AU-rich element]]-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.<ref>{{cite journal |author1=Nora Perrone-Bizzozero |author2=Federico Bolognani |title=Role of HuD and other RNA-binding proteins in neural development and plasticity |journal=J Neurosci Res |volume=68 |issue=2 |pages=121–126 |year=2002 |pmid=11948657 |doi=10.1002/jnr.10175}}</ref><ref>{{cite journal |author1=Federico Bolognani |author2=Nora Perrone-Bizzozero |title=RNA-protein interactions and control of mRNA stability in neurons |journal=J Neurosci Res |volume=86 |issue= 3 |pages=481–489 |year=2008 |pmid=17853436 |doi=10.1002/jnr.21473}}</ref> | HuD is expressed only in neurons and it binds to [[AU-rich element]]-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.<ref>{{cite journal |author1=Nora Perrone-Bizzozero |author2=Federico Bolognani |title=Role of HuD and other RNA-binding proteins in neural development and plasticity |journal=J Neurosci Res |volume=68 |issue=2 |pages=121–126 |year=2002 |pmid=11948657 |doi=10.1002/jnr.10175}}</ref><ref>{{cite journal |author1=Federico Bolognani |author2=Nora Perrone-Bizzozero |title=RNA-protein interactions and control of mRNA stability in neurons |journal=J Neurosci Res |volume=86 |issue= 3 |pages=481–489 |year=2008 |pmid=17853436 |doi=10.1002/jnr.21473}}</ref> | ||
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*{{cite journal |vauthors=Torà M, Graus F, de Bolòs C, Real FX |title=Cell surface expression of paraneoplastic encephalomyelitis/sensory neuronopathy-associated Hu antigens in small-cell lung cancers and neuroblastomas. |journal=Neurology |volume=48 |issue= 3 |pages= 735–41 |year= 1997 |pmid= 9065557 |doi= 10.1212/wnl.48.3.735}} | *{{cite journal |vauthors=Torà M, Graus F, de Bolòs C, Real FX |title=Cell surface expression of paraneoplastic encephalomyelitis/sensory neuronopathy-associated Hu antigens in small-cell lung cancers and neuroblastomas. |journal=Neurology |volume=48 |issue= 3 |pages= 735–41 |year= 1997 |pmid= 9065557 |doi= 10.1212/wnl.48.3.735}} | ||
*{{cite journal |vauthors=Lazarova DL, Spengler BA, Biedler JL, Ross RA |title=HuD, a neuronal-specific RNA-binding protein, is a putative regulator of N-myc pre-mRNA processing/stability in malignant human neuroblasts. |journal=Oncogene |volume=18 |issue= 17 |pages= 2703–10 |year= 1999 |pmid= 10348344 |doi= 10.1038/sj.onc.1202621 }} | *{{cite journal |vauthors=Lazarova DL, Spengler BA, Biedler JL, Ross RA |title=HuD, a neuronal-specific RNA-binding protein, is a putative regulator of N-myc pre-mRNA processing/stability in malignant human neuroblasts. |journal=Oncogene |volume=18 |issue= 17 |pages= 2703–10 |year= 1999 |pmid= 10348344 |doi= 10.1038/sj.onc.1202621 }} | ||
*{{cite journal |vauthors=Park S, Myszka DG, Yu M, etal |title=HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA. |journal=Mol. Cell. Biol. |volume=20 |issue= 13 |pages= 4765–72 |year= 2000 |pmid= 10848602 | pmc=85909 |doi=10.1128/MCB.20.13.4765-4772.2000 }} | *{{cite journal |vauthors=Park S, Myszka DG, Yu M, etal |title=HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA. |journal=Mol. Cell. Biol. |volume=20 |issue= 13 |pages= 4765–72 |year= 2000 |pmid= 10848602 | pmc=85909 |doi=10.1128/MCB.20.13.4765-4772.2000 |url=http://mcb.asm.org/content/20/13/4765.full.pdf }} | ||
