Rhabdomyosarcoma classification: Difference between revisions
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==Classification== | ==Classification== | ||
===Histologic classification of rhabdomyosarcoma=== | |||
*The international classification of rhabdomyosarcoma (RMS) was created by the Intergroup Rhabdomyosarcoma Study group (IRSG) therapeutic trials (IRS-I to IV).<ref name="pmid9724344">{{cite journal| author=Qualman SJ, Coffin CM, Newton WA, Hojo H, Triche TJ, Parham DM et al.| title=Intergroup Rhabdomyosarcoma Study: update for pathologists. | journal=Pediatr Dev Pathol | year= 1998 | volume= 1 | issue= 6 | pages= 550-61 | pmid=9724344 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9724344 }} </ref><ref name="pmid12110339">{{cite journal| author=Hicks J, Flaitz C| title=Rhabdomyosarcoma of the head and neck in children. | journal=Oral Oncol | year= 2002 | volume= 38 | issue= 5 | pages= 450-9 | pmid=12110339 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12110339 }} </ref> | |||
*The four main subgroups are: | |||
**Embryonal RMS | |||
**Botryoid and spindle cell (leiomyomatous) RMS | |||
**Sclerosing and spindle cell RMS with MyoD1 mutation | |||
**Alveolar RMS | |||
This system attempts to combine elements of the previous systems and correlate these with prognosis based on tumor type. Rhabdomyosarcomas are classified into five subtypes: | |||
*Alveolar rhabdomyosarcoma | *Alveolar rhabdomyosarcoma | ||
**Usually affects young adults | **Usually affects young adults | ||
Revision as of 16:17, 11 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
Rhabdomyosarcoma may be classified according to the "International classification of rhabdomyosarcoma" into five subtypes: Alveolar rhabdomyosarcoma, embryonal rhabdomyosarcoma, botryoid rhabdomyosarcoma, spindle cell rhabdomyosarcoma, and anaplastic rhabdomyosarcoma.
Classification
Histologic classification of rhabdomyosarcoma
- The international classification of rhabdomyosarcoma (RMS) was created by the Intergroup Rhabdomyosarcoma Study group (IRSG) therapeutic trials (IRS-I to IV).[1][2]
- The four main subgroups are:
- Embryonal RMS
- Botryoid and spindle cell (leiomyomatous) RMS
- Sclerosing and spindle cell RMS with MyoD1 mutation
- Alveolar RMS
This system attempts to combine elements of the previous systems and correlate these with prognosis based on tumor type. Rhabdomyosarcomas are classified into five subtypes:
- Alveolar rhabdomyosarcoma
- Usually affects young adults
- Early metastasis is common
- Embryonal rhabdomyosarcoma
- Usually affects children <10 years of age
- Typically locally invasive
- Botryoid rhabdomyosarcoma
- Spindle cell rhabdomyosarcoma
- Anaplastic rhabdomyosarcoma
Several additional subtypes of rhabdomyosarcoma exist that do not fit into the International Classification scheme:
- Pleomorphic rhabdomyosarcoma: Usually occurs in adults rather than children.
- Sclerosing rhabdomyosarcoma: It is a rare rhabdomyosarcoma subtype.
References
- ↑ Qualman SJ, Coffin CM, Newton WA, Hojo H, Triche TJ, Parham DM; et al. (1998). "Intergroup Rhabdomyosarcoma Study: update for pathologists". Pediatr Dev Pathol. 1 (6): 550–61. PMID 9724344.
- ↑ Hicks J, Flaitz C (2002). "Rhabdomyosarcoma of the head and neck in children". Oral Oncol. 38 (5): 450–9. PMID 12110339.