Rhabdomyosarcoma history and symptoms: Difference between revisions
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Symptoms of rhabdomyosarcoma can vary greatly depending on the size, location and spread of the tumor. Symptoms of parameningeal rhabdomyosarcoma are headache and fascial assymmetry. Symptoms of rhabdomyosarcoma of orbit are proptosis, swollon eyelid, and vision problems. Symptoms of pelvic or abdominal rhabdomyosarcoma are Vomiting, constipation, and abdominal pain. | Symptoms of rhabdomyosarcoma can vary greatly depending on the size, location and spread of the tumor. Symptoms of parameningeal rhabdomyosarcoma are headache and fascial assymmetry. Symptoms of rhabdomyosarcoma of orbit are proptosis, swollon eyelid, and vision problems. Symptoms of pelvic or abdominal rhabdomyosarcoma are Vomiting, constipation, and abdominal pain. | ||
==History and Symptoms== | ==History and Symptoms== | ||
*Symptoms of rhabdomyosarcoma can vary greatly depending on the size, location, patient's age and tumor metastases | *Symptoms of rhabdomyosarcoma can vary greatly depending on the size, location, patient's age and tumor metastases.<ref name="pmid24966711">{{cite journal| author=Egas-Bejar D, Huh WW| title=Rhabdomyosarcoma in adolescent and young adult patients: current perspectives. | journal=Adolesc Health Med Ther | year= 2014 | volume= 5 | issue= | pages= 115-25 | pmid=24966711 | doi=10.2147/AHMT.S44582 | pmc=4069040 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24966711 }}</ref> | ||
*Patients with rhabdomyosarcoma have negative previous history of trauma. | |||
* General symptoms of rhabdomyosarcoma are: | * General symptoms of rhabdomyosarcoma are: | ||
** Palpable mass | ** Palpable mass | ||
| Line 11: | Line 12: | ||
** Erythmatous skin | ** Erythmatous skin | ||
** Fever may be present | ** Fever may be present | ||
** | ** Nasal discharge | ||
* Most symptoms are related to prevalent sites such as: | ** headache | ||
** Head and neck symptoms | ** Vomiting | ||
** Genitourinary tract symptoms | ** Change in hearing, vision, speech, or swallowing | ||
** | * Most symptoms are related to prevalent sites of involvement such as:<ref name="pmid15728225">{{cite journal| author=Stevens MC, Rey A, Bouvet N, Ellershaw C, Flamant F, Habrand JL et al.| title=Treatment of nonmetastatic rhabdomyosarcoma in childhood and adolescence: third study of the International Society of Paediatric Oncology--SIOP Malignant Mesenchymal Tumor 89. | journal=J Clin Oncol | year= 2005 | volume= 23 | issue= 12 | pages= 2618-28 | pmid=15728225 | doi=10.1200/JCO.2005.08.130 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15728225 }}</ref> | ||
** Head and neck mass symptoms | |||
** Genitourinary tract mass symptoms | |||
** Extremity mass symptoms | |||
* Symptoms related to metastases lesions are: | * Symptoms related to metastases lesions are: | ||
** Bone pain | ** Bone pain | ||
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** Abnormal lab test ( anemia, thrombocytopenia, and neutropenia) | ** Abnormal lab test ( anemia, thrombocytopenia, and neutropenia) | ||
** Disseminated rhabdomyoblasts in the bone marrow present with leukemia symptoms | ** Disseminated rhabdomyoblasts in the bone marrow present with leukemia symptoms | ||
{| class="wikitable" | |||
|+symptoms based on origin<ref name="pmid12110339">{{cite journal| author=Hicks J, Flaitz C| title=Rhabdomyosarcoma of the head and neck in children. | journal=Oral Oncol | year= 2002 | volume= 38 | issue= 5 | pages= 450-9 | pmid=12110339 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12110339 }}</ref> | |||
!Origin | |||
!Presentation | |||
|- | |||
|Orbit<ref name="pmid235770292">{{cite journal| author=Rao AA, Naheedy JH, Chen JY, Robbins SL, Ramkumar HL| title=A clinical update and radiologic review of pediatric orbital and ocular tumors. | journal=J Oncol | year= 2013 | volume= 2013 | issue= | pages= 975908 | pmid=23577029 | doi=10.1155/2013/975908 | pmc=3610355 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23577029 }}</ref> | |||
|Proptosis/ dysconjugate gaze/ ophtalmoplasia | |||
|- | |||