*{{cite journal |vauthors=Wang X, Tanaka Hall TM |title=Structural basis for recognition of AU-rich element RNA by the HuD protein. |journal=Nat. Struct. Biol. |volume=8 |issue= 2 |pages= 141–5 |year= 2001 |pmid= 11175903 |doi= 10.1038/84131 }} | *{{cite journal |vauthors=Wang X, Tanaka Hall TM |title=Structural basis for recognition of AU-rich element RNA by the HuD protein. |journal=Nat. Struct. Biol. |volume=8 |issue= 2 |pages= 141–5 |year= 2001 |pmid= 11175903 |doi= 10.1038/84131 }} | ||
*{{cite journal |vauthors=Beckel-Mitchener AC, Miera A, Keller R, Perrone-Bizzozero NI |title=Poly(A) tail length-dependent stabilization of GAP-43 mRNA by the RNA-binding protein HuD. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27996–8002 |year= 2002 |pmid= 12034726 |doi= 10.1074/jbc.M201982200 }} | *{{cite journal |vauthors=Beckel-Mitchener AC, Miera A, Keller R, Perrone-Bizzozero NI |title=Poly(A) tail length-dependent stabilization of GAP-43 mRNA by the RNA-binding protein HuD. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27996–8002 |year= 2002 |pmid= 12034726 |doi= 10.1074/jbc.M201982200 }} | ||
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*{{cite journal |vauthors=Angenstein F, Evans AM, Settlage RE, etal |title=A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. |journal=J. Neurosci. |volume=22 |issue= 20 |pages= 8827–37 |year= 2002 |pmid= 12388589 |doi= }} | *{{cite journal |vauthors=Angenstein F, Evans AM, Settlage RE, etal |title=A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. |journal=J. Neurosci. |volume=22 |issue= 20 |pages= 8827–37 |year= 2002 |pmid= 12388589 |doi= }} | ||
*{{cite journal |vauthors=Deschenes-Furry J, Belanger G, Perrone-Bizzozero N, Jasmin BJ |title=Post-transcriptional regulation of acetylcholinesterase mRNAs in nerve growth factor-treated PC12 cells by the RNA-binding protein HuD. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 5710–7 |year= 2003 |pmid= 12468554 |doi= 10.1074/jbc.M209383200 }} | *{{cite journal |vauthors=Deschenes-Furry J, Belanger G, Perrone-Bizzozero N, Jasmin BJ |title=Post-transcriptional regulation of acetylcholinesterase mRNAs in nerve growth factor-treated PC12 cells by the RNA-binding protein HuD. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 5710–7 |year= 2003 |pmid= 12468554 |doi= 10.1074/jbc.M209383200 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 | pmc=139241 |doi= 10.1073/pnas.242603899 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 | pmc=139241 |doi= 10.1073/pnas.242603899 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Plonquet A, Garcia-Pons F, Fernandez E, etal |title=Peptides derived from the onconeural HuD protein can elicit cytotoxic responses in HHD mouse and human. |journal=J. Neuroimmunol. |volume=142 |issue= 1-2 |pages= 93–100 |year= 2004 |pmid= 14512168 |doi=10.1016/S0165-5728(03)00269-8 }} | *{{cite journal |vauthors=Plonquet A, Garcia-Pons F, Fernandez E, etal |title=Peptides derived from the onconeural HuD protein can elicit cytotoxic responses in HHD mouse and human. |journal=J. Neuroimmunol. |volume=142 |issue= 1-2 |pages= 93–100 |year= 2004 |pmid= 14512168 |doi=10.1016/S0165-5728(03)00269-8 }} | ||
*{{cite journal |vauthors=Saito K, Fujiwara T, Katahira J, etal |title=TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD. |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 2 |pages= 291–7 |year= 2004 |pmid= 15358174 |doi= 10.1016/j.bbrc.2004.06.140 }} | *{{cite journal |vauthors=Saito K, Fujiwara T, Katahira J, etal |title=TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD. |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 2 |pages= 291–7 |year= 2004 |pmid= 15358174 |doi= 10.1016/j.bbrc.2004.06.140 }} | ||
