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* [[GPS2 (gene)|GPS2]],<ref name = pmid11931768/> and | * [[GPS2 (gene)|GPS2]],<ref name = pmid11931768/> and | ||
* [[HDAC3]],<ref name = pmid11931768/><ref name = pmid10809664/> | * [[HDAC3]],<ref name = pmid11931768/><ref name = pmid10809664/> | ||
* [[Nuclear receptor co-repressor 1|NCOA1]],<ref name = pmid11931768>{{cite journal | vauthors = Zhang J, Kalkum M, Chait BT, Roeder RG | title = The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 | journal = Mol. Cell | volume = 9 | issue = 3 | pages = 611–23 | date = March 2002 | pmid = 11931768 | doi = 10.1016/s1097-2765(02)00468-9}}</ref><ref name = pmid10809664>{{cite journal | vauthors = Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R | title = A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness | journal = Genes Dev. | volume = 14 | issue = 9 | pages = 1048–57 | date = May 2000 | pmid = 10809664 | pmc = 316569 | doi = 10.1101/gad.14.9.1048}}</ref><ref name = pmid12628926>{{cite journal | vauthors = Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J | title = Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1 | journal = EMBO J. | volume = 22 | issue = 6 | pages = 1336–46 | date = March 2003 | pmid = 12628926 | pmc = 151047 | doi = 10.1093/emboj/cdg120 }}</ref><ref name = pmid10944117>{{cite journal | vauthors = Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J | title = Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3 | journal = EMBO J. | volume = 19 | issue = 16 | pages = 4342–50 | date = August 2000 | pmid = 10944117 | pmc = 302030 | doi = 10.1093/emboj/19.16.4342 }}</ref> and | * [[Nuclear receptor co-repressor 1|NCOA1]],<ref name = pmid11931768>{{cite journal | vauthors = Zhang J, Kalkum M, Chait BT, Roeder RG | title = The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 | journal = Mol. Cell | volume = 9 | issue = 3 | pages = 611–23 | date = March 2002 | pmid = 11931768 | doi = 10.1016/s1097-2765(02)00468-9}}</ref><ref name = pmid10809664>{{cite journal | vauthors = Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R | title = A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness | journal = Genes Dev. | volume = 14 | issue = 9 | pages = 1048–57 | date = May 2000 | pmid = 10809664 | pmc = 316569 | doi = 10.1101/gad.14.9.1048| doi-broken-date = 2018-09-05 }}</ref><ref name = pmid12628926>{{cite journal | vauthors = Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J | title = Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1 | journal = EMBO J. | volume = 22 | issue = 6 | pages = 1336–46 | date = March 2003 | pmid = 12628926 | pmc = 151047 | doi = 10.1093/emboj/cdg120 }}</ref><ref name = pmid10944117>{{cite journal | vauthors = Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J | title = Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3 | journal = EMBO J. | volume = 19 | issue = 16 | pages = 4342–50 | date = August 2000 | pmid = 10944117 | pmc = 302030 | doi = 10.1093/emboj/19.16.4342 }}</ref> and | ||
* [[Nuclear receptor co-repressor 2|NCOA2]].<ref name = pmid10809664/><ref name = pmid12628926/><ref name = pmid10944117/><ref name = pmid12502735>{{cite journal | vauthors = Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA | title = Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex | journal = Genes Dev. | volume = 16 | issue = 24 | pages = 3130–5 | date = December 2002 | pmid = 12502735 | pmc = 187500 | doi = 10.1101/gad.1037502 }}</ref> | * [[Nuclear receptor co-repressor 2|NCOA2]].<ref name = pmid10809664/><ref name = pmid12628926/><ref name = pmid10944117/><ref name = pmid12502735>{{cite journal | vauthors = Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA | title = Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex | journal = Genes Dev. | volume = 16 | issue = 24 | pages = 3130–5 | date = December 2002 | pmid = 12502735 | pmc = 187500 | doi = 10.1101/gad.1037502 }}</ref> | ||
| Line 20: | Line 20: | ||
== Further reading == | == Further reading == | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Bassi MT, Ramesar RS, Caciotti B, Winship IM, De Grandi A, Riboni M, Townes PL, Beighton P, Ballabio A, Borsani G | title = X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats | * {{cite journal | vauthors = Bassi MT, Ramesar RS, Caciotti B, Winship IM, De Grandi A, Riboni M, Townes PL, Beighton P, Ballabio A, Borsani G | title = X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats | journal = Am. J. Hum. Genet. | volume = 64 | issue = 6 | pages = 1604–16 | year = 1999 | pmid = 10330347 | pmc = 1377903 | doi = 10.1086/302408 }} | ||
* {{cite journal | vauthors = Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R | title = A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness | * {{cite journal | vauthors = Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R | title = A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness | journal = Genes Dev. | volume = 14 | issue = 9 | pages = 1048–57 | year = 2000 | pmid = 10809664 | pmc = 316569 | doi = 10.1101/gad.14.9.1048| doi-broken-date = 2018-09-05 }} | ||
* {{cite journal | vauthors = Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J | title = Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3 | * {{cite journal | vauthors = Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J | title = Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3 | journal = EMBO J. | volume = 19 | issue = 16 | pages = 4342–50 | year = 2000 | pmid = 10944117 | pmc = 302030 | doi = 10.1093/emboj/19.16.4342 }} | ||
* {{cite journal | vauthors = Matsuzawa SI, Reed JC | title = Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses | * {{cite journal | vauthors = Matsuzawa SI, Reed JC | title = Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses | journal = Mol. Cell | volume = 7 | issue = 5 | pages = 915–26 | year = 2001 | pmid = 11389839 | doi = 10.1016/S1097-2765(01)00242-8 }} | ||
* {{cite journal | vauthors = Zhang J, Kalkum M, Chait BT, Roeder RG | title = The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 | * {{cite journal | vauthors = Zhang J, Kalkum M, Chait BT, Roeder RG | title = The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 | journal = Mol. Cell | volume = 9 | issue = 3 | pages = 611–23 | year = 2002 | pmid = 11931768 | doi = 10.1016/S1097-2765(02)00468-9 }} | ||