|Parameningeal lesions<ref name="pmid23719406">{{cite journal| author=Rahman HA, Sedky M, Mohsen I, Taha H, Loaye I, Zaghloul MS et al.| title=Outcome of pediatric parameningeal rhabdomyosarcoma. The Children Cancer Hospital, Egypt, experience. | journal=J Egypt Natl Canc Inst | year= 2013 | volume= 25 | issue= 2 | pages= 79-86 | pmid=23719406 | doi=10.1016/j.jnci.2013.01.002 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23719406 }}</ref> | |||
|Upper respiratory symptoms such as sinus or nasal obstruction with or without a mucopurulent or bloody discharge | |||
|- | |||
|Bladder | |||
|Hematuria, urinary obstruction | |||
|- | |||
|Prostate | |||
|Urinary frequency, constipation due to tumoral pressure | |||
|- | |||
|Paratesticular lesions | |||
|Scrotal or inguinal enlargement, usually painful mass | |||
|- | |||
|Uterus or cervix | |||
|Menorrhagia or metrorrhagia | |||
|- | |||
|Vagina | |||
|Mucosanguineous discharge in very young girls, protrusion of polypoid mass from vagina | |||
|- | |||
|Extrimities | |||
|Painful or painless mass with or without erythematous skin | |||
|} | |||
==References== | ==References== | ||
Revision as of 19:26, 1 February 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
Symptoms of rhabdomyosarcoma can vary greatly depending on the size, location and spread of the tumor. Symptoms of parameningeal rhabdomyosarcoma are headache and fascial assymmetry. Symptoms of rhabdomyosarcoma of orbit are proptosis, swollon eyelid, and vision problems. Symptoms of pelvic or abdominal rhabdomyosarcoma are Vomiting, constipation, and abdominal pain.
History and Symptoms
- Symptoms of rhabdomyosarcoma can vary greatly depending on the size, location, patient's age and tumor metastases.[1]
- Patients with rhabdomyosarcoma have negative previous history of trauma.
- General symptoms of rhabdomyosarcoma are:
- Palpable mass
- Pain may be present
- Erythmatous skin
- Fever may be present
- Nasal discharge
- headache
- Vomiting
- Change in hearing, vision, speech, or swallowing
- Most symptoms are related to prevalent sites of involvement such as:[2]
- Head and neck mass symptoms
- Genitourinary tract mass symptoms
- Extremity mass symptoms
- Symptoms related to metastases lesions are:
- Bone pain
- Respiratory difficulties
- Abnormal lab test ( anemia, thrombocytopenia, and neutropenia)
- Disseminated rhabdomyoblasts in the bone marrow present with leukemia symptoms
| Origin | Presentation |
|---|---|
| Orbit[4] | Proptosis/ dysconjugate gaze/ ophtalmoplasia |
| Parameningeal lesions[5] | Upper respiratory symptoms such as sinus or nasal obstruction with or without a mucopurulent or bloody discharge |
| Bladder | Hematuria, urinary obstruction |
| Prostate | Urinary frequency, constipation due to tumoral pressure |
| Paratesticular lesions | Scrotal or inguinal enlargement, usually painful mass |
| Uterus or cervix | Menorrhagia or metrorrhagia |
| Vagina | Mucosanguineous discharge in very young girls, protrusion of polypoid mass from vagina |
| Extrimities | Painful or painless mass with or without erythematous skin |
References
- ↑ Egas-Bejar D, Huh WW (2014). "Rhabdomyosarcoma in adolescent and young adult patients: current perspectives". Adolesc Health Med Ther. 5: 115–25. doi:10.2147/AHMT.S44582. PMC 4069040. PMID 24966711.
- ↑ Stevens MC, Rey A, Bouvet N, Ellershaw C, Flamant F, Habrand JL; et al. (2005). "Treatment of nonmetastatic rhabdomyosarcoma in childhood and adolescence: third study of the International Society of Paediatric Oncology--SIOP Malignant Mesenchymal Tumor 89". J Clin Oncol. 23 (12): 2618–28. doi:10.1200/JCO.2005.08.130. PMID 15728225.
- ↑ Hicks J, Flaitz C (2002). "Rhabdomyosarcoma of the head and neck in children". Oral Oncol. 38 (5): 450–9. PMID 12110339.
- ↑ Rao AA, Naheedy JH, Chen JY, Robbins SL, Ramkumar HL (2013). "A clinical update and radiologic review of pediatric orbital and ocular tumors". J Oncol. 2013: 975908. doi:10.1155/2013/975908. PMC 3610355. PMID 23577029.
- ↑ Rahman HA, Sedky M, Mohsen I, Taha H, Loaye I, Zaghloul MS; et al. (2013). "Outcome of pediatric parameningeal rhabdomyosarcoma. The Children Cancer Hospital, Egypt, experience". J Egypt Natl Canc Inst. 25 (2): 79–86. doi:10.1016/j.jnci.2013.01.002. PMID 23719406.