*{{cite journal |vauthors=Rousseau A, Benyahia B, Dalmau J, etal |title=T cell response to Hu-D peptides in patients with anti-Hu syndrome. |journal=J. Neurooncol. |volume=71 |issue= 3 |pages= 231–6 |year= 2005 |pmid= 15735910 | pmc=2586925 |doi= 10.1007/s11060-004-1723-1 }} | *{{cite journal |vauthors=Rousseau A, Benyahia B, Dalmau J, etal |title=T cell response to Hu-D peptides in patients with anti-Hu syndrome. |journal=J. Neurooncol. |volume=71 |issue= 3 |pages= 231–6 |year= 2005 |pmid= 15735910 | pmc=2586925 |doi= 10.1007/s11060-004-1723-1 }} | ||
*{{cite journal |vauthors=Noureddine MA, Qin XJ, Oliveira SA, etal |title=Association between the neuron-specific RNA-binding protein ELAVL4 and Parkinson disease. |journal=Hum. Genet. |volume=117 |issue= 1 |pages= 27–33 |year= 2005 |pmid= 15827745 |doi= 10.1007/s00439-005-1259-2 }} | *{{cite journal |vauthors=Noureddine MA, Qin XJ, Oliveira SA, etal |title=Association between the neuron-specific RNA-binding protein ELAVL4 and Parkinson disease. |journal=Hum. Genet. |volume=117 |issue= 1 |pages= 27–33 |year= 2005 |pmid= 15827745 |doi= 10.1007/s00439-005-1259-2 }} | ||
*{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }} | ||
}} | }} | ||
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HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene.[1][2]
The HuD/ELAVL4 protein is an RNA-binding protein.[3] HuD contains three RRM protein domains, enabling RNA binding.[4]
HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.[5][6]
Interactions
HuD (protein) has been shown to interact with NXF1.[7]
References
- ↑ Muresu R, Baldini A, Gress T, Posner JB, Furneaux HM, Siniscalco M (Dec 1993). "Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34". Cytogenet Cell Genet. 65 (3): 177–8. doi:10.1159/000133626. PMID 8222755.
- ↑ "Entrez Gene: ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)".
- ↑ Szabo A, Dalmau J, Manley G, et al. (1991). "HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal". Cell. 67 (2): 325–33. doi:10.1016/0092-8674(91)90184-Z. PMID 1655278.
- ↑ "RNA-binding proteins in human genetic disease". Trends in Genetics. 24 (8): 416–425. 2008-08-01. doi:10.1016/j.tig.2008.05.004. ISSN 0168-9525.
- ↑ Nora Perrone-Bizzozero; Federico Bolognani (2002). "Role of HuD and other RNA-binding proteins in neural development and plasticity". J Neurosci Res. 68 (2): 121–126. doi:10.1002/jnr.10175. PMID 11948657.
- ↑ Federico Bolognani; Nora Perrone-Bizzozero (2008). "RNA-protein interactions and control of mRNA stability in neurons". J Neurosci Res. 86 (3): 481–489. doi:10.1002/jnr.21473. PMID 17853436.
- ↑ Saito, Kuniaki; Fujiwara Toshinobu; Katahira Jun; Inoue Kunio; Sakamoto Hiroshi (Aug 2004). "TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD". Biochem. Biophys. Res. Commun. United States. 321 (2): 291–7. doi:10.1016/j.bbrc.2004.06.140. ISSN 0006-291X. PMID 15358174.
Further reading
- Dalmau J, Furneaux HM, Cordon-Cardo C, Posner JB (1992). "The expression of the Hu (paraneoplastic encephalomyelitis/sensory neuronopathy) antigen in human normal and tumor tissues". Am. J. Pathol. 141 (4): 881–6. PMC 1886624. PMID 1415481.
- Szabo A, Dalmau J, Manley G, et al. (1991). "HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal". Cell. 67 (2): 325–33. doi:10.1016/0092-8674(91)90184-Z. PMID 1655278.