* {{cite journal | vauthors = Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J | title = Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1 | * {{cite journal | vauthors = Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J | title = Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1 | journal = EMBO J. | volume = 22 | issue = 6 | pages = 1336–46 | year = 2003 | pmid = 12628926 | pmc = 151047 | doi = 10.1093/emboj/cdg120 }} | ||
* {{cite journal | vauthors = Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J | title = N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso | * {{cite journal | vauthors = Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J | title = N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso | journal = Mol. Cell | volume = 12 | issue = 3 | pages = 723–34 | year = 2003 | pmid = 14527417 | doi = 10.1016/j.molcel.2003.08.008 }} | ||
* {{cite journal | vauthors = Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG | title = A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors | * {{cite journal | vauthors = Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG | title = A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors | journal = Cell | volume = 116 | issue = 4 | pages = 511–26 | year = 2004 | pmid = 14980219 | doi = 10.1016/S0092-8674(04)00133-3 }} | ||
* {{cite journal | vauthors = Yoon HG, Choi Y, Cole PA, Wong J | title = Reading and function of a histone code involved in targeting corepressor complexes for repression | * {{cite journal | vauthors = Yoon HG, Choi Y, Cole PA, Wong J | title = Reading and function of a histone code involved in targeting corepressor complexes for repression | journal = Mol. Cell. Biol. | volume = 25 | issue = 1 | pages = 324–35 | year = 2005 | pmid = 15601853 | pmc = 538779 | doi = 10.1128/MCB.25.1.324-335.2005 }} | ||
* {{cite journal | vauthors = Gerlitz G, Darhin E, Giorgio G, Franco B, Reiner O | title = Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization | * {{cite journal | vauthors = Gerlitz G, Darhin E, Giorgio G, Franco B, Reiner O | title = Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization | journal = Cell Cycle | volume = 4 | issue = 11 | pages = 1632–40 | year = 2005 | pmid = 16258276 | doi = 10.4161/cc.4.11.2151 }} | ||
{{refend}} | {{refend}} | ||
{{gene-X-stub}} | {{gene-X-stub}} | ||
Latest revision as of 22:52, 5 September 2018
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
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Transducin (beta)-like 1X-linked, also known as TBL1X, is a protein which in humans is encoded by the TBL1X gene.[1]
Function
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. This gene is highly similar to the Y chromosome TBL1Y gene.[1]
Interactions
TBL1X has been shown to interact with:
References
- ↑ 1.0 1.1 "Entrez Gene: TBL1X transducin (beta)-like 1X-linked".
- ↑ 2.0 2.1 2.2 Zhang J, Kalkum M, Chait BT, Roeder RG (March 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Mol. Cell. 9 (3): 611–23. doi:10.1016/s1097-2765(02)00468-9. PMID 11931768.
- ↑ 3.0 3.1 3.2 Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R (May 2000). "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness". Genes Dev. 14 (9): 1048–57. doi:10.1101/gad.14.9.1048 (inactive 2018-09-05). PMC 316569. PMID 10809664.
- ↑ 4.0 4.1 Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J (March 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047. PMID 12628926.
- ↑ 5.0 5.1 Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J (August 2000). "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3". EMBO J. 19 (16): 4342–50. doi:10.1093/emboj/19.16.4342. PMC 302030. PMID 10944117.
- ↑ Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA (December 2002). "Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex". Genes Dev. 16 (24): 3130–5. doi:10.1101/gad.1037502. PMC 187500. PMID 12502735.
Further reading
- Bassi MT, Ramesar RS, Caciotti B, Winship IM, De Grandi A, Riboni M, Townes PL, Beighton P, Ballabio A, Borsani G (1999). "X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats". Am. J. Hum. Genet. 64 (6): 1604–16. doi:10.1086/302408. PMC 1377903. PMID 10330347.
- Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R (2000). "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness". Genes Dev. 14 (9): 1048–57. doi:10.1101/gad.14.9.1048 (inactive 2018-09-05). PMC 316569. PMID 10809664.
- Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J (2000). "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3". EMBO J. 19 (16): 4342–50. doi:10.1093/emboj/19.16.4342. PMC 302030. PMID 10944117.
- Matsuzawa SI, Reed JC (2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Mol. Cell. 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. PMID 11389839.
- Zhang J, Kalkum M, Chait BT, Roeder RG (2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Mol. Cell. 9 (3): 611–23. doi:10.1016/S1097-2765(02)00468-9. PMID 11931768.
- Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J (2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047. PMID 12628926.
- Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J (2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Mol. Cell. 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
- Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG (2004). "A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors". Cell. 116 (4): 511–26. doi:10.1016/S0092-8674(04)00133-3. PMID 14980219.
- Yoon HG, Choi Y, Cole PA, Wong J (2005). "Reading and function of a histone code involved in targeting corepressor complexes for repression". Mol. Cell. Biol. 25 (1): 324–35. doi:10.1128/MCB.25.1.324-335.2005. PMC 538779. PMID 15601853.
- Gerlitz G, Darhin E, Giorgio G, Franco B, Reiner O (2005). "Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization". Cell Cycle. 4 (11): 1632–40. doi:10.4161/cc.4.11.2151. PMID 16258276.
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