'''Major histocompatibility complex class I-related gene protein''' is a [[protein]] that in humans is encoded by the ''MR1'' [[gene]].<ref name="pmid7624800">{{cite journal |vauthors=Hashimoto K, Hirai M, Kurosawa Y | title = A gene outside the human MHC related to classical HLA class I genes | journal = Science | volume = 269 | issue = 5224 | pages = 693–5 |date=Aug 1995 | pmid = 7624800 | pmc = | doi =10.1126/science.7624800 }}</ref><ref name="pmid9784382">{{cite journal |vauthors=Yamaguchi H, Kurosawa Y, Hashimoto K | title = Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog | journal = Biochem Biophys Res Commun | volume = 250 | issue = 3 | pages = 558–64 |date=Nov 1998 | pmid = 9784382 | pmc = | doi = 10.1006/bbrc.1998.9353 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MR1 major histocompatibility complex, class I-related| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3140| accessdate = }}</ref> The MR1 protein is able to bind to molecules derived from bacterial riboflavin biosynthesis, and then present it to [[Mucosal associated invariant T cell|mucosal associated invariant T cells]] for activation.<ref>{{Cite journal|last=Corbett|first=Alexandra J.|last2=Eckle|first2=Sidonia B. G.|last3=Birkinshaw|first3=Richard W.|last4=Liu|first4=Ligong|last5=Patel|first5=Onisha|last6=Mahony|first6=Jennifer|last7=Chen|first7=Zhenjun|last8=Reantragoon|first8=Rangsima|last9=Meehan|first9=Bronwyn|title=T-cell activation by transitory neo-antigens derived from distinct microbial pathways|url=http://www.nature.com/doifinder/10.1038/nature13160|journal=Nature|volume=509|issue=7500|pages=361–365|doi=10.1038/nature13160}}</ref><ref>{{Cite journal|last=Kjer-Nielsen|first=Lars|last2=Patel|first2=Onisha|last3=Corbett|first3=Alexandra J.|last4=Nours|first4=Jérôme Le|last5=Meehan|first5=Bronwyn|last6=Liu|first6=Ligong|last7=Bhati|first7=Mugdha|last8=Chen|first8=Zhenjun|last9=Kostenko|first9=Lyudmila|title=MR1 presents microbial vitamin B metabolites to MAIT cells|url=http://www.nature.com/doifinder/10.1038/nature11605|journal=Nature|doi=10.1038/nature11605}}</ref>
'''Major histocompatibility complex class I-related gene protein''' is a [[protein]] that in humans is encoded by the ''MR1'' [[gene]].<ref name="pmid7624800">{{cite journal |vauthors=Hashimoto K, Hirai M, Kurosawa Y | title = A gene outside the human MHC related to classical HLA class I genes | journal = Science | volume = 269 | issue = 5224 | pages = 693–5 |date=Aug 1995 | pmid = 7624800 | pmc = | doi =10.1126/science.7624800 }}</ref><ref name="pmid9784382">{{cite journal |vauthors=Yamaguchi H, Kurosawa Y, Hashimoto K | title = Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog | journal = Biochem Biophys Res Commun | volume = 250 | issue = 3 | pages = 558–64 |date=Nov 1998 | pmid = 9784382 | pmc = | doi = 10.1006/bbrc.1998.9353 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MR1 major histocompatibility complex, class I-related| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3140| accessdate = }}</ref> Human MR1 protein has 341 amino acid residues with a molecular weight of 39 366.<ref name="UniProt">{{cite web|url=http://www.uniprot.org/uniprot/Q95460#sequences |title=UniProt, Q95460 }}</ref> The MR1 protein is able to bind to molecules derived from bacterial [[riboflavin]] [[biosynthesis]], and then present it to [[Mucosal associated invariant T cell|mucosal associated invariant T cells]] for activation.<ref>{{Cite journal|last=Corbett|first=Alexandra J.|last2=Eckle|first2=Sidonia B. G.|last3=Birkinshaw|first3=Richard W.|last4=Liu|first4=Ligong|last5=Patel|first5=Onisha|last6=Mahony|first6=Jennifer|last7=Chen|first7=Zhenjun|last8=Reantragoon|first8=Rangsima|last9=Meehan|first9=Bronwyn|title=T-cell activation by transitory neo-antigens derived from distinct microbial pathways|url=http://www.nature.com/doifinder/10.1038/nature13160|journal=Nature|volume=509|issue=7500|pages=361–365|doi=10.1038/nature13160}}</ref><ref>{{Cite journal|last=Kjer-Nielsen|first=Lars|last2=Patel|first2=Onisha|last3=Corbett|first3=Alexandra J.|last4=Nours|first4=Jérôme Le|last5=Meehan|first5=Bronwyn|last6=Liu|first6=Ligong|last7=Bhati|first7=Mugdha|last8=Chen|first8=Zhenjun|last9=Kostenko|first9=Lyudmila|title=MR1 presents microbial vitamin B metabolites to MAIT cells|url=http://www.nature.com/doifinder/10.1038/nature11605|journal=Nature|doi=10.1038/nature11605}}</ref>
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Major histocompatibility complex class I-related gene protein is a protein that in humans is encoded by the MR1gene.[1][2][3] Human MR1 protein has 341 amino acid residues with a molecular weight of 39 366.[4] The MR1 protein is able to bind to molecules derived from bacterial riboflavinbiosynthesis, and then present it to mucosal associated invariant T cells for activation.[5][6]
References
↑Hashimoto K, Hirai M, Kurosawa Y (Aug 1995). "A gene outside the human MHC related to classical HLA class I genes". Science. 269 (5224): 693–5. doi:10.1126/science.7624800. PMID7624800.
↑Yamaguchi H, Kurosawa Y, Hashimoto K (Nov 1998). "Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog". Biochem Biophys Res Commun. 250 (3): 558–64. doi:10.1006/bbrc.1998.9353. PMID9784382.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Yamaguchi H, Hirai M, Kurosawa Y, Hashimoto K (1997). "A highly conserved major histocompatibility complex class I-related gene in mammals". Biochem. Biophys. Res. Commun. 238 (3): 697–702. doi:10.1006/bbrc.1997.7379. PMID9325151.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Riegert P, Wanner V, Bahram S (1998). "Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene". J. Immunol. 161 (8): 4066–77. PMID9780177.
Parra-Cuadrado JF, Navarro P, Mirones I, et al. (2001). "A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene". Tissue Antigens. 56 (2): 170–2. doi:10.1034/j.1399-0039.2000.560211.x. PMID11019920.
Miley MJ, Truscott SM, Yu YY, et al. (2003). "Biochemical features of the MHC-related protein 1 consistent with an immunological function". J. Immunol. 170 (12): 6090–8. doi:10.4049/jimmunol.170.12.6090. PMID12794138.
Hempelmann A, Kumar S, Muralitharan S, Sander T (2007). "Myofibrillogenesis regulator 1 gene (MR-1) mutation in an Omani family with paroxysmal nonkinesigenic dyskinesia". Neurosci. Lett. 402 (1–2): 118–20. doi:10.1016/j.neulet.2006.03.048. PMID16632198.