- Graus F, Ferrer I (1990). "Analysis of a neuronal antigen (Hu) expression in the developing rat brain detected by autoantibodies from patients with paraneoplastic encephalomyelitis". Neurosci. Lett. 112 (1): 14–8. doi:10.1016/0304-3940(90)90314-Y. PMID 2166930.
- Sekido Y, Bader SA, Carbone DP, et al. (1994). "Molecular analysis of the HuD gene encoding a paraneoplastic encephalomyelitis antigen in human lung cancer cell lines". Cancer Res. 54 (18): 4988–92. PMID 8069866.
- Torà M, Graus F, de Bolòs C, Real FX (1997). "Cell surface expression of paraneoplastic encephalomyelitis/sensory neuronopathy-associated Hu antigens in small-cell lung cancers and neuroblastomas". Neurology. 48 (3): 735–41. doi:10.1212/wnl.48.3.735. PMID 9065557.
- Lazarova DL, Spengler BA, Biedler JL, Ross RA (1999). "HuD, a neuronal-specific RNA-binding protein, is a putative regulator of N-myc pre-mRNA processing/stability in malignant human neuroblasts". Oncogene. 18 (17): 2703–10. doi:10.1038/sj.onc.1202621. PMID 10348344.
- Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA" (PDF). Mol. Cell. Biol. 20 (13): 4765–72. doi:10.1128/MCB.20.13.4765-4772.2000. PMC 85909. PMID 10848602.
- Wang X, Tanaka Hall TM (2001). "Structural basis for recognition of AU-rich element RNA by the HuD protein". Nat. Struct. Biol. 8 (2): 141–5. doi:10.1038/84131. PMID 11175903.
- Beckel-Mitchener AC, Miera A, Keller R, Perrone-Bizzozero NI (2002). "Poly(A) tail length-dependent stabilization of GAP-43 mRNA by the RNA-binding protein HuD". J. Biol. Chem. 277 (31): 27996–8002. doi:10.1074/jbc.M201982200. PMID 12034726.
- Behrends U, Jandl T, Golbeck A, et al. (2002). "Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library". Int. J. Cancer. 100 (6): 669–77. doi:10.1002/ijc.10550. PMID 12209604.
- Aronov S, Aranda G, Behar L, Ginzburg I (2003). "Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules". J. Cell Sci. 115 (Pt 19): 3817–27. doi:10.1242/jcs.00058. PMID 12235292.
- Angenstein F, Evans AM, Settlage RE, et al. (2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons". J. Neurosci. 22 (20): 8827–37. PMID 12388589.
- Deschenes-Furry J, Belanger G, Perrone-Bizzozero N, Jasmin BJ (2003). "Post-transcriptional regulation of acetylcholinesterase mRNAs in nerve growth factor-treated PC12 cells by the RNA-binding protein HuD". J. Biol. Chem. 278 (8): 5710–7. doi:10.1074/jbc.M209383200. PMID 12468554.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Plonquet A, Garcia-Pons F, Fernandez E, et al. (2004). "Peptides derived from the onconeural HuD protein can elicit cytotoxic responses in HHD mouse and human". J. Neuroimmunol. 142 (1–2): 93–100. doi:10.1016/S0165-5728(03)00269-8. PMID 14512168.
- Saito K, Fujiwara T, Katahira J, et al. (2004). "TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD". Biochem. Biophys. Res. Commun. 321 (2): 291–7. doi:10.1016/j.bbrc.2004.06.140. PMID 15358174.
- Rousseau A, Benyahia B, Dalmau J, et al. (2005). "T cell response to Hu-D peptides in patients with anti-Hu syndrome". J. Neurooncol. 71 (3): 231–6. doi:10.1007/s11060-004-1723-1. PMC 2586925. PMID 15735910.
- Noureddine MA, Qin XJ, Oliveira SA, et al. (2005). "Association between the neuron-specific RNA-binding protein ELAVL4 and Parkinson disease". Hum. Genet. 117 (1): 27–33. doi:10.1007/s00439-005-1259-2. PMID 15827745.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
